FASLG (Fas ligand (TNF superfamily, member 6))

Identity

Other names	APT1LG1
	CD178
	CD95L
	FASL
	TNFSF6
HGNC	FASLG
Location	1q23
Location_base_pair	Starts at 170894808 and ends at 170902635 bp from pter (hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	FASLG   11936
Entrez_Gene	FASLG  356  Fas ligand (TNF superfamily, member 6)
	Cards
GeneCards	FASLG
Ensembl	FASLG [Search_View]   ENSG00000117560 [Gene_View]
Genatlas	FASLG
GeneLynx	FASLG
eGenome	FASLG
euGene	356
	Genomic and cartography
GoldenPath	FASLG  -  1q23   chr1:170894808-170902635 +  1q24.3   [Description]    (hg18-March_2006)
Ensembl	FASLG - 1q24.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	FASLG
	Gene and transcription
Genbank	AF288573 [ ENTREZ ]
Genbank	AK314874 [ ENTREZ ]
Genbank	AY225406 [ ENTREZ ]
Genbank	AY858799 [ ENTREZ ]
Genbank	BC017502 [ ENTREZ ]
RefSeq	NM_000639 [ SRS ]    NM_000639 [ ENTREZ ]
RefSeq	AC_000044 [ SRS ]    AC_000044 [ ENTREZ ]
RefSeq	AC_000133 [ SRS ]    AC_000133 [ ENTREZ ]
RefSeq	NC_000001 [ SRS ]    NC_000001 [ ENTREZ ]
RefSeq	NG_007269 [ SRS ]    NG_007269 [ ENTREZ ]
RefSeq	NT_004487 [ SRS ]    NT_004487 [ ENTREZ ]
RefSeq	NW_001838533 [ SRS ]    NW_001838533 [ ENTREZ ]
RefSeq	NW_926128 [ SRS ]    NW_926128 [ ENTREZ ]
AceView	FASLG AceView - NCBI
Unigene	Hs.2007 [ SRS ]    Hs.2007 [ NCBI ]     HS2007 [ spliceNest ]
Fast-db	17576 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P48023 [ SRS]    P48023 [ EXPASY ]     P48023 [ INTERPRO ]     P48023 [ UNIPROT ]
Prosite	PS00251 TNF_1 [ SRS ]    PS00251 TNF_1 [ Expasy ]
Prosite	PS50049 TNF_2 [ SRS ]    PS50049 TNF_2 [ Expasy ]
Interpro	IPR008064 Fas_ligand [ SRS ]    IPR008064 Fas_ligand [ EBI ]
Interpro	IPR006053 TNF_abc [ SRS ]    IPR006053 TNF_abc [ EBI ]
Interpro	IPR002961 TNF_C [ SRS ]    IPR002961 TNF_C [ EBI ]
Interpro	IPR006052 TNF_family [ SRS ]    IPR006052 TNF_family [ EBI ]
Interpro	IPR008983 Tumour_necrosis_fac-like [ SRS ]    IPR008983 Tumour_necrosis_fac-like [ EBI ]
CluSTr	P48023
Pfam	PF00229 TNF [ SRS ]    PF00229 TNF [ Sanger ]    pfam00229 [ NCBI-CDD ]
Smart	SM00207 TNF [EMBL]
Prodom	PD002012 TNF_subf[INRA-Toulouse]
Prodom	P48023 TNFL6_HUMAN [ Domain structure ]   P48023 TNFL6_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P48023
PDB	1BZI [ SRS ]    1BZI [ PdbSum ],   1BZI [ IMB ]   1BZI [ RSDB ]
HPRD	00610
	Protein Interaction databases
DIP	P48023
IntAct	P48023
	Polymorphism : SNP, mutations, diseases
OMIM	134638;152700    [ map ]
GENECLINICS	134638;152700
SNP	FASLG [dbSNP-NCBI]
SNP	NM_000639 [SNP-NCI]
SNP	FASLG [GeneSNPs - Utah]  FASLG] [HGBASE - SRS]
HAPMAP	FASLG [HAPMAP]
COSMIC	FASLG [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	FASLG
	General knowledge
Family Browser	FASLG [UCSC Family Browser]
SOURCE	NM_000639
SMD	Hs.2007
SAGE	Hs.2007
GO	cytokine activity [Amigo]  cytokine activity
GO	tumor necrosis factor receptor binding [Amigo]  tumor necrosis factor receptor binding
GO	extracellular region [Amigo]  extracellular region
GO	extracellular region [Amigo]  extracellular region
GO	extracellular space [Amigo]  extracellular space
GO	plasma membrane [Amigo]  plasma membrane
GO	integral to plasma membrane [Amigo]  integral to plasma membrane
GO	immune response [Amigo]  immune response
GO	signal transduction [Amigo]  signal transduction
GO	cell-cell signaling [Amigo]  cell-cell signaling
GO	induction of apoptosis by extracellular signals [Amigo]  induction of apoptosis by extracellular signals
GO	activation of pro-apoptotic gene products [Amigo]  activation of pro-apoptotic gene products
GO	positive regulation of I-kappaB kinase/NF-kappaB cascade [Amigo]  positive regulation of I-kappaB kinase/NF-kappaB cascade
BIOCARTA	HIV-I Nef: negative effector of Fas and TNF    [Genes]
BIOCARTA	Role of nicotinic acetylcholine receptors in the regulation of apoptosis    [Genes]
BIOCARTA	AKT Signaling Pathway    [Genes]
BIOCARTA	Antigen Dependent B Cell Activation    [Genes]
BIOCARTA	Bystander B Cell Activation    [Genes]
BIOCARTA	CTL mediated immune response against target cells    [Genes]
BIOCARTA	FAS signaling pathway ( CD95 )    [Genes]
BIOCARTA	Stress Induction of HSP Regulation    [Genes]
BIOCARTA	IL-2 Receptor Beta Chain in T cell Activation    [Genes]
BIOCARTA	Keratinocyte Differentiation    [Genes]
BIOCARTA	Regulation of transcriptional activity by PML    [Genes]
BIOCARTA	PTEN dependent cell cycle arrest and apoptosis    [Genes]
BIOCARTA	HIV Induced T Cell Apoptosis    [Genes]
KEGG	MAPK signaling pathway
KEGG	Cytokine-cytokine receptor interaction
KEGG	Apoptosis
KEGG	Natural killer cell mediated cytotoxicity
KEGG	Type I diabetes mellitus
PubGene	FASLG
TreeFam	FASLG
CTD	356 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	FASLG Related clones (RZPD - Berlin)
	PubMed
PubMed	303 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 13:12:42 2008