FASN (fatty acid synthase)

Identity

Other names	FAS
	MGC14367
	MGC15706
	OA-519
HGNC	FASN
Location	17q25
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	FASN   3594
Entrez_Gene	FASN  2194  fatty acid synthase
	Cards
GeneCards	FASN
Ensembl	FASN [Search_View]   ENSG00000169710 [Gene_View]
Genatlas	FASN
GeneLynx	FASN
eGenome	FASN
euGene	2194
	Genomic and cartography
GoldenPath	FASN  -  17q25   chr17:77629503-77649395 -  17q25.3   [Description]    (hg18-March_2006)
Ensembl	FASN - 17q25.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	FASN
	Gene and transcription
Genbank	AB209988 [ ENTREZ ]
Genbank	AY451392 [ ENTREZ ]
Genbank	BC007267 [ ENTREZ ]
Genbank	BC007305 [ ENTREZ ]
Genbank	BC007909 [ ENTREZ ]
RefSeq	NM_004104 [ SRS ]    NM_004104 [ ENTREZ ]
RefSeq	AC_000060 [ SRS ]    AC_000060 [ ENTREZ ]
RefSeq	AC_000149 [ SRS ]    AC_000149 [ ENTREZ ]
RefSeq	NC_000017 [ SRS ]    NC_000017 [ ENTREZ ]
RefSeq	NT_010663 [ SRS ]    NT_010663 [ ENTREZ ]
RefSeq	NW_001838459 [ SRS ]    NW_001838459 [ ENTREZ ]
RefSeq	NW_926918 [ SRS ]    NW_926918 [ ENTREZ ]
AceView	FASN AceView - NCBI
Unigene	Hs.83190 [ SRS ]    Hs.83190 [ NCBI ]     HS83190 [ spliceNest ]
Fast-db	15792 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P49327 [ SRS]    P49327 [ EXPASY ]     P49327 [ INTERPRO ]     P49327 [ UNIPROT ]
Prosite	PS50075 ACP_DOMAIN [ SRS ]    PS50075 ACP_DOMAIN [ Expasy ]
Prosite	PS00606 B_KETOACYL_SYNTHASE [ SRS ]    PS00606 B_KETOACYL_SYNTHASE [ Expasy ]
Prosite	PS00012 PHOSPHOPANTETHEINE [ SRS ]    PS00012 PHOSPHOPANTETHEINE [ Expasy ]
Interpro	IPR001227 Ac_transferase_reg [ SRS ]    IPR001227 Ac_transferase_reg [ EBI ]
Interpro	IPR009081 ACP_like [ SRS ]    IPR009081 ACP_like [ EBI ]
Interpro	IPR014043 Acyl_transferase [ SRS ]    IPR014043 Acyl_transferase [ EBI ]
Interpro	IPR013149 AlcDHase_Zn-bd [ SRS ]    IPR013149 AlcDHase_Zn-bd [ EBI ]
Interpro	IPR002198 DHase_sc/Rdtase_SDR [ SRS ]    IPR002198 DHase_sc/Rdtase_SDR [ EBI ]
Interpro	IPR000794 Ketoacyl_synth [ SRS ]    IPR000794 Ketoacyl_synth [ EBI ]
Interpro	IPR014031 Ketoacyl_synth_C [ SRS ]    IPR014031 Ketoacyl_synth_C [ EBI ]
Interpro	IPR014030 Ketoacyl_synth_N [ SRS ]    IPR014030 Ketoacyl_synth_N [ EBI ]
Interpro	IPR013217 Methyltransf_12 [ SRS ]    IPR013217 Methyltransf_12 [ EBI ]
Interpro	IPR016040 NAD(P)-bd [ SRS ]    IPR016040 NAD(P)-bd [ EBI ]
Interpro	IPR006163 Phsphopanteth_bd [ SRS ]    IPR006163 Phsphopanteth_bd [ EBI ]
Interpro	IPR006162 Ppantne_S [ SRS ]    IPR006162 Ppantne_S [ EBI ]
Interpro	IPR001031 Thioesterase [ SRS ]    IPR001031 Thioesterase [ EBI ]
Interpro	IPR016038 Thiolase-like_subgr [ SRS ]    IPR016038 Thiolase-like_subgr [ EBI ]
CluSTr	P49327
Pfam	PF00698 Acyl_transf_1 [ SRS ]    PF00698 Acyl_transf_1 [ Sanger ]    pfam00698 [ NCBI-CDD ]
Pfam	PF00106 adh_short [ SRS ]    PF00106 adh_short [ Sanger ]    pfam00106 [ NCBI-CDD ]
Pfam	PF00107 ADH_zinc_N [ SRS ]    PF00107 ADH_zinc_N [ Sanger ]    pfam00107 [ NCBI-CDD ]
Pfam	PF00109 ketoacyl-synt [ SRS ]    PF00109 ketoacyl-synt [ Sanger ]    pfam00109 [ NCBI-CDD ]
Pfam	PF02801 Ketoacyl-synt_C [ SRS ]    PF02801 Ketoacyl-synt_C [ Sanger ]    pfam02801 [ NCBI-CDD ]
Pfam	PF08242 Methyltransf_12 [ SRS ]    PF08242 Methyltransf_12 [ Sanger ]    pfam08242 [ NCBI-CDD ]
Pfam	PF00550 PP-binding [ SRS ]    PF00550 PP-binding [ Sanger ]    pfam00550 [ NCBI-CDD ]
Pfam	PF00975 Thioesterase [ SRS ]    PF00975 Thioesterase [ Sanger ]    pfam00975 [ NCBI-CDD ]
Blocks	P49327
PDB	1XKT [ SRS ]    1XKT [ PdbSum ],   1XKT [ IMB ]   1XKT [ RSDB ]
PDB	2CG5 [ SRS ]    2CG5 [ PdbSum ],   2CG5 [ IMB ]   2CG5 [ RSDB ]
PDB	2JFD [ SRS ]    2JFD [ PdbSum ],   2JFD [ IMB ]   2JFD [ RSDB ]
PDB	2JFK [ SRS ]    2JFK [ PdbSum ],   2JFK [ IMB ]   2JFK [ RSDB ]
PDB	2PX6 [ SRS ]    2PX6 [ PdbSum ],   2PX6 [ IMB ]   2PX6 [ RSDB ]
HPRD	02567
	Protein Interaction databases
DIP	P49327
IntAct	P49327
	Polymorphism : SNP, mutations, diseases
OMIM	600212    [ map ]
GENECLINICS	600212
SNP	FASN [dbSNP-NCBI]
SNP	NM_004104 [SNP-NCI]
SNP	FASN [GeneSNPs - Utah]  FASN] [HGBASE - SRS]
HAPMAP	FASN [HAPMAP]
HGMD	FASN
	General knowledge
Family Browser	FASN [UCSC Family Browser]
SOURCE	NM_004104
SMD	Hs.83190
SAGE	Hs.83190
Enzyme	2.3.1.85 [ Enzyme-Expasy ]   2.3.1.85 [ Enzyme-SRS ]   2.3.1.85 [ IntEnz-EBI ]   2.3.1.85 [ BRENDA ]   2.3.1.85 [ KEGG ]   2.3.1.85 [ WIT ]
GO	[acyl-carrier-protein] S-acetyltransferase activity [Amigo]  [acyl-carrier-protein] S-acetyltransferase activity
GO	[acyl-carrier-protein] S-acetyltransferase activity [Amigo]  [acyl-carrier-protein] S-acetyltransferase activity
GO	[acyl-carrier-protein] S-malonyltransferase activity [Amigo]  [acyl-carrier-protein] S-malonyltransferase activity
GO	[acyl-carrier-protein] S-malonyltransferase activity [Amigo]  [acyl-carrier-protein] S-malonyltransferase activity
GO	3-oxoacyl-[acyl-carrier-protein] synthase activity [Amigo]  3-oxoacyl-[acyl-carrier-protein] synthase activity
GO	3-oxoacyl-[acyl-carrier-protein] synthase activity [Amigo]  3-oxoacyl-[acyl-carrier-protein] synthase activity
GO	3-oxoacyl-[acyl-carrier-protein] reductase activity [Amigo]  3-oxoacyl-[acyl-carrier-protein] reductase activity
GO	3-oxoacyl-[acyl-carrier-protein] reductase activity [Amigo]  3-oxoacyl-[acyl-carrier-protein] reductase activity
GO	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity [Amigo]  3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
GO	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity [Amigo]  enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
GO	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity [Amigo]  enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
GO	oleoyl-[acyl-carrier-protein] hydrolase activity [Amigo]  oleoyl-[acyl-carrier-protein] hydrolase activity
GO	oleoyl-[acyl-carrier-protein] hydrolase activity [Amigo]  oleoyl-[acyl-carrier-protein] hydrolase activity
GO	protein binding [Amigo]  protein binding
GO	cytoplasm [Amigo]  cytoplasm
GO	cytosol [Amigo]  cytosol
GO	fatty acid biosynthetic process [Amigo]  fatty acid biosynthetic process
GO	oxidoreductase activity [Amigo]  oxidoreductase activity
GO	transferase activity [Amigo]  transferase activity
GO	hydrolase activity, acting on ester bonds [Amigo]  hydrolase activity, acting on ester bonds
GO	lyase activity [Amigo]  lyase activity
GO	phosphopantetheine binding [Amigo]  phosphopantetheine binding
GO	melanosome [Amigo]  melanosome
GO	glycogen granule [Amigo]  glycogen granule
GO	cofactor binding [Amigo]  cofactor binding
GO	oxidation reduction [Amigo]  oxidation reduction
KEGG	Fatty acid biosynthesis
KEGG	Insulin signaling pathway
PubGene	FASN
TreeFam	FASN
CTD	2194 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	FASN Related clones (RZPD - Berlin)
	PubMed
PubMed	63 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:10:36 2008