FBXO45 (F-box protein 45)

2007-04-01  

Identity

HGNC
FBXO45
LOCATION
3q29
LOCUSID
200933
ALIAS
Fbx45
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 200933
MIM: 609112
HGNC: 29148
Ensembl: ENSG00000174013

Variants:

dbSNP: 200933
ClinVar: 200933
TCGA: ENSG00000174013
COSMIC: FBXO45

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174013ENST00000311630P0C2W1
ENSG00000174013ENST00000440469C9JLC0

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
195819262009The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73.36
254605092015Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors.28
249929302014Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival.12
160127412005Characterization of estrogen-induced F-box protein FBXO45.10
299972552018PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2.7
248784302014Novel rare variants in F-box protein 45 (FBXO45) in schizophrenia.5
296652502019A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional expression.4
280114902017Low Expression of FBXO45 Is Associated with Gastric Cancer Progression and Poor Prognosis.2
316443092019Association Study Reveals One Susceptibility Locus with Vitiligo in the Chinese Han Population.1

Citation

Dessen P

FBXO45 (F-box protein 45)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46728/fbxo45