FBXO5 (F-box protein 5)

2008-08-01 Affiliation

Identity

HGNC

FBXO5

LOCATION

6q25.2

LOCUSID

26271

ALIAS

EMI1,FBX5,Fbxo31

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 26271
MIM: 606013
HGNC: 13584
Ensembl: ENSG00000112029

Variants:

dbSNP: 26271
ClinVar: 26271
TCGA: ENSG00000112029
COSMIC: FBXO5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000112029	ENST00000229758	Q9UKT4
ENSG00000112029	ENST00000367241	Q9UKT4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Oocyte meiosis	KEGG	ko04114
Oocyte meiosis	KEGG	hsa04114
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Mitotic G1-G1/S phases	REACTOME	R-HSA-453279
G1/S Transition	REACTOME	R-HSA-69206
G1/S-Specific Transcription	REACTOME	R-HSA-69205
E2F mediated regulation of DNA replication	REACTOME	R-HSA-113510
M Phase	REACTOME	R-HSA-68886
Mitotic Metaphase and Anaphase	REACTOME	R-HSA-2555396
Mitotic Metaphase/Anaphase Transition	REACTOME	R-HSA-68881
Regulation of mitotic cell cycle	REACTOME	R-HSA-453276
APC/C-mediated degradation of cell cycle proteins	REACTOME	R-HSA-174143
Regulation of APC/C activators between G1/S and early anaphase	REACTOME	R-HSA-176408
Phosphorylation of Emi1	REACTOME	R-HSA-176417
SCF-beta-TrCP mediated degradation of Emi1	REACTOME	R-HSA-174113

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
11988738	2002	E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1).	132
17234884	2007	The APC/C inhibitor, Emi1, is essential for prevention of rereplication.	94
16921029	2006	Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.	90
15469984	2004	Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1.	87
17485488	2007	Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C.	67
23708605	2013	Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown.	39
17190794	2007	Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1).	34
20641033	2011	Polymorphisms in predicted miRNA binding sites and osteoporosis.	33
19822658	2009	Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosis.	30
17609108	2007	The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis.	27

Citation

Dessen P

FBXO5 (F-box protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50287/fbxo5