FLT1 (fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor))

Identity

Other names	FLT
	VEGFR1
HGNC	FLT1
Location	13q12
Location_base_pair	Starts at 27774389 and ends at 27967265 bp from pter (hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	FLT1   3763
Entrez_Gene	FLT1  2321  fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
	Cards
GeneCards	FLT1
Ensembl	FLT1 [Search_View]   ENSG00000102755 [Gene_View]
Genatlas	FLT1
GeneLynx	FLT1
eGenome	FLT1
euGene	2321
	Genomic and cartography
GoldenPath	FLT1  -  13q12   chr13:27774389-27967265 -  13q12.2   [Description]    (hg18-March_2006)
Ensembl	FLT1 - 13q12.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	FLT1
	Gene and transcription
Genbank	AB209050 [ ENTREZ ]
Genbank	AF063657 [ ENTREZ ]
Genbank	AK292936 [ ENTREZ ]
Genbank	AK309901 [ ENTREZ ]
Genbank	BC029849 [ ENTREZ ]
RefSeq	NM_002019 [ SRS ]    NM_002019 [ ENTREZ ]
RefSeq	AC_000056 [ SRS ]    AC_000056 [ ENTREZ ]
RefSeq	AC_000145 [ SRS ]    AC_000145 [ ENTREZ ]
RefSeq	NC_000013 [ SRS ]    NC_000013 [ ENTREZ ]
RefSeq	NT_024524 [ SRS ]    NT_024524 [ ENTREZ ]
RefSeq	NW_001838071 [ SRS ]    NW_001838071 [ ENTREZ ]
RefSeq	NW_925473 [ SRS ]    NW_925473 [ ENTREZ ]
AceView	FLT1 AceView - NCBI
Unigene	Hs.654360 [ SRS ]    Hs.654360 [ NCBI ]     HS654360 [ spliceNest ]
Fast-db	1993 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P17948 [ SRS]    P17948 [ EXPASY ]     P17948 [ INTERPRO ]     P17948 [ UNIPROT ]
Prosite	PS50835 IG_LIKE [ SRS ]    PS50835 IG_LIKE [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00109 PROTEIN_KINASE_TYR [ SRS ]    PS00109 PROTEIN_KINASE_TYR [ Expasy ]
Prosite	PS00240 RECEPTOR_TYR_KIN_III [ SRS ]    PS00240 RECEPTOR_TYR_KIN_III [ Expasy ]
Interpro	IPR013151 Ig [ SRS ]    IPR013151 Ig [ EBI ]
Interpro	IPR007110 Ig-like [ SRS ]    IPR007110 Ig-like [ EBI ]
Interpro	IPR013783 Ig-like_fold [ SRS ]    IPR013783 Ig-like_fold [ EBI ]
Interpro	IPR013098 Ig_I-set [ SRS ]    IPR013098 Ig_I-set [ EBI ]
Interpro	IPR003599 Ig_sub [ SRS ]    IPR003599 Ig_sub [ EBI ]
Interpro	IPR003598 Ig_sub2 [ SRS ]    IPR003598 Ig_sub2 [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR001824 Recept_tyr_kinase-III_CS [ SRS ]    IPR001824 Recept_tyr_kinase-III_CS [ EBI ]
Interpro	IPR001245 Tyr_pkinase [ SRS ]    IPR001245 Tyr_pkinase [ EBI ]
Interpro	IPR008266 Tyr_pkinase_AS [ SRS ]    IPR008266 Tyr_pkinase_AS [ EBI ]
Interpro	IPR009135 VEGFR1_N [ SRS ]    IPR009135 VEGFR1_N [ EBI ]
Interpro	IPR009134 VEGFR_N [ SRS ]    IPR009134 VEGFR_N [ EBI ]
CluSTr	P17948
Pfam	PF07679 I-set [ SRS ]    PF07679 I-set [ Sanger ]    pfam07679 [ NCBI-CDD ]
Pfam	PF00047 ig [ SRS ]    PF00047 ig [ Sanger ]    pfam00047 [ NCBI-CDD ]
Pfam	PF07714 Pkinase_Tyr [ SRS ]    PF07714 Pkinase_Tyr [ Sanger ]    pfam07714 [ NCBI-CDD ]
Smart	SM00409 IG [EMBL]
Smart	SM00408 IGc2 [EMBL]
Smart	SM00219 TyrKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	P17948 VGFR1_HUMAN [ Domain structure ]   P17948 VGFR1_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P17948
PDB	1FLT [ SRS ]    1FLT [ PdbSum ],   1FLT [ IMB ]   1FLT [ RSDB ]
PDB	1QSV [ SRS ]    1QSV [ PdbSum ],   1QSV [ IMB ]   1QSV [ RSDB ]
PDB	1QSZ [ SRS ]    1QSZ [ PdbSum ],   1QSZ [ IMB ]   1QSZ [ RSDB ]
PDB	1QTY [ SRS ]    1QTY [ PdbSum ],   1QTY [ IMB ]   1QTY [ RSDB ]
PDB	1RV6 [ SRS ]    1RV6 [ PdbSum ],   1RV6 [ IMB ]   1RV6 [ RSDB ]
HPRD	01297
	Protein Interaction databases
DIP	P17948
IntAct	P17948
	Polymorphism : SNP, mutations, diseases
OMIM	165070    [ map ]
GENECLINICS	165070
SNP	FLT1 [dbSNP-NCBI]
SNP	NM_002019 [SNP-NCI]
SNP	FLT1 [GeneSNPs - Utah]  FLT1] [HGBASE - SRS]
HAPMAP	FLT1 [HAPMAP]
COSMIC	FLT1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	FLT1
	General knowledge
Family Browser	FLT1 [UCSC Family Browser]
SOURCE	NM_002019
SMD	Hs.654360
SAGE	Hs.654360
Enzyme	2.7.10.1 [ Enzyme-Expasy ]   2.7.10.1 [ Enzyme-SRS ]   2.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   2.7.10.1 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	patterning of blood vessels [Amigo]  patterning of blood vessels
GO	receptor activity [Amigo]  receptor activity
GO	vascular endothelial growth factor receptor activity [Amigo]  vascular endothelial growth factor receptor activity
GO	ATP binding [Amigo]  ATP binding
GO	extracellular region [Amigo]  extracellular region
GO	extracellular space [Amigo]  extracellular space
GO	plasma membrane [Amigo]  plasma membrane
GO	integral to plasma membrane [Amigo]  integral to plasma membrane
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	multicellular organismal development [Amigo]  multicellular organismal development
GO	female pregnancy [Amigo]  female pregnancy
GO	positive regulation of cell proliferation [Amigo]  positive regulation of cell proliferation
GO	cell migration [Amigo]  cell migration
GO	transferase activity [Amigo]  transferase activity
GO	cell differentiation [Amigo]  cell differentiation
GO	identical protein binding [Amigo]  identical protein binding
GO	vascular endothelial growth factor receptor signaling pathway [Amigo]  vascular endothelial growth factor receptor signaling pathway
KEGG	Cytokine-cytokine receptor interaction
KEGG	Focal adhesion
PubGene	FLT1
TreeFam	FLT1
CTD	2321 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	FLT1 Related clones (RZPD - Berlin)
	PubMed
PubMed	166 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 13:13:22 2008