FSHR (follicle stimulating hormone receptor)

2003-11-01  

Identity

HGNC
LOCATION
2p16.3
LOCUSID
ALIAS
FSHR1,FSHRO,LGR1,ODG1
FUSION GENES

Other Information

Locus ID:

NCBI: 2492
MIM: 136435
HGNC: 3969
Ensembl: ENSG00000170820

Variants:

dbSNP: 2492
ClinVar: 2492
TCGA: ENSG00000170820
COSMIC: FSHR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170820ENST00000304421P23945
ENSG00000170820ENST00000406846A0A1D5RMN4
ENSG00000170820ENST00000419927F8WBM4
ENSG00000170820ENST00000454032C9JDA1

Expression (GTEx)

0
1
2
3
4

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Hormone ligand-binding receptorsREACTOMER-HSA-375281
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164746560thyrotropin alfaChemicalClinicalAnnotationassociatedPKPD21121812
PA165108853Ovarian hyperstimulation syndromeDiseaseClinicalAnnotationassociatedPKPD21121812
PA444618Infertility, FemaleDiseaseClinicalAnnotationassociatedPKPD21121812
PA449693follitropin betaChemicalClinicalAnnotationassociatedPKPD21121812
PA451835urofollitropinChemicalClinicalAnnotationassociatedPKPD21121812

References

Pubmed IDYearTitleCitations
156624152005Structure of human follicle-stimulating hormone in complex with its receptor.132
158891382005Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity.91
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
228026342012Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor.78
180628612007Gene polymorphisms and male infertility--a meta-analysis and literature review.58
168878872006A phosphorylation cluster of five serine and threonine residues in the C-terminus of the follicle-stimulating hormone receptor is important for desensitization but not for beta-arrestin-mediated ERK activation.53
215332192011An evolutionary genomic approach to identify genes involved in human birth timing.47
186978612008Anti-Mullerian hormone, its receptor, FSH receptor, and androgen receptor genes are overexpressed by granulosa cells from stimulated follicles in women with polycystic ovary syndrome.46
209326542010Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.46
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38

Citation

Dessen P

FSHR (follicle stimulating hormone receptor)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/507/fshr