FSHR (follicle stimulating hormone receptor)

2003-11-01 Affiliation

Identity

HGNC

FSHR

LOCATION

2p16.3

LOCUSID

2492

ALIAS

FSHR1,FSHRO,LGR1,ODG1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2492
MIM: 136435
HGNC: 3969
Ensembl: ENSG00000170820

Variants:

dbSNP: 2492
ClinVar: 2492
TCGA: ENSG00000170820
COSMIC: FSHR

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000170820	ENST00000304421	P23945
ENSG00000170820	ENST00000406846	A0A1D5RMN4
ENSG00000170820	ENST00000419927	F8WBM4
ENSG00000170820	ENST00000454032	C9JDA1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Ovarian steroidogenesis	KEGG	hsa04913
Ovarian steroidogenesis	KEGG	ko04913
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Hormone ligand-binding receptors	REACTOME	R-HSA-375281
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA164746560	thyrotropin alfa	Chemical	ClinicalAnnotation	associated	PK	PD	21121812
PA165108853	Ovarian hyperstimulation syndrome	Disease	ClinicalAnnotation	associated	PK	PD	21121812
PA444618	Infertility, Female	Disease	ClinicalAnnotation	associated	PK	PD	21121812
PA449693	follitropin beta	Chemical	ClinicalAnnotation	associated	PK	PD	21121812
PA451835	urofollitropin	Chemical	ClinicalAnnotation	associated	PK	PD	21121812

References

Pubmed ID	Year	Title	Citations
38664537	2024	Prevalence of FSH-R Asn680Ser and Ala307Thr receptor polymorphism and their correlation with ART outcomes among infertile Indian-Asian women-a prospective cohort study.	0
38664537	2024	Prevalence of FSH-R Asn680Ser and Ala307Thr receptor polymorphism and their correlation with ART outcomes among infertile Indian-Asian women-a prospective cohort study.	0
35680725	2023	The Effect of the Allelics of Ser680Asn Polymorphisms of Follicle-Stimulating Hormone Receptor Gene in IVF/ICSI Cycles: a Systematic Review and Meta-analysis.	2
36350975	2023	Association of FSHR and DENND1A polymorphisms with polycystic ovary syndrome: a meta-analysis.	1
36821034	2023	Analyzing the Impact of FSHR Variants on Polycystic Ovary Syndrome-a Case-Control Study in Punjab.	5
37130623	2023	Association between sequence variants in the FSHR gene and reproductive outcomes following IVF in predicted normoresponders.	0
37228156	2023	Exploring the expression and potential function of follicle stimulating hormone receptor in extragonadal cells related to abdominal aortic aneurysm.	0
37287186	2023	Ala307Thr variation modulates FSHR structure and impairs its binding affinity for FSH: Implications in polycystic ovarian syndrome.	0
37653412	2023	Polymorphisms in FSHR modulating susceptibility to polycystic ovary syndrome: an updated meta-analysis.	0
35680725	2023	The Effect of the Allelics of Ser680Asn Polymorphisms of Follicle-Stimulating Hormone Receptor Gene in IVF/ICSI Cycles: a Systematic Review and Meta-analysis.	2
36350975	2023	Association of FSHR and DENND1A polymorphisms with polycystic ovary syndrome: a meta-analysis.	1
36821034	2023	Analyzing the Impact of FSHR Variants on Polycystic Ovary Syndrome-a Case-Control Study in Punjab.	5
37130623	2023	Association between sequence variants in the FSHR gene and reproductive outcomes following IVF in predicted normoresponders.	0
37228156	2023	Exploring the expression and potential function of follicle stimulating hormone receptor in extragonadal cells related to abdominal aortic aneurysm.	0
37287186	2023	Ala307Thr variation modulates FSHR structure and impairs its binding affinity for FSH: Implications in polycystic ovarian syndrome.	0

Citation

Dessen P

FSHR (follicle stimulating hormone receptor)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/507/fshr