FZD3 (frizzled class receptor 3)

2008-05-01 Affiliation

Identity

HGNC

FZD3

LOCATION

8p21.1

LOCUSID

7976

ALIAS

Fz-3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7976
MIM: 606143
HGNC: 4041
Ensembl: ENSG00000104290

Variants:

dbSNP: 7976
ClinVar: 7976
TCGA: ENSG00000104290
COSMIC: FZD3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000104290	ENST00000240093	Q9NPG1
ENSG00000104290	ENST00000523546	E5RGI9
ENSG00000104290	ENST00000537916	Q9NPG1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
mTOR signaling pathway	KEGG	ko04150
Wnt signaling pathway	KEGG	ko04310
Axon guidance	KEGG	ko04360
Melanogenesis	KEGG	ko04916
Basal cell carcinoma	KEGG	ko05217
mTOR signaling pathway	KEGG	hsa04150
Wnt signaling pathway	KEGG	hsa04310
Axon guidance	KEGG	hsa04360
Melanogenesis	KEGG	hsa04916
Pathways in cancer	KEGG	hsa05200
Basal cell carcinoma	KEGG	hsa05217
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Hippo signaling pathway	KEGG	hsa04390
Hippo signaling pathway	KEGG	ko04390
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
MicroRNAs in cancer	KEGG	hsa05206
MicroRNAs in cancer	KEGG	ko05206
Signaling pathways regulating pluripotency of stem cells	KEGG	hsa04550
Signaling pathways regulating pluripotency of stem cells	KEGG	ko04550
Wnt signaling	KEGG	hsa_M00677
Wnt signaling	KEGG	M00677
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class B/2 (Secretin family receptors)	REACTOME	R-HSA-373080
Signaling by Wnt	REACTOME	R-HSA-195721
Beta-catenin independent WNT signaling	REACTOME	R-HSA-3858494
PCP/CE pathway	REACTOME	R-HSA-4086400
Asymmetric localization of PCP proteins	REACTOME	R-HSA-4608870
Ca2+ pathway	REACTOME	R-HSA-4086398
Breast cancer	KEGG	ko05224
Breast cancer	KEGG	hsa05224

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
18583979	2008	Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.	395
18212053	2008	Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism.	43
20219685	2010	Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression.	29
20819778	2010	MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.	21
14642436	2003	The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia.	19
14642436	2003	The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia.	19
19054571	2009	Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence.	18
24991956	2014	Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways.	18
29902450	2018	Circular RNA circ-CBFB promotes proliferation and inhibits apoptosis in chronic lymphocytic leukemia through regulating miR-607/FZD3/Wnt/β-catenin pathway.	17
15274031	2004	Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population.	12

Citation

Dessen P

FZD3 (frizzled class receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50138/fzd3