GAS2 (growth arrest specific 2)

2003-02-01  

Identity

HGNC
GAS2
LOCATION
11p14.3
LOCUSID
2620
ALIAS
GAS-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2620
MIM: 602835
HGNC: 4167
Ensembl: ENSG00000148935

Variants:

dbSNP: 2620
ClinVar: 2620
TCGA: ENSG00000148935
COSMIC: GAS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148935ENST00000278187O43903
ENSG00000148935ENST00000454584O43903
ENSG00000148935ENST00000524701O43903
ENSG00000148935ENST00000528582E9PQ74
ENSG00000148935ENST00000532398E9PRR5
ENSG00000148935ENST00000533363E9PQ37
ENSG00000148935ENST00000534801E9PM28
ENSG00000148935ENST00000630668O43903

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465
Caspase-mediated cleavage of cytoskeletal proteinsREACTOMER-HSA-264870

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
158174862005The calpain system is involved in the constitutive regulation of beta-catenin signaling functions.25
206794912010Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription.24
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.16
244659532014Growth arrest specific 2 is up-regulated in chronic myeloid leukemia cells and required for their growth.13
259259442015Truncated HBx-dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53-mediated apoptosis.11
263583202015GAS2-Calpain2 axis contributes to the growth of leukemic cells.2
270859732016Upregulation of the growth arrest-specific-2 in recurrent colorectal cancers, and its susceptibility to chemotherapy in a model cell system.0
315280962019Growth arrest-specific gene 2 suppresses hepatocarcinogenesis by intervention of cell cycle and p53-dependent apoptosis.0

Citation

Dessen P

GAS2 (growth arrest specific 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40685/gas2