GAS6 (growth arrest specific 6)

2003-02-01 Affiliation

Identity

HGNC

GAS6

LOCATION

13q34

LOCUSID

2621

ALIAS

AXLLG,AXSF

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2621
MIM: 600441
HGNC: 4168
Ensembl: ENSG00000183087

Variants:

dbSNP: 2621
ClinVar: 2621
TCGA: ENSG00000183087
COSMIC: GAS6

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000183087	ENST00000327773	Q14393

Expression (GTEx)

500

1000

1500

2000

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activation	REACTOME	R-HSA-163841
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	REACTOME	R-HSA-159854
Gamma-carboxylation of protein precursors	REACTOME	R-HSA-159740
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	REACTOME	R-HSA-159763
Removal of aminoterminal propeptides from gamma-carboxylated proteins	REACTOME	R-HSA-159782
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Response to elevated platelet cytosolic Ca2+	REACTOME	R-HSA-76005
Platelet degranulation	REACTOME	R-HSA-114608
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733
EGFR tyrosine kinase inhibitor resistance	KEGG	ko01521
EGFR tyrosine kinase inhibitor resistance	KEGG	hsa01521

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA28660	GGCX	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
11175853	2001	Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis.	124
20126470	2010	GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche.	109
18172262	2008	Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme.	107
25187556	2014	Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.	89
21501828	2011	The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry.	83
16362042	2006	Structural basis for Gas6-Axl signalling.	77
15605394	2005	Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor.	70
28167751	2017	AXL-dependent infection of human fetal endothelial cells distinguishes Zika virus from other pathogenic flaviviruses.	67
19965679	2010	Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6.	64
20103767	2010	TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages.	59

Citation

Dessen P

GAS6 (growth arrest specific 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40687/gas6