GAS8 (growth arrest specific 8)

2003-06-01  

Identity

HGNC
GAS8
LOCATION
16q24.3
LOCUSID
2622
ALIAS
CILD33,DRC4,GAS11
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2622
MIM: 605178
HGNC: 4166
Ensembl: ENSG00000141013

Variants:

dbSNP: 2622
ClinVar: 2622
TCGA: ENSG00000141013
COSMIC: GAS8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141013ENST00000268699O95995
ENSG00000141013ENST00000268699A0A384MR00
ENSG00000141013ENST00000536122O95995
ENSG00000141013ENST00000561675H3BUA7
ENSG00000141013ENST00000564392H3BP65
ENSG00000141013ENST00000565062H3BQT7
ENSG00000141013ENST00000566266H3BME0
ENSG00000141013ENST00000620723A0A087WZT7

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'on' stateREACTOMER-HSA-5632684
Activation of SMOREACTOMER-HSA-5635838

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
263875942015Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia and Disrupt the Nexin-Dynein Regulatory Complex.29
274720562016Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease.12
271201272016Mutations in GAS8, a Gene Encoding a Nexin-Dynein Regulatory Complex Subunit, Cause Primary Ciliary Dyskinesia with Axonemal Disorganization.11
293273012018LncRNA GAS8-AS1 inhibits cell proliferation through ATG5-mediated autophagy in papillary thyroid cancer.10
302281802018The long noncoding RNA <i>GAS8-AS1</i> suppresses hepatocarcinogenesis by epigenetically activating the tumor suppressor <i>GAS8</i>.8
199954612009Interaction of influenza virus NS1 protein with growth arrest-specific protein 8.4
310038312019GAS8 and its naturally occurring antisense RNA as biomarkers in multiple sclerosis.0

Citation

Dessen P

GAS8 (growth arrest specific 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40688/gas8