GNA12 (G protein subunit alpha 12)

2003-02-01  

Identity

HGNC
LOCATION
7p22.3
LOCUSID
ALIAS
NNX3,RMP,gep
FUSION GENES

Other Information

Locus ID:

NCBI: 2768
MIM: 604394
HGNC: 4380
Ensembl: ENSG00000146535

Variants:

dbSNP: 2768
ClinVar: 2768
TCGA: ENSG00000146535
COSMIC: GNA12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146535ENST00000275364Q03113
ENSG00000146535ENST00000407653E9PC54
ENSG00000146535ENST00000407904Q03113
ENSG00000146535ENST00000447791C9J2Y7

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Long-term depressionKEGGko04730
Regulation of actin cytoskeletonKEGGko04810
MAPK signaling pathwayKEGGhsa04010
Long-term depressionKEGGhsa04730
Regulation of actin cytoskeletonKEGGhsa04810
Pathways in cancerKEGGhsa05200
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Thrombin signalling through proteinase activated receptors (PARs)REACTOMER-HSA-456926
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA27946F2RGenePathwayassociated20938371
PA27949F2RL3GenePathwayassociated20938371
PA32868P2RY1GenePathwayassociated20938371
PA33384PLCB1GenePathwayassociated20938371
PA33393PLCG2GenePathwayassociated20938371
PA348TBXA2RGenePathwayassociated20938371

References

Pubmed IDYearTitleCitations
193431782009Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.112
192262832009Regulation of RhoGEF proteins by G12/13-coupled receptors.80
125158662003Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF.69
167050362006The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis.63
190088572008P2Y6 receptor-Galpha12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis.62
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
167879202006A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion.61
122975122002Coordinated signaling through both G12/13 and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets.39
187137482008Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q.37
119763332002Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin.32

Citation

Dessen P

GNA12 (G protein subunit alpha 12)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40725/gna12