GNB3 (G protein subunit beta 3)

2006-10-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
CSNB1H
FUSION GENES

Other Information

Locus ID:

NCBI: 2784
MIM: 139130
HGNC: 4400
Ensembl: ENSG00000111664

Variants:

dbSNP: 2784
ClinVar: 2784
TCGA: ENSG00000111664
COSMIC: GNB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111664ENST00000229264P16520
ENSG00000111664ENST00000229264F1T0G5
ENSG00000111664ENST00000435982E9PCP0
ENSG00000111664ENST00000537035F5H0S8
ENSG00000111664ENST00000539127F5GZN8
ENSG00000111664ENST00000541257F5H8J8
ENSG00000111664ENST00000541978F5H100

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Taste transductionKEGGko04742
Taste transductionKEGGhsa04742
Pathways in cancerKEGGhsa05200
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Cholinergic synapseKEGGhsa04725
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Serotonergic synapseKEGGhsa04726
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
Ras signaling pathwayKEGGhsa04014
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Peptide hormone metabolismREACTOMER-HSA-2980736
Incretin synthesis, secretion, and inactivationREACTOMER-HSA-400508
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)REACTOMER-HSA-381771
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Activation of Kainate Receptors upon glutamate bindingREACTOMER-HSA-451326
Presynaptic function of Kainate receptorsREACTOMER-HSA-500657
GABA receptor activationREACTOMER-HSA-977443
GABA B receptor activationREACTOMER-HSA-977444
Activation of GABAB receptorsREACTOMER-HSA-991365
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunitsREACTOMER-HSA-997272
Potassium ChannelsREACTOMER-HSA-1296071
Inwardly rectifying K+ channelsREACTOMER-HSA-1296065
G protein gated Potassium channelsREACTOMER-HSA-1296059
Activation of G protein gated Potassium channelsREACTOMER-HSA-1296041
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Prostacyclin signalling through prostacyclin receptorREACTOMER-HSA-392851
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Signal amplificationREACTOMER-HSA-392518
ADP signalling through P2Y purinoceptor 12REACTOMER-HSA-392170
ADP signalling through P2Y purinoceptor 1REACTOMER-HSA-418592
Thromboxane signalling through TP receptorREACTOMER-HSA-428930
Thrombin signalling through proteinase activated receptors (PARs)REACTOMER-HSA-456926
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Glucagon-type ligand receptorsREACTOMER-HSA-420092
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (z) signalling eventsREACTOMER-HSA-418597
G alpha (q) signalling eventsREACTOMER-HSA-416476
G alpha (12/13) signalling eventsREACTOMER-HSA-416482
G-protein beta:gamma signallingREACTOMER-HSA-397795
G beta:gamma signalling through PI3KgammaREACTOMER-HSA-392451
G beta:gamma signalling through PLC betaREACTOMER-HSA-418217
Opioid SignallingREACTOMER-HSA-111885
G-protein activationREACTOMER-HSA-202040
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Aquaporin-mediated transportREACTOMER-HSA-445717
Vasopressin regulates renal water homeostasis via AquaporinsREACTOMER-HSA-432040
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Adrenaline,noradrenaline inhibits insulin secretionREACTOMER-HSA-400042
Glucagon-like Peptide-1 (GLP1) regulates insulin secretionREACTOMER-HSA-381676
Glucagon signaling in metabolic regulationREACTOMER-HSA-163359
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406954Weight gainDiseaseClinicalAnnotationassociatedPD19193342
PA133950441hmg coa reductase inhibitorsChemicalClinicalAnnotationassociatedPD18551043
PA134971947P2RY12GenePathwayassociated20938371
PA164712535Beta Blocking AgentsChemicalClinicalAnnotationassociated20860462
PA164713347Thiazides, plainChemicalClinicalAnnotationassociatedPD19247266
PA164741137ADCY3GenePathwayassociated20938371
PA166176017hydralazine / isosorbide dinitrateChemicalClinicalAnnotationassociatedPD25306451
PA27946F2RGenePathwayassociated20938371
PA27949F2RL3GenePathwayassociated20938371
PA32868P2RY1GenePathwayassociated20938371
PA33384PLCB1GenePathwayassociated20938371
PA33385PLCB2GenePathwayassociated
PA33386PLCB3GenePathwayassociated
PA33387PLCB4GenePathwayassociated
PA33393PLCG2GenePathwayassociated20938371
PA348TBXA2RGenePathwayassociated20938371
PA443742Cluster HeadacheDiseaseClinicalAnnotationassociatedPD17361120
PA443886Diabetes MellitusDiseaseClinicalAnnotationassociatedPD19247266
PA444370Heart FailureDiseaseClinicalAnnotationassociatedPD25306451
PA444516HypercholesterolemiaDiseaseClinicalAnnotationassociatedPD18551043
PA444606Erectile DysfunctionDiseaseClinicalAnnotationassociatedPD12576843
PA444797Liver CirrhosisDiseaseClinicalAnnotationassociatedPD12844135, 20833658
PA445019Myocardial InfarctionDiseaseClinicalAnnotationassociatedPD18551043
PA445043Opioid-Related DisordersDiseaseClinicalAnnotationassociatedPD19303909
PA445131ObesityDiseaseClinicalAnnotationassociatedPD12893983
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD19193342
PA447288Essential hypertensionDiseaseClinicalAnnotationassociatedPD20235788
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD20826553, 23733030, 30324302
PA448499atenololChemicalClinicalAnnotationassociatedPD20235788
PA448682bumetanideChemicalClinicalAnnotationassociatedPD20877298
PA449051clonidineChemicalClinicalAnnotationassociatedPD12844135, 20833658
PA449719furosemideChemicalClinicalAnnotationassociatedPD20877298
PA450401methadoneChemicalClinicalAnnotationassociatedPD19303909
PA450657nortriptylineChemicalClinicalAnnotationassociatedPD20826553
PA450688olanzapineChemicalClinicalAnnotationassociatedPD19193342
PA451333sertralineChemicalClinicalAnnotationassociatedPD30324302
PA451344sibutramineChemicalClinicalAnnotationassociatedPD12893983
PA451346sildenafilChemicalClinicalAnnotationassociatedPD12576843
PA451566sumatriptanChemicalClinicalAnnotationassociatedPD17361120
PA451605telmisartanChemicalClinicalAnnotationassociatedPD
PA451733torasemideChemicalClinicalAnnotationassociatedPD20877298
PA452229antidepressantsChemicalClinicalAnnotationassociatedPD23733030

References

Pubmed IDYearTitleCitations
203517142011Poor replication of candidate genes for major depressive disorder using genome-wide association data.92
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
150577362004G-protein beta 3 subunit 825 CC genotype is associated with unexplained (functional) dyspepsia.55
150577362004G-protein beta 3 subunit 825 CC genotype is associated with unexplained (functional) dyspepsia.55
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
164642202006A study of candidate genotypes associated with dyspepsia in a U.S. community.37
206738682010A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).36
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
167626212006Is there an association between GNbeta3-C825T genotype and lower functional gastrointestinal disorders?31
185117402008Candidate genes and sensory functions in health and irritable bowel syndrome.31

Citation

Dessen P

GNB3 (G protein subunit beta 3)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43286/gnb3