GRK4 (G protein-coupled receptor kinase 4)

Identity

Other names	GPRK2L
	GPRK4
	GRK4a
	IT11
Hugo	GRK4
Location	4p16.3
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
Hugo	GRK4
GDB	GRK4
Entrez_Gene	GRK4  2868  G protein-coupled receptor kinase 4
	Cards
GeneCards	GRK4
Ensembl	GRK4 [Search_View]   ENSG00000125388 [Gene_View]
Genatlas	GRK4
GeneLynx	GRK4
eGenome	GRK4
euGene	2868
	Genomic and cartography
GoldenPath	GRK4  -  4p16.3   chr4:2935141-3012272 +  4p16.3   [Description]    (hg18-March_2006)
Ensembl	GRK4 - 4p16.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	GRK4
	Gene and transcription
Genbank	AK223581 [ ENTREZ ]
Genbank	AK292390 [ ENTREZ ]
Genbank	BC027597 [ ENTREZ ]
Genbank	BC117320 [ ENTREZ ]
Genbank	BI465220 [ ENTREZ ]
RefSeq	NM_001004056 [ SRS ]    NM_001004056 [ ENTREZ ]
RefSeq	NM_001004057 [ SRS ]    NM_001004057 [ ENTREZ ]
RefSeq	NM_182982 [ SRS ]    NM_182982 [ ENTREZ ]
RefSeq	AC_000047 [ SRS ]    AC_000047 [ ENTREZ ]
RefSeq	NC_000004 [ SRS ]    NC_000004 [ ENTREZ ]
RefSeq	NT_006081 [ SRS ]    NT_006081 [ ENTREZ ]
RefSeq	NW_921918 [ SRS ]    NW_921918 [ ENTREZ ]
AceView	GRK4 AceView - NCBI
Unigene	Hs.32959 [ SRS ]    Hs.32959 [ NCBI ]     HS32959 [ spliceNest ]
Fast-db	1451 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P32298 [ SRS]    P32298 [ EXPASY ]     P32298 [ INTERPRO ]
Prosite	PS51285 AGC_KINASE_CTER [ SRS ]    PS51285 AGC_KINASE_CTER [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Prosite	PS50132 RGS [ SRS ]    PS50132 RGS [ Expasy ]
Interpro	IPR000239 GPCR_kinase [ SRS ]    IPR000239 GPCR_kinase [ EBI ]
Interpro	IPR000961 Pkinase_C [ SRS ]    IPR000961 Pkinase_C [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR000342 Regulat_G_prot_signal [ SRS ]    IPR000342 Regulat_G_prot_signal [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR002290 Ser_thr_pkinase [ SRS ]    IPR002290 Ser_thr_pkinase [ EBI ]
CluSTr	P32298
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Pfam	PF00615 RGS [ SRS ]    PF00615 RGS [ Sanger ]    pfam00615 [ NCBI-CDD ]
Smart	SM00315 RGS [EMBL]
Smart	SM00133 S_TK_X [EMBL]
Smart	SM00220 S_TKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	P32298 GRK4_HUMAN [ Domain structure ]   P32298 GRK4_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P32298
HPRD	00656
	Protein Interaction databases
DIP	P32298
IntAct	P32298
	Polymorphism : SNP, mutations, diseases
OMIM	137026    [ map ]
GENECLINICS	137026
SNP	GRK4 [dbSNP-NCBI]
SNP	NM_001004056 [SNP-NCI]
SNP	NM_001004057 [SNP-NCI]
SNP	NM_182982 [SNP-NCI]
SNP	GRK4 [GeneSNPs - Utah]  GRK4] [HGBASE - SRS]
HAPMAP	GRK4 [HAPMAP]
COSMIC	GRK4 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	GRK4
	General knowledge
Family Browser	GRK4 [UCSC Family Browser]
SOURCE	NM_001004056
SOURCE	NM_001004057
SOURCE	NM_182982
SMD	Hs.32959
SAGE	Hs.32959
Enzyme	2.7.11.16 [ Enzyme-SRS ]   2.7.11.16 [ Brenda-SRS ]   2.7.11.16 [ KEGG ]   2.7.11.16 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	G-protein coupled receptor kinase activity [Amigo]  G-protein coupled receptor kinase activity
GO	signal transducer activity [Amigo]  signal transducer activity
GO	ATP binding [Amigo]  ATP binding
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	signal transduction [Amigo]  signal transduction
GO	regulation of G-protein coupled receptor protein signaling pathway [Amigo]  regulation of G-protein coupled receptor protein signaling pathway
GO	transferase activity [Amigo]  transferase activity
BIOCARTA	Attenuation of GPCR Signaling    [Genes]
PubGene	GRK4
TreeFam	GRK4
CTD	2868 [Comparative Genomics Database]
	Other databases
	Probes
Probe	GRK4 Related clones (RZPD - Berlin)
	PubMed
PubMed	20 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu May 22 20:09:28 2008