GZMB (granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1))

Identity

Other names	CCPI
	CGL-1
	CGL1
	CSP-B
	CSPB
	CTLA1
	CTSGL1
	HLP
	SECT
HGNC	GZMB
Location	14q11.2
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	GZMB   4709
Entrez_Gene	GZMB  3002  granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
	Cards
GeneCards	GZMB
Ensembl	GZMB [Search_View]   ENSG00000100453 [Gene_View]
Genatlas	GZMB
GeneLynx	GZMB
eGenome	GZMB
euGene	3002
	Genomic and cartography
GoldenPath	GZMB  -  14q11.2   chr14:24170002-24173272 -  14q12   [Description]    (hg18-March_2006)
Ensembl	GZMB - 14q12 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	GZMB
	Gene and transcription
Genbank	AY232654 [ ENTREZ ]
Genbank	AY232655 [ ENTREZ ]
Genbank	AY232656 [ ENTREZ ]
Genbank	AY372494 [ ENTREZ ]
Genbank	BC030195 [ ENTREZ ]
RefSeq	NM_004131 [ SRS ]    NM_004131 [ ENTREZ ]
RefSeq	AC_000057 [ SRS ]    AC_000057 [ ENTREZ ]
RefSeq	AC_000146 [ SRS ]    AC_000146 [ ENTREZ ]
RefSeq	NC_000014 [ SRS ]    NC_000014 [ ENTREZ ]
RefSeq	NT_026437 [ SRS ]    NT_026437 [ ENTREZ ]
RefSeq	NW_001838110 [ SRS ]    NW_001838110 [ ENTREZ ]
RefSeq	NW_925539 [ SRS ]    NW_925539 [ ENTREZ ]
AceView	GZMB AceView - NCBI
Unigene	Hs.1051 [ SRS ]    Hs.1051 [ NCBI ]     HS1051 [ spliceNest ]
Fast-db	121 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P10144 [ SRS]    P10144 [ EXPASY ]     P10144 [ INTERPRO ]     P10144 [ UNIPROT ]
Prosite	PS50240 TRYPSIN_DOM [ SRS ]    PS50240 TRYPSIN_DOM [ Expasy ]
Prosite	PS00134 TRYPSIN_HIS [ SRS ]    PS00134 TRYPSIN_HIS [ Expasy ]
Prosite	PS00135 TRYPSIN_SER [ SRS ]    PS00135 TRYPSIN_SER [ Expasy ]
Interpro	IPR001254 Peptidase_S1_S6 [ SRS ]    IPR001254 Peptidase_S1_S6 [ EBI ]
Interpro	IPR001314 Peptidase_S1A [ SRS ]    IPR001314 Peptidase_S1A [ EBI ]
CluSTr	P10144
Pfam	PF00089 Trypsin [ SRS ]    PF00089 Trypsin [ Sanger ]    pfam00089 [ NCBI-CDD ]
Smart	SM00020 Tryp_SPc [EMBL]
Blocks	P10144
PDB	1FQ3 [ SRS ]    1FQ3 [ PdbSum ],   1FQ3 [ IMB ]   1FQ3 [ RSDB ]
PDB	1IAU [ SRS ]    1IAU [ PdbSum ],   1IAU [ IMB ]   1IAU [ RSDB ]
HPRD	00476
	Protein Interaction databases
DIP	P10144
IntAct	P10144
	Polymorphism : SNP, mutations, diseases
OMIM	123910    [ map ]
GENECLINICS	123910
SNP	GZMB [dbSNP-NCBI]
SNP	NM_004131 [SNP-NCI]
SNP	GZMB [GeneSNPs - Utah]  GZMB] [HGBASE - SRS]
HAPMAP	GZMB [HAPMAP]
HGMD	GZMB
	General knowledge
Family Browser	GZMB [UCSC Family Browser]
SOURCE	NM_004131
SMD	Hs.1051
SAGE	Hs.1051
Enzyme	3.4.21.79 [ Enzyme-Expasy ]   3.4.21.79 [ Enzyme-SRS ]   3.4.21.79 [ IntEnz-EBI ]   3.4.21.79 [ BRENDA ]   3.4.21.79 [ KEGG ]   3.4.21.79 [ WIT ]
GO	immunological synapse [Amigo]  immunological synapse
GO	catalytic activity [Amigo]  catalytic activity
GO	serine-type endopeptidase activity [Amigo]  serine-type endopeptidase activity
GO	granzyme B activity [Amigo]  granzyme B activity
GO	granzyme B activity [Amigo]  granzyme B activity
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	cytosol [Amigo]  cytosol
GO	proteolysis [Amigo]  proteolysis
GO	apoptosis [Amigo]  apoptosis
GO	cleavage of lamin [Amigo]  cleavage of lamin
GO	peptidase activity [Amigo]  peptidase activity
GO	cytolysis [Amigo]  cytolysis
BIOCARTA	Apoptotic DNA fragmentation and tissue homeostasis    [Genes]
BIOCARTA	Caspase Cascade in Apoptosis    [Genes]
BIOCARTA	CTL mediated immune response against target cells    [Genes]
BIOCARTA	D4-GDI Signaling Pathway    [Genes]
BIOCARTA	Granzyme A mediated Apoptosis Pathway    [Genes]
KEGG	Natural killer cell mediated cytotoxicity
KEGG	Type I diabetes mellitus
PubGene	GZMB
TreeFam	GZMB
CTD	3002 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	GZMB Related clones (RZPD - Berlin)
	PubMed
PubMed	122 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:13:39 2008