HDAC10 (histone deacetylase 10)

2007-02-01  

Identity

HGNC
LOCATION
22q13.33
LOCUSID
ALIAS
HD10
FUSION GENES

Other Information

Locus ID:

NCBI: 83933
MIM: 608544
HGNC: 18128
Ensembl: ENSG00000100429

Variants:

dbSNP: 83933
ClinVar: 83933
TCGA: ENSG00000100429
COSMIC: HDAC10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100429ENST00000216271Q969S8
ENSG00000100429ENST00000349505Q969S8
ENSG00000100429ENST00000415993Q08AP5
ENSG00000100429ENST00000429374Q08AP5
ENSG00000100429ENST00000448072C9J8B8
ENSG00000100429ENST00000454936Q969S8
ENSG00000100429ENST00000626012Q08AP5

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by NOTCH1 in CancerREACTOMER-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in CancerREACTOMER-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain MutantsREACTOMER-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerREACTOMER-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsREACTOMER-HSA-2894862
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
376577522023Knockdown of HDAC10 inhibits POLE2-mediated DNA damage repair in NSCLC cells by increasing SP1 acetylation levels.1
376577522023Knockdown of HDAC10 inhibits POLE2-mediated DNA damage repair in NSCLC cells by increasing SP1 acetylation levels.1
351435202022Short communication: TNF-α and IGF-1 regulates epigenetic mechanisms of HDAC2 and HDAC10.1
351435202022Short communication: TNF-α and IGF-1 regulates epigenetic mechanisms of HDAC2 and HDAC10.1
334813342021Histone deacetylase 10 exerts antitumor effects on cervical cancer via a novel microRNA-223/TXNIP/Wnt/β-catenin pathway.3
334933812021Oncogenic miRNA-1908 targets HDAC10 and promotes the aggressive phenotype of cervical cancer cell.6
334813342021Histone deacetylase 10 exerts antitumor effects on cervical cancer via a novel microRNA-223/TXNIP/Wnt/β-catenin pathway.3
334933812021Oncogenic miRNA-1908 targets HDAC10 and promotes the aggressive phenotype of cervical cancer cell.6
318621402020Histone deacetylase 10 knockout activates chaperone-mediated autophagy and accelerates the decomposition of its substrate.12
318621402020Histone deacetylase 10 knockout activates chaperone-mediated autophagy and accelerates the decomposition of its substrate.12
302040522019Homology modeling of human histone deacetylase 10 and design of potential selective inhibitors.6
305158172019HDAC10 upregulation contributes to interleukin 1β-mediated inflammatory activation of synovium-derived mesenchymal stem cells in temporomandibular joint.19
318880842019Characterization of the Role of Host Cellular Factor Histone Deacetylase 10 during HIV-1 Replication.5
302040522019Homology modeling of human histone deacetylase 10 and design of potential selective inhibitors.6
305158172019HDAC10 upregulation contributes to interleukin 1β-mediated inflammatory activation of synovium-derived mesenchymal stem cells in temporomandibular joint.19

Citation

Dessen P

HDAC10 (histone deacetylase 10)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43706/hdac10