HERC2 (hect domain and RLD 2)

Identity

Other names	D15F37S1
	DKFZp547P028
	KIAA0393
	SHEP1
	jdf2
	p528
Hugo	HERC2
Location	15q13
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
Hugo	HERC2
GDB	HERC2
Entrez_Gene	HERC2  8924  hect domain and RLD 2
	Cards
GeneCards	HERC2
Ensembl	HERC2 [Search_View]   ENSG00000128731 [Gene_View]
Genatlas	HERC2
GeneLynx	HERC2
eGenome	HERC2
euGene	8924
	Genomic and cartography
GoldenPath	HERC2  -  15q13   chr15:26029783-26240890 -  15q13.1   [Description]    (hg18-March_2006)
Ensembl	HERC2 - 15q13.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	HERC2
	Gene and transcription
Genbank	AF071172 [ ENTREZ ]
Genbank	AI820017 [ ENTREZ ]
Genbank	AK122977 [ ENTREZ ]
Genbank	AK125229 [ ENTREZ ]
Genbank	AL834183 [ ENTREZ ]
RefSeq	NM_004667 [ SRS ]    NM_004667 [ ENTREZ ]
RefSeq	AC_000058 [ SRS ]    AC_000058 [ ENTREZ ]
RefSeq	NC_000015 [ SRS ]    NC_000015 [ ENTREZ ]
RefSeq	NT_010280 [ SRS ]    NT_010280 [ ENTREZ ]
RefSeq	NW_925783 [ SRS ]    NW_925783 [ ENTREZ ]
AceView	HERC2 AceView - NCBI
Unigene	Hs.610412 [ SRS ]    Hs.610412 [ NCBI ]     HS610412 [ spliceNest ]
Fast-db	512 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O95714 [ SRS]    O95714 [ EXPASY ]     O95714 [ INTERPRO ]
Prosite	PS00191 CYTOCHROME_B5_1 [ SRS ]    PS00191 CYTOCHROME_B5_1 [ Expasy ]
Prosite	PS50255 CYTOCHROME_B5_2 [ SRS ]    PS50255 CYTOCHROME_B5_2 [ Expasy ]
Prosite	PS51284 DOC [ SRS ]    PS51284 DOC [ Expasy ]
Prosite	PS50237 HECT [ SRS ]    PS50237 HECT [ Expasy ]
Prosite	PS00625 RCC1_1 [ SRS ]    PS00625 RCC1_1 [ Expasy ]
Prosite	PS00626 RCC1_2 [ SRS ]    PS00626 RCC1_2 [ Expasy ]
Prosite	PS50012 RCC1_3 [ SRS ]    PS50012 RCC1_3 [ Expasy ]
Prosite	PS00678 WD_REPEATS_1 [ SRS ]    PS00678 WD_REPEATS_1 [ Expasy ]
Prosite	PS50082 WD_REPEATS_2 [ SRS ]    PS50082 WD_REPEATS_2 [ Expasy ]
Prosite	PS50294 WD_REPEATS_REGION [ SRS ]    PS50294 WD_REPEATS_REGION [ Expasy ]
Prosite	PS01357 ZF_ZZ_1 [ SRS ]    PS01357 ZF_ZZ_1 [ Expasy ]
Prosite	PS50135 ZF_ZZ_2 [ SRS ]    PS50135 ZF_ZZ_2 [ Expasy ]
Interpro	IPR001199 Cyt_B5 [ SRS ]    IPR001199 Cyt_B5 [ EBI ]
Interpro	IPR000569 HECT [ SRS ]    IPR000569 HECT [ EBI ]
Interpro	IPR010606 MIB_HERC2 [ SRS ]    IPR010606 MIB_HERC2 [ EBI ]
Interpro	IPR000408 Reg_chr_condens [ SRS ]    IPR000408 Reg_chr_condens [ EBI ]
Interpro	IPR009091 Reg_csome_cond/b-lactamase_inh [ SRS ]    IPR009091 Reg_csome_cond/b-lactamase_inh [ EBI ]
Interpro	IPR006624 TECPR [ SRS ]    IPR006624 TECPR [ EBI ]
Interpro	IPR001680 WD40_repeat [ SRS ]    IPR001680 WD40_repeat [ EBI ]
Interpro	IPR000433 Znf_ZZ [ SRS ]    IPR000433 Znf_ZZ [ EBI ]
CluSTr	O95714
Pfam	PF00173 Cyt-b5 [ SRS ]    PF00173 Cyt-b5 [ Sanger ]    pfam00173 [ NCBI-CDD ]
Pfam	PF00632 HECT [ SRS ]    PF00632 HECT [ Sanger ]    pfam00632 [ NCBI-CDD ]
Pfam	PF06701 MIB_HERC2 [ SRS ]    PF06701 MIB_HERC2 [ Sanger ]    pfam06701 [ NCBI-CDD ]
Pfam	PF00415 RCC1 [ SRS ]    PF00415 RCC1 [ Sanger ]    pfam00415 [ NCBI-CDD ]
Pfam	PF00569 ZZ [ SRS ]    PF00569 ZZ [ Sanger ]    pfam00569 [ NCBI-CDD ]
Smart	SM00119 HECTc [EMBL]
Smart	SM00706 TECPR [EMBL]
Smart	SM00291 ZnF_ZZ [EMBL]
Prodom	PD000612 Cyt_B5[INRA-Toulouse]
Prodom	O95714 HERC2_HUMAN [ Domain structure ]   O95714 HERC2_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	O95714
HPRD	06905
	Protein Interaction databases
DIP	O95714
IntAct	O95714
	Polymorphism : SNP, mutations, diseases
OMIM	227220;605837    [ map ]
GENECLINICS	227220;605837
SNP	HERC2 [dbSNP-NCBI]
SNP	NM_004667 [SNP-NCI]
SNP	HERC2 [GeneSNPs - Utah]  HERC2] [HGBASE - SRS]
HAPMAP	HERC2 [HAPMAP]
COSMIC	HERC2 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	HERC2
	General knowledge
Family Browser	HERC2 [UCSC Family Browser]
SOURCE	NM_004667
SMD	Hs.610412
SAGE	Hs.610412
Enzyme	6.3.2.- [ Enzyme-SRS ]   6.3.2.- [ Brenda-SRS ]   6.3.2.- [ KEGG ]   6.3.2.- [ WIT ]
GO	ubiquitin-protein ligase activity [Amigo]  ubiquitin-protein ligase activity
GO	ubiquitin-protein ligase activity [Amigo]  ubiquitin-protein ligase activity
GO	guanyl-nucleotide exchange factor activity [Amigo]  guanyl-nucleotide exchange factor activity
GO	cellular_component [Amigo]  cellular_component
GO	intracellular [Amigo]  intracellular
GO	protein modification process [Amigo]  protein modification process
GO	protein modification process [Amigo]  protein modification process
GO	ubiquitin cycle [Amigo]  ubiquitin cycle
GO	ubiquitin cycle [Amigo]  ubiquitin cycle
GO	intracellular protein transport [Amigo]  intracellular protein transport
GO	zinc ion binding [Amigo]  zinc ion binding
GO	ligase activity [Amigo]  ligase activity
GO	heme binding [Amigo]  heme binding
KEGG	Ubiquitin mediated proteolysis
PubGene	HERC2
TreeFam	HERC2
CTD	8924 [Comparative Genomics Database]
	Other databases
	Probes
Probe	HERC2 Related clones (RZPD - Berlin)
	PubMed
PubMed	13 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu May 22 20:10:08 2008