HIC2 (hypermethylated in cancer 2)

Identity

Other names	HRG22
	KIAA1020
	ZBTB30
HGNC	HIC2
Location	22q11.21
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	HIC2   18595
Entrez_Gene	HIC2  23119  hypermethylated in cancer 2
	Cards
GeneCards	HIC2
Ensembl	HIC2 [Search_View]   ENSG00000169635 [Gene_View]
Genatlas	HIC2
GeneLynx	HIC2
eGenome	HIC2
euGene	23119
	Genomic and cartography
GoldenPath	HIC2  -  22q11.21   chr22:20101693-20135750 +  22q11.21   [Description]    (hg18-March_2006)
Ensembl	HIC2 - 22q11.21 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	HIC2
	Gene and transcription
Genbank	AB028943 [ ENTREZ ]
Genbank	AF349035 [ ENTREZ ]
Genbank	AJ313204 [ ENTREZ ]
Genbank	AK023021 [ ENTREZ ]
Genbank	AL162003 [ ENTREZ ]
RefSeq	NM_015094 [ SRS ]    NM_015094 [ ENTREZ ]
RefSeq	AC_000065 [ SRS ]    AC_000065 [ ENTREZ ]
RefSeq	AC_000154 [ SRS ]    AC_000154 [ ENTREZ ]
RefSeq	NC_000022 [ SRS ]    NC_000022 [ ENTREZ ]
RefSeq	NT_011520 [ SRS ]    NT_011520 [ ENTREZ ]
RefSeq	NW_001838744 [ SRS ]    NW_001838744 [ ENTREZ ]
RefSeq	NW_927595 [ SRS ]    NW_927595 [ ENTREZ ]
AceView	HIC2 AceView - NCBI
Unigene	Hs.632767 [ SRS ]    Hs.632767 [ NCBI ]     HS632767 [ spliceNest ]
Fast-db	2055 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q96JB3 [ SRS]    Q96JB3 [ EXPASY ]     Q96JB3 [ INTERPRO ]     Q96JB3 [ UNIPROT ]
Prosite	PS50097 BTB [ SRS ]    PS50097 BTB [ Expasy ]
Prosite	PS00028 ZINC_FINGER_C2H2_1 [ SRS ]    PS00028 ZINC_FINGER_C2H2_1 [ Expasy ]
Prosite	PS50157 ZINC_FINGER_C2H2_2 [ SRS ]    PS50157 ZINC_FINGER_C2H2_2 [ Expasy ]
Interpro	IPR000210 BTB/POZ-like [ SRS ]    IPR000210 BTB/POZ-like [ EBI ]
Interpro	IPR011333 BTB/POZ_fold [ SRS ]    IPR011333 BTB/POZ_fold [ EBI ]
Interpro	IPR013069 BTB_POZ [ SRS ]    IPR013069 BTB_POZ [ EBI ]
Interpro	IPR007087 Znf_C2H2 [ SRS ]    IPR007087 Znf_C2H2 [ EBI ]
Interpro	IPR015880 Znf_C2H2-like [ SRS ]    IPR015880 Znf_C2H2-like [ EBI ]
Interpro	IPR013087 Znf_C2H2/integrase_DNA-bd [ SRS ]    IPR013087 Znf_C2H2/integrase_DNA-bd [ EBI ]
CluSTr	Q96JB3
Pfam	PF00651 BTB [ SRS ]    PF00651 BTB [ Sanger ]    pfam00651 [ NCBI-CDD ]
Pfam	PF00096 zf-C2H2 [ SRS ]    PF00096 zf-C2H2 [ Sanger ]    pfam00096 [ NCBI-CDD ]
Smart	SM00225 BTB [EMBL]
Smart	SM00355 ZnF_C2H2 [EMBL]
Prodom	PD000003 Znf_C2H2[INRA-Toulouse]
Prodom	Q96JB3 HIC2_HUMAN [ Domain structure ]   Q96JB3 HIC2_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q96JB3
HPRD	07412
	Protein Interaction databases
DIP	Q96JB3
IntAct	Q96JB3
	Polymorphism : SNP, mutations, diseases
OMIM	607712    [ map ]
GENECLINICS	607712
SNP	HIC2 [dbSNP-NCBI]
SNP	NM_015094 [SNP-NCI]
SNP	HIC2 [GeneSNPs - Utah]  HIC2] [HGBASE - SRS]
HAPMAP	HIC2 [HAPMAP]
HGMD	HIC2
	General knowledge
Family Browser	HIC2 [UCSC Family Browser]
SOURCE	NM_015094
SMD	Hs.632767
SAGE	Hs.632767
GO	DNA binding [Amigo]  DNA binding
GO	intracellular [Amigo]  intracellular
GO	nucleus [Amigo]  nucleus
GO	transcription [Amigo]  transcription
GO	protein C-terminus binding [Amigo]  protein C-terminus binding
GO	zinc ion binding [Amigo]  zinc ion binding
GO	negative regulation of transcription, DNA-dependent [Amigo]  negative regulation of transcription, DNA-dependent
GO	metal ion binding [Amigo]  metal ion binding
PubGene	HIC2
TreeFam	HIC2
CTD	23119 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	HIC2 Related clones (RZPD - Berlin)
	PubMed
PubMed	12 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:14:08 2008