HK1 (hexokinase 1)

2007-04-01 Affiliation

Identity

HGNC

HK1

LOCATION

10q22.1

LOCUSID

3098

ALIAS

HK,HK1-ta,HK1-tb,HK1-tc,HKD,HKI,HMSNR,HXK1,NEDVIBA,RP79,hexokinase

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3098
MIM: 142600
HGNC: 4922
Ensembl: ENSG00000156515

Variants:

dbSNP: 3098
ClinVar: 3098
TCGA: ENSG00000156515
COSMIC: HK1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000156515	ENST00000298649	P19367
ENSG00000156515	ENST00000359426	P19367
ENSG00000156515	ENST00000360289	P19367
ENSG00000156515	ENST00000421088	B1AR62
ENSG00000156515	ENST00000436817	P19367
ENSG00000156515	ENST00000436817	A0A024QZK7
ENSG00000156515	ENST00000448642	P19367
ENSG00000156515	ENST00000448642	A0A024QZK7
ENSG00000156515	ENST00000450646	P78542
ENSG00000156515	ENST00000464803	A0A2R8Y7T9
ENSG00000156515	ENST00000476368	A0A2R8YEE7
ENSG00000156515	ENST00000493591	A0A2R8Y626
ENSG00000156515	ENST00000643399	P19367
ENSG00000156515	ENST00000643399	A0A024QZK7

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycolysis / Gluconeogenesis	KEGG	ko00010
Fructose and mannose metabolism	KEGG	ko00051
Galactose metabolism	KEGG	ko00052
Starch and sucrose metabolism	KEGG	ko00500
Amino sugar and nucleotide sugar metabolism	KEGG	ko00520
Insulin signaling pathway	KEGG	ko04910
Type II diabetes mellitus	KEGG	ko04930
Glycolysis / Gluconeogenesis	KEGG	hsa00010
Fructose and mannose metabolism	KEGG	hsa00051
Galactose metabolism	KEGG	hsa00052
Starch and sucrose metabolism	KEGG	hsa00500
Amino sugar and nucleotide sugar metabolism	KEGG	hsa00520
Insulin signaling pathway	KEGG	hsa04910
Type II diabetes mellitus	KEGG	hsa04930
Metabolic pathways	KEGG	hsa01100
Neomycin, kanamycin and gentamicin biosynthesis	KEGG	ko00524
Neomycin, kanamycin and gentamicin biosynthesis	KEGG	hsa00524
Carbohydrate digestion and absorption	KEGG	ko04973
Carbohydrate digestion and absorption	KEGG	hsa04973
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate	KEGG	hsa_M00001
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate	KEGG	M00001
Nucleotide sugar biosynthesis, glucose => UDP-glucose	KEGG	hsa_M00549
Nucleotide sugar biosynthesis, glucose => UDP-glucose	KEGG	M00549
HIF-1 signaling pathway	KEGG	hsa04066
Carbon metabolism	KEGG	hsa01200
Carbon metabolism	KEGG	ko01200
Central carbon metabolism in cancer	KEGG	hsa05230
Central carbon metabolism in cancer	KEGG	ko05230
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Hexose transport	REACTOME	R-HSA-189200
Glucose transport	REACTOME	R-HSA-70153
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Glucose metabolism	REACTOME	R-HSA-70326
Glycolysis	REACTOME	R-HSA-70171

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20858683	2010	Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.	170
25904018	2015	Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism.	85
18308720	2008	Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding.	84
16385451	2006	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	69
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
20732627	2010	Case-control genome-wide association study of attention-deficit/hyperactivity disorder.	58
19165527	2009	Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.	56
19049977	2009	Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity.	51
19096518	2008	Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.	48
19096518	2008	Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.	48

Citation

Dessen P

HK1 (hexokinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47112/hk1