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IGF2 (insulin-like growth factor 2 (somatomedin A))

Identity

Other namesC11orf43
FLJ22066
FLJ44734
INSIGF
pp9974
HGNC (Hugo) IGF2
Location 11p15.5
Location_base_pair Starts at 2106923 and ends at 2116780 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IGF2   5466
Entrez_Gene (NCBI)IGF2  3481  insulin-like growth factor 2 (somatomedin A)
Cards
GeneCards (Weizmann)IGF2
Ensembl (Hinxton)ENSG00000167244 [Gene_View]  IGF2 [Vega]
AceView (NCBI)IGF2
Genatlas (Paris)IGF2
euGene (Indiana)3481
SOURCE (Stanford)NM_000612 NM_001007139 NM_001127598
Gene Expression (Array Express) ENSG00000167244
Genomic and cartography
GoldenPath (UCSC)IGF2  -  11p15.5   chr11:2106923-2116780 -  11p15.5   [Description]    (hg18-March_2006)
EnsemblIGF2 - 11p15.5 [CytoView]
Mapping of homologs : NCBIIGF2 [Mapview]
OMIM147470   
Gene and transcription
Gene : Genbank (Entrez)AF318382 AK025719 AK074614 AK126688 AK313938
Reference sequence (RefSeq transcript) :SRSNM_000612 NM_001007139 NM_001127598
Reference transcript : EntrezNM_000612 NM_001007139 NM_001127598
RefSeq genomic : SRSAC_000054 AC_000143 NC_000011 NG_008849 NT_009237 NW_001838018 NW_924962
RefSeq genomic : EntrezAC_000054 AC_000143 NC_000011 NG_008849 NT_009237 NW_001838018 NW_924962
Consensus coding sequences : CCDS NCBIIGF2
Cluster EST : UnigeneHs.718427 [ SRS ] Hs.718427 [ NCBI ]
Alternative Splicing : Fast-db (Paris)829
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtP01344 (SRS) P01344 (Expasy) P01344 (Uniprot)
With graphics : InterProP01344
Splice isoforms : VarSplice FASTAP01344(VarSplice FASTA)
Domaine pattern : Prosite (SRS)INSULIN (PS00262)   
Domain pattern : Prosite (Expaxy)INSULIN (PS00262)   
Domains : Interpro (SRS)IGF2_C    Ins/IGF/relaxin    Insulin-like   
Domains : Interpro (EBI)IGF2_C    Ins/IGF/relaxin    Insulin-like   
Related proteins : CluSTrP01344
Domain families : Pfam SRSIGF2_C (PF08365)    Insulin (PF00049)   
Domain families : Pfam SangerIGF2_C (PF08365)    Insulin (PF00049)   
Domain families : Pfam NCBIpfam08365    pfam00049   
Domain families : Smart EMBLIlGF (SM00078)  
Domain structure : Prodom (Prabi Lyon)IGF2_C (PD005188)   
Blocks (Seattle)P01344
Crystal structure of protein : PDB SRS1GF2    1IGL    2V5P    3E4Z   
Crystal structure of protein : PDBSum1GF2    1IGL    2V5P    3E4Z   
Crystal structure of protein : IMB1GF2    1IGL    2V5P    3E4Z   
Crystal structure of protein : PDB RSDB1GF2    1IGL    2V5P    3E4Z   
HPRD00939
Protein Interaction databases
DIP (DOE-UCLA)P01344
IntAct (EBI)P01344
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIIGF2
SNP : GeneSNP UtahIGF2
SNP : HGBaseIGF2
Genetic variants : HAPMAPIGF2
Somatic Mutations in Cancer : COSMICIGF2 
Mutations and Diseases : HGMDIGF2
Hereditary diseases : OMIM147470   
Hereditary diseases : GENETests147470   
Diseases : Genetic AssociationIGF2
General knowledge
Homologs : HomoloGeneIGF2
Homology/Alignments : Family Browser UCSCIGF2
Phylogenetic Trees/Animal Genes : TreeFamIGF2
Chemical/Protein Interactions : CTD3481
Keywords Ontology : AmiGOskeletal system development  osteoblast differentiation  insulin receptor binding  insulin-like growth factor receptor binding  hormone activity  protein binding  extracellular region  extracellular space  carbohydrate metabolic process  glucose metabolic process  regulation of gene expression by genetic imprinting  multicellular organismal development  growth factor activity  positive regulation of cell proliferation  organ morphogenesis  regulation of gene-specific transcription  positive regulation of MAPKKK cascade  positive regulation of mitosis  positive regulation of insulin receptor signaling pathway  positive regulation of cell division  positive regulation of protein kinase B signaling cascade  
Keywords Ontology : EGO-EBIskeletal system development  osteoblast differentiation  insulin receptor binding  insulin-like growth factor receptor binding  hormone activity  protein binding  extracellular region  extracellular space  carbohydrate metabolic process  glucose metabolic process  regulation of gene expression by genetic imprinting  multicellular organismal development  growth factor activity  positive regulation of cell proliferation  organ morphogenesis  regulation of gene-specific transcription  positive regulation of MAPKKK cascade  positive regulation of mitosis  positive regulation of insulin receptor signaling pathway  positive regulation of cell division  positive regulation of protein kinase B signaling cascade  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesIGF2 Related clones (RZPD - Berlin)
Literature
PubMed274 Pubmed reference(s) in Entrez
PubGeneIGF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:38:50 CET 2010
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