ITGA3 (integrin subunit alpha 3)

2003-05-01  

Identity

HGNC
LOCATION
17q21.33
LOCUSID
ALIAS
CD49C,FRP-2,GAP-B3,GAPB3,ILNEB,MSK18,VCA-2,VL3A,VLA3a
FUSION GENES

Other Information

Locus ID:

NCBI: 3675
MIM: 605025
HGNC: 6139
Ensembl: ENSG00000005884

Variants:

dbSNP: 3675
ClinVar: 3675
TCGA: ENSG00000005884
COSMIC: ITGA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000005884ENST00000007722P26006
ENSG00000005884ENST00000320031P26006
ENSG00000005884ENST00000320031A0A140VJM0
ENSG00000005884ENST00000504417K7EQJ2
ENSG00000005884ENST00000506401D6R9X8
ENSG00000005884ENST00000506827H0YA49
ENSG00000005884ENST00000510809H0YA32
ENSG00000005884ENST00000512553K7EMU3

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Hematopoietic cell lineageKEGGko04640
Regulation of actin cytoskeletonKEGGko04810
Small cell lung cancerKEGGko05222
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
Hematopoietic cell lineageKEGGhsa04640
Regulation of actin cytoskeletonKEGGhsa04810
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
Hypertrophic cardiomyopathy (HCM)KEGGko05410
Hypertrophic cardiomyopathy (HCM)KEGGhsa05410
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Dilated cardiomyopathyKEGGko05414
Dilated cardiomyopathyKEGGhsa05414
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Basigin interactionsREACTOMER-HSA-210991
Signal TransductionREACTOMER-HSA-162582
Extracellular matrix organizationREACTOMER-HSA-1474244
Laminin interactionsREACTOMER-HSA-3000157
Integrin cell surface interactionsREACTOMER-HSA-216083
Signaling by METREACTOMER-HSA-6806834
MET promotes cell motilityREACTOMER-HSA-8875878
MET activates PTK2 signalingREACTOMER-HSA-8874081

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176308332007Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli.106
146020712003Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration.85
119072602002Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology.77
129196772003The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration.73
150240362004Tumor cell alpha3beta1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis.64
225124832012Integrin α3 mutations with kidney, lung, and skin disease.64
165716772006A critical role for tetraspanin CD151 in alpha3beta1 and alpha6beta4 integrin-dependent tumor cell functions on laminin-5.61
197306832009The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.59
162730942005RNA-dependent integrin alpha3 protein localization regulated by the Muscleblind-like protein MLP1.55
192974752009Identification of integrin alpha3 as a new substrate of the adenovirus E4orf6/E1B 55-kilodalton E3 ubiquitin ligase complex.55

Citation

Dessen P

ITGA3 (integrin subunit alpha 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41004/itga3