ITGAM (integrin subunit alpha M)

2003-08-01  

Identity

HGNC
LOCATION
16p11.2
LOCUSID
ALIAS
CD11B,CR3A,MAC-1,MAC1A,MO1A,SLEB6
FUSION GENES

Other Information

Locus ID:

NCBI: 3684
MIM: 120980
HGNC: 6149
Ensembl: ENSG00000169896

Variants:

dbSNP: 3684
ClinVar: 3684
TCGA: ENSG00000169896
COSMIC: ITGAM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169896ENST00000544665P11215
ENSG00000169896ENST00000565142I3NI33
ENSG00000169896ENST00000567031H3BMV4
ENSG00000169896ENST00000648685P11215

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Complement and coagulation cascadesKEGGko04610
Hematopoietic cell lineageKEGGko04640
Leukocyte transendothelial migrationKEGGko04670
Regulation of actin cytoskeletonKEGGko04810
Cell adhesion molecules (CAMs)KEGGhsa04514
Complement and coagulation cascadesKEGGhsa04610
Hematopoietic cell lineageKEGGhsa04640
Leukocyte transendothelial migrationKEGGhsa04670
Regulation of actin cytoskeletonKEGGhsa04810
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
PertussisKEGGko05133
PertussisKEGGhsa05133
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Extracellular matrix organizationREACTOMER-HSA-1474244
Integrin cell surface interactionsREACTOMER-HSA-216083
Neutrophil degranulationREACTOMER-HSA-6798695
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
182044462008Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.488
182044462008Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.488
182040982008Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.309
182040982008Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.309
198337262009CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization.184
253057562014Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens.118
182044482008A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.112
182044482008A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.112
195721482010Population alterations of L-arginase- and inducible nitric oxide synthase-expressed CD11b+/CD14⁻/CD15+/CD33+ myeloid-derived suppressor cells and CD8+ T lymphocytes in patients with advanced-stage non-small cell lung cancer.103
122088822002The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1.102

Citation

Dessen P

ITGAM (integrin subunit alpha M)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41014/itgam