ITGAX (integrin subunit alpha X)

2003-05-01 Affiliation

Identity

HGNC

ITGAX

LOCATION

16p11.2

LOCUSID

3687

ALIAS

CD11C,SLEB6

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3687
MIM: 151510
HGNC: 6152
Ensembl: ENSG00000140678

Variants:

dbSNP: 3687
ClinVar: 3687
TCGA: ENSG00000140678
COSMIC: ITGAX

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000140678	ENST00000268296	P20702
ENSG00000140678	ENST00000562522	H3BN02
ENSG00000140678	ENST00000562918	A0A087X131

Expression (GTEx)

100

150

200

250

300

350

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Complement and coagulation cascades	KEGG	ko04610
Regulation of actin cytoskeleton	KEGG	ko04810
Complement and coagulation cascades	KEGG	hsa04610
Regulation of actin cytoskeleton	KEGG	hsa04810
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Hemostasis	REACTOME	R-HSA-109582
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733
Extracellular matrix organization	REACTOME	R-HSA-1474244
ECM proteoglycans	REACTOME	R-HSA-3000178
Integrin cell surface interactions	REACTOME	R-HSA-216083
Neutrophil degranulation	REACTOME	R-HSA-6798695
Interleukin-4 and 13 signaling	REACTOME	R-HSA-6785807

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
18204098	2008	Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.	309
20479115	2010	Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells.	287
17045822	2006	Activation of leukocyte beta2 integrins by conversion from bent to extended conformations.	102
18386786	2008	CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain.	86
20033057	2010	Structure of an integrin with an alphaI domain, complement receptor type 4.	78
21257965	2011	Two unique human decidual macrophage populations.	66
19910635	2010	CD11c expression in adipose tissue and blood and its role in diet-induced obesity.	62
21030716	2011	CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1.	54
20679211	2010	Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2.	53
19129174	2009	Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).	42

Citation

Dessen P

ITGAX (integrin subunit alpha X)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41016/itgax