ITGB1 (integrin subunit beta 1)

2003-06-01  

Identity

HGNC
LOCATION
10p11.22
LOCUSID
ALIAS
CD29,FNRB,GPIIA,MDF2,MSK12,VLA-BETA,VLAB
FUSION GENES

Other Information

Locus ID:

NCBI: 3688
MIM: 135630
HGNC: 6153
Ensembl: ENSG00000150093

Variants:

dbSNP: 3688
ClinVar: 3688
TCGA: ENSG00000150093
COSMIC: ITGB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000150093ENST00000302278P05556
ENSG00000150093ENST00000396033P05556
ENSG00000150093ENST00000414670Q5T3E4
ENSG00000150093ENST00000417122Q5T3E5
ENSG00000150093ENST00000423113P05556
ENSG00000150093ENST00000437302Q5T3E6
ENSG00000150093ENST00000472147C9JNE0
ENSG00000150093ENST00000474568C9JPK5
ENSG00000150093ENST00000475184E7ERX5
ENSG00000150093ENST00000480226E7EQW5
ENSG00000150093ENST00000488427H7C4K3
ENSG00000150093ENST00000488494E7EUI6
ENSG00000150093ENST00000493758C9JJP8
ENSG00000150093ENST00000494395H7C4N8
ENSG00000150093ENST00000528877E9PQJ2
ENSG00000150093ENST00000534049E9PLR6

Expression (GTEx)

0
100
200
300
400
500
600
700
800

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Cell adhesion molecules (CAMs)KEGGko04514
Tight junctionKEGGko04530
Leukocyte transendothelial migrationKEGGko04670
Regulation of actin cytoskeletonKEGGko04810
Pathogenic Escherichia coli infectionKEGGko05130
Small cell lung cancerKEGGko05222
Axon guidanceKEGGhsa04360
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
Cell adhesion molecules (CAMs)KEGGhsa04514
Tight junctionKEGGhsa04530
Leukocyte transendothelial migrationKEGGhsa04670
Regulation of actin cytoskeletonKEGGhsa04810
Pathogenic Escherichia coli infectionKEGGhsa05130
ShigellosisKEGGhsa05131
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
Hypertrophic cardiomyopathy (HCM)KEGGko05410
Hypertrophic cardiomyopathy (HCM)KEGGhsa05410
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Dilated cardiomyopathyKEGGko05414
Dilated cardiomyopathyKEGGhsa05414
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
Bacterial invasion of epithelial cellsKEGGko05100
Bacterial invasion of epithelial cellsKEGGhsa05100
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
PertussisKEGGko05133
PertussisKEGGhsa05133
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Platelet activationKEGGhsa04611
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
HemostasisREACTOMER-HSA-109582
Platelet Adhesion to exposed collagenREACTOMER-HSA-75892
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Basigin interactionsREACTOMER-HSA-210991
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-extracellular matrix interactionsREACTOMER-HSA-446353
Localization of the PINCH-ILK-PARVIN complex to focal adhesionsREACTOMER-HSA-446343
Extracellular matrix organizationREACTOMER-HSA-1474244
Fibronectin matrix formationREACTOMER-HSA-1566977
Elastic fibre formationREACTOMER-HSA-1566948
Molecules associated with elastic fibresREACTOMER-HSA-2129379
Laminin interactionsREACTOMER-HSA-3000157
Non-integrin membrane-ECM interactionsREACTOMER-HSA-3000171
Syndecan interactionsREACTOMER-HSA-3000170
ECM proteoglycansREACTOMER-HSA-3000178
Integrin cell surface interactionsREACTOMER-HSA-216083
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Other semaphorin interactionsREACTOMER-HSA-416700
L1CAM interactionsREACTOMER-HSA-373760
Signal transduction by L1REACTOMER-HSA-445144
CHL1 interactionsREACTOMER-HSA-447041
Signaling by METREACTOMER-HSA-6806834
MET promotes cell motilityREACTOMER-HSA-8875878
MET activates PTK2 signalingREACTOMER-HSA-8874081
MET interacts with TNS proteinsREACTOMER-HSA-8875513
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
191795332009Mechanically activated integrin switch controls alpha5beta1 function.242
195644062009Demonstration of catch bonds between an integrin and its ligand.209
146754222004Stimulation-dependent recycling of integrin beta1 regulated by ARF6 and Rab11.144
176388912007Hierarchical organization of prostate cancer cells in xenograft tumors: the CD44+alpha2beta1+ cell population is enriched in tumor-initiating cells.141
125177982003Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells.139
173181792007Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent manner.132
126822932003Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins.124
129701732003Structure of integrin alpha5beta1 in complex with fibronectin.123
193595992009TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling.119
192400212009Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects.110

Citation

Dessen P

ITGB1 (integrin subunit beta 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41017/itgb1