ITGB1 (integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12))

Identity

Other names	CD29
	FNRB
	GPIIA
	MDF2
	MSK12
	VLA-BETA
	VLAB
HGNC	ITGB1
Location	10p11.2
Location_base_pair	Starts at 33229252 and ends at 33287299 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	ITGB1   6153
Entrez_Gene	ITGB1  3688  integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
	Cards
GeneCards	ITGB1
Ensembl	ENSG00000150093 [Gene_View]  ITGB1 [Vega]
Genatlas	ITGB1
	Genomic and cartography
GoldenPath	ITGB1  -  10p11.2   chr10:33229252-33287299 -  10p11.22   [Description]    (hg18-March_2006)
Ensembl	ITGB1 - 10p11.22 [CytoView]
NCBI	Mapview
OMIM	135630 Disease map [OMIM]
HomoloGene	ITGB1
	Gene and transcription
Genbank	AF086249 [ ENTREZ ]
Genbank	AI261443 [ ENTREZ ]
Genbank	AK291697 [ ENTREZ ]
Genbank	AL710802 [ ENTREZ ]
Genbank	AM393197 [ ENTREZ ]
RefSeq	NM_002211 [ SRS ]    NM_002211 [ ENTREZ ]
RefSeq	NM_033666 [ SRS ]    NM_033666 [ ENTREZ ]
RefSeq	NM_033667 [ SRS ]    NM_033667 [ ENTREZ ]
RefSeq	NM_033668 [ SRS ]    NM_033668 [ ENTREZ ]
RefSeq	NM_033669 [ SRS ]    NM_033669 [ ENTREZ ]
RefSeq	NM_133376 [ SRS ]    NM_133376 [ ENTREZ ]
RefSeq	AC_000053 [ SRS ]    AC_000053 [ ENTREZ ]
RefSeq	AC_000142 [ SRS ]    AC_000142 [ ENTREZ ]
RefSeq	NC_000010 [ SRS ]    NC_000010 [ ENTREZ ]
RefSeq	NT_008705 [ SRS ]    NT_008705 [ ENTREZ ]
RefSeq	NW_001837932 [ SRS ]    NW_001837932 [ ENTREZ ]
RefSeq	NW_924584 [ SRS ]    NW_924584 [ ENTREZ ]
CCDS	ITGB1 CCDS - NCBI
AceView	ITGB1 AceView - NCBI
Unigene	Hs.713531 [ SRS ]    Hs.713531 [ NCBI ]
Fast-db	8169 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P05556 [ SRS]    P05556 [ EXPASY ]     P05556 [ INTERPRO ]     P05556 [ UNIPROT ] P05556 [ VarSplice FASTA ]
Prosite	PS00022 EGF_1 [ SRS ]    PS00022 EGF_1 [ Expasy ]
Prosite	PS00243 INTEGRIN_BETA [ SRS ]    PS00243 INTEGRIN_BETA [ Expasy ]
Prosite	PS50234 VWFA [ SRS ]    PS50234 VWFA [ Expasy ]
Interpro	IPR013111 EGF_extracell [ SRS ]    IPR013111 EGF_extracell [ EBI ]
Interpro	IPR013032 EGF_like_reg_CS [ SRS ]    IPR013032 EGF_like_reg_CS [ EBI ]
Interpro	IPR015812 Integrin_bsu [ SRS ]    IPR015812 Integrin_bsu [ EBI ]
Interpro	IPR015438 Integrin_bsu-1_C [ SRS ]    IPR015438 Integrin_bsu-1_C [ EBI ]
Interpro	IPR001169 Integrin_bsu_C [ SRS ]    IPR001169 Integrin_bsu_C [ EBI ]
Interpro	IPR014836 Integrin_bsu_cyt [ SRS ]    IPR014836 Integrin_bsu_cyt [ EBI ]
Interpro	IPR002369 Integrin_bsu_N [ SRS ]    IPR002369 Integrin_bsu_N [ EBI ]
Interpro	IPR012012 Integrin_bsu_subgr [ SRS ]    IPR012012 Integrin_bsu_subgr [ EBI ]
Interpro	IPR012896 Integrin_bsu_tail [ SRS ]    IPR012896 Integrin_bsu_tail [ EBI ]
Interpro	IPR003659 Plexin-like [ SRS ]    IPR003659 Plexin-like [ EBI ]
Interpro	IPR002035 VWF_A [ SRS ]    IPR002035 VWF_A [ EBI ]
CluSTr	P05556
Pfam	PF07974 EGF_2 [ SRS ]    PF07974 EGF_2 [ Sanger ]    pfam07974 [ NCBI-CDD ]
Pfam	PF08725 Integrin_b_cyt [ SRS ]    PF08725 Integrin_b_cyt [ Sanger ]    pfam08725 [ NCBI-CDD ]
Pfam	PF07965 Integrin_B_tail [ SRS ]    PF07965 Integrin_B_tail [ Sanger ]    pfam07965 [ NCBI-CDD ]
Pfam	PF00362 Integrin_beta [ SRS ]    PF00362 Integrin_beta [ Sanger ]    pfam00362 [ NCBI-CDD ]
Smart	SM00187 INB [EMBL]
Smart	SM00423 PSI [EMBL]
Smart	SM00327 VWA [EMBL]
Blocks	P05556
PDB	1K11 [ SRS ]    1K11 [ PdbSum ],   1K11 [ IMB ]   1K11 [ RSDB ]
PDB	1LHA [ SRS ]    1LHA [ PdbSum ],   1LHA [ IMB ]   1LHA [ RSDB ]
HPRD	00628
	Protein Interaction databases
DIP	P05556
IntAct	P05556
	Polymorphism : SNP, mutations, diseases
OMIM	135630    [ map ]
GENETests	135630
SNP	ITGB1 [dbSNP-NCBI]
SNP	NM_002211 [SNP-NCI]
SNP	NM_033666 [SNP-NCI]
SNP	NM_033667 [SNP-NCI]
SNP	NM_033668 [SNP-NCI]
SNP	NM_033669 [SNP-NCI]
SNP	NM_133376 [SNP-NCI]
SNP	ITGB1 [GeneSNPs - Utah]  ITGB1] [HGBASE - SRS]
HAPMAP	ITGB1 [HAPMAP]
COSMIC	ITGB1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	ITGB1
Genetic Association	ITGB1
CDC HuGE	ITGB1
	General knowledge
Family Browser	ITGB1 [UCSC Family Browser]
SOURCE	NM_002211
SOURCE	NM_033666
SOURCE	NM_033667
SOURCE	NM_033668
SOURCE	NM_033669
SOURCE	NM_133376
SMD	Hs.713531
SAGE	Hs.713531
GO	ruffle [Amigo]  ruffle
GO	receptor activity [Amigo]  receptor activity
GO	binding [Amigo]  binding
GO	protein binding [Amigo]  protein binding
GO	endoplasmic reticulum [Amigo]  endoplasmic reticulum
GO	cellular defense response [Amigo]  cellular defense response
GO	cell adhesion [Amigo]  cell adhesion
GO	homophilic cell adhesion [Amigo]  homophilic cell adhesion
GO	leukocyte adhesion [Amigo]  leukocyte adhesion
GO	cell-matrix adhesion [Amigo]  cell-matrix adhesion
GO	integrin-mediated signaling pathway [Amigo]  integrin-mediated signaling pathway
GO	integrin complex [Amigo]  integrin complex
GO	integrin complex [Amigo]  integrin complex
GO	cell surface [Amigo]  cell surface
GO	membrane [Amigo]  membrane
GO	integral to membrane [Amigo]  integral to membrane
GO	cell migration [Amigo]  cell migration
GO	B cell differentiation [Amigo]  B cell differentiation
GO	neuromuscular junction [Amigo]  neuromuscular junction
GO	sarcolemma [Amigo]  sarcolemma
GO	melanosome [Amigo]  melanosome
GO	identical protein binding [Amigo]  identical protein binding
GO	interspecies interaction between organisms [Amigo]  interspecies interaction between organisms
GO	protein heterodimerization activity [Amigo]  protein heterodimerization activity
BIOCARTA	Cells and Molecules involved in local acute inflammatory response    [Genes]
BIOCARTA	Agrin in Postsynaptic Differentiation    [Genes]
BIOCARTA	B Cell Survival Pathway    [Genes]
BIOCARTA	Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia    [Genes]
BIOCARTA	Eph Kinases and ephrins support platelet aggregation    [Genes]
BIOCARTA	Erk1/Erk2 Mapk Signaling pathway    [Genes]
BIOCARTA	Integrin Signaling Pathway    [Genes]
BIOCARTA	Adhesion and Diapedesis of Lymphocytes    [Genes]
BIOCARTA	Adhesion Molecules on Lymphocyte    [Genes]
BIOCARTA	mCalpain and friends in Cell motility    [Genes]
BIOCARTA	Signaling of Hepatocyte Growth Factor Receptor    [Genes]
BIOCARTA	Monocyte and its Surface Molecules    [Genes]
BIOCARTA	Ras-Independent pathway in NK cell-mediated cytotoxicity    [Genes]
BIOCARTA	PTEN dependent cell cycle arrest and apoptosis    [Genes]
BIOCARTA	Aspirin Blocks Signaling Pathway Involved in Platelet Activation    [Genes]
BIOCARTA	Trefoil Factors Initiate Mucosal Healing    [Genes]
BIOCARTA	uCalpain and friends in Cell spread    [Genes]
KEGG	Axon guidance
KEGG	Focal adhesion
KEGG	ECM-receptor interaction
KEGG	Cell adhesion molecules (CAMs)
KEGG	Leukocyte transendothelial migration
KEGG	Regulation of actin cytoskeleton
PubGene	ITGB1
TreeFam	ITGB1
CTD	3688 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ITGB1 Related clones (RZPD - Berlin)
	PubMed
PubMed	432 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu Nov 27 13:53:09 2008