ITGB2 (integrin subunit beta 2)

2003-05-01 Affiliation

Identity

HGNC

ITGB2

LOCATION

21q22.3

LOCUSID

3689

ALIAS

CD18,LAD,LCAMB,LFA-1,MAC-1,MF17,MFI7

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3689
MIM: 600065
HGNC: 6155
Ensembl: ENSG00000160255

Variants:

dbSNP: 3689
ClinVar: 3689
TCGA: ENSG00000160255
COSMIC: ITGB2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000160255	ENST00000302347	P05107
ENSG00000160255	ENST00000320216	J3KNI6
ENSG00000160255	ENST00000355153	P05107
ENSG00000160255	ENST00000397846	A8MVG7
ENSG00000160255	ENST00000397850	P05107
ENSG00000160255	ENST00000397852	P05107
ENSG00000160255	ENST00000397854	D3DSM0
ENSG00000160255	ENST00000397857	P05107
ENSG00000160255	ENST00000517563	E5RIG7
ENSG00000160255	ENST00000517819	E5RFI0
ENSG00000160255	ENST00000520389	E5RIE4
ENSG00000160255	ENST00000521995	E5RHT0
ENSG00000160255	ENST00000522688	E5RK54
ENSG00000160255	ENST00000522931	E5RK25
ENSG00000160255	ENST00000523323	E5RGK9
ENSG00000160255	ENST00000523663	E7EVZ9
ENSG00000160255	ENST00000524251	E5RHE6
ENSG00000160255	ENST00000652462	A0A494C0X7

Expression (GTEx)

100

200

300

400

500

600

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell adhesion molecules (CAMs)	KEGG	ko04514
Complement and coagulation cascades	KEGG	ko04610
Natural killer cell mediated cytotoxicity	KEGG	ko04650
Leukocyte transendothelial migration	KEGG	ko04670
Regulation of actin cytoskeleton	KEGG	ko04810
Cell adhesion molecules (CAMs)	KEGG	hsa04514
Complement and coagulation cascades	KEGG	hsa04610
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
Leukocyte transendothelial migration	KEGG	hsa04670
Regulation of actin cytoskeleton	KEGG	hsa04810
Viral myocarditis	KEGG	hsa05416
Leishmaniasis	KEGG	ko05140
Leishmaniasis	KEGG	hsa05140
Malaria	KEGG	ko05144
Malaria	KEGG	hsa05144
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Amoebiasis	KEGG	ko05146
Amoebiasis	KEGG	hsa05146
Staphylococcus aureus infection	KEGG	ko05150
Staphylococcus aureus infection	KEGG	hsa05150
Rheumatoid arthritis	KEGG	ko05323
Rheumatoid arthritis	KEGG	hsa05323
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Pertussis	KEGG	ko05133
Pertussis	KEGG	hsa05133
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Legionellosis	KEGG	ko05134
Legionellosis	KEGG	hsa05134
Hippo signaling pathway	KEGG	hsa04390
Hippo signaling pathway	KEGG	ko04390
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	REACTOME	R-HSA-198933
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Hemostasis	REACTOME	R-HSA-109582
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733
Extracellular matrix organization	REACTOME	R-HSA-1474244
Integrin cell surface interactions	REACTOME	R-HSA-216083
Neutrophil degranulation	REACTOME	R-HSA-6798695
Interleukin-4 and 13 signaling	REACTOME	R-HSA-6785807

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
22156198	2012	A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1.	222
21597477	2011	The insider's guide to leukocyte integrin signalling and function.	165
20511548	2010	Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype.	155
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
11896403	2002	Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation.	83
15485828	2005	Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2.	83
20033057	2010	Structure of an integrin with an alphaI domain, complement receptor type 4.	78
20362473	2010	Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins.	66
20445017	2010	Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils.	66

Citation

Dessen P

ITGB2 (integrin subunit beta 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41018/itgb2