ITGB2 (integrin, beta 2 (complement component 3 receptor 3 and 4 subunit))

Identity

Other names	CD18
	LAD
	LCAMB
	LFA-1
	MAC-1
	MF17
	MFI7
HGNC	ITGB2
Location	21q22.3
Location_base_pair	Starts at 45130297 and ends at 45165393 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	ITGB2   6155
Entrez_Gene	ITGB2  3689  integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
	Cards
GeneCards	ITGB2
Ensembl	ITGB2 [Search_View]   ENSG00000160255 [Gene_View]
Genatlas	ITGB2
GeneLynx	ITGB2
eGenome	ITGB2
euGene	3689
	Genomic and cartography
GoldenPath	ITGB2  -  21q22.3   chr21:45130297-45165393 -  21q22.3   [Description]    (hg18-March_2006)
Ensembl	ITGB2 - 21q22.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	ITGB2
	Gene and transcription
Genbank	AB208909 [ ENTREZ ]
Genbank	AK095992 [ ENTREZ ]
Genbank	AK097216 [ ENTREZ ]
Genbank	AK097864 [ ENTREZ ]
Genbank	AK128344 [ ENTREZ ]
RefSeq	NM_000211 [ SRS ]    NM_000211 [ ENTREZ ]
RefSeq	NM_001127491 [ SRS ]    NM_001127491 [ ENTREZ ]
RefSeq	AC_000064 [ SRS ]    AC_000064 [ ENTREZ ]
RefSeq	AC_000153 [ SRS ]    AC_000153 [ ENTREZ ]
RefSeq	NC_000021 [ SRS ]    NC_000021 [ ENTREZ ]
RefSeq	NG_007270 [ SRS ]    NG_007270 [ ENTREZ ]
RefSeq	NT_011515 [ SRS ]    NT_011515 [ ENTREZ ]
RefSeq	NW_001838716 [ SRS ]    NW_001838716 [ ENTREZ ]
RefSeq	NW_927384 [ SRS ]    NW_927384 [ ENTREZ ]
AceView	ITGB2 AceView - NCBI
Unigene	Hs.375957 [ SRS ]    Hs.375957 [ NCBI ]     HS375957 [ spliceNest ]
Fast-db	4189 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P05107 [ SRS]    P05107 [ EXPASY ]     P05107 [ INTERPRO ]     P05107 [ UNIPROT ]
Prosite	PS00022 EGF_1 [ SRS ]    PS00022 EGF_1 [ Expasy ]
Prosite	PS01186 EGF_2 [ SRS ]    PS01186 EGF_2 [ Expasy ]
Prosite	PS00243 INTEGRIN_BETA [ SRS ]    PS00243 INTEGRIN_BETA [ Expasy ]
Prosite	PS50234 VWFA [ SRS ]    PS50234 VWFA [ Expasy ]
Interpro	IPR013111 EGF_extracell [ SRS ]    IPR013111 EGF_extracell [ EBI ]
Interpro	IPR013032 EGF_like_reg_CS [ SRS ]    IPR013032 EGF_like_reg_CS [ EBI ]
Interpro	IPR015812 Integrin_bsu [ SRS ]    IPR015812 Integrin_bsu [ EBI ]
Interpro	IPR015439 Integrin_bsu-2_C [ SRS ]    IPR015439 Integrin_bsu-2_C [ EBI ]
Interpro	IPR001169 Integrin_bsu_C [ SRS ]    IPR001169 Integrin_bsu_C [ EBI ]
Interpro	IPR014836 Integrin_bsu_cyt [ SRS ]    IPR014836 Integrin_bsu_cyt [ EBI ]
Interpro	IPR002369 Integrin_bsu_N [ SRS ]    IPR002369 Integrin_bsu_N [ EBI ]
Interpro	IPR012012 Integrin_bsu_subgr [ SRS ]    IPR012012 Integrin_bsu_subgr [ EBI ]
Interpro	IPR012896 Integrin_bsu_tail [ SRS ]    IPR012896 Integrin_bsu_tail [ EBI ]
Interpro	IPR003659 Plexin-like [ SRS ]    IPR003659 Plexin-like [ EBI ]
Interpro	IPR002035 VWF_A [ SRS ]    IPR002035 VWF_A [ EBI ]
CluSTr	P05107
Pfam	PF07974 EGF_2 [ SRS ]    PF07974 EGF_2 [ Sanger ]    pfam07974 [ NCBI-CDD ]
Pfam	PF08725 Integrin_b_cyt [ SRS ]    PF08725 Integrin_b_cyt [ Sanger ]    pfam08725 [ NCBI-CDD ]
Pfam	PF07965 Integrin_B_tail [ SRS ]    PF07965 Integrin_B_tail [ Sanger ]    pfam07965 [ NCBI-CDD ]
Pfam	PF00362 Integrin_beta [ SRS ]    PF00362 Integrin_beta [ Sanger ]    pfam00362 [ NCBI-CDD ]
Smart	SM00187 INB [EMBL]
Smart	SM00423 PSI [EMBL]
Smart	SM00327 VWA [EMBL]
Blocks	P05107
PDB	1JX3 [ SRS ]    1JX3 [ PdbSum ],   1JX3 [ IMB ]   1JX3 [ RSDB ]
PDB	1L3Y [ SRS ]    1L3Y [ PdbSum ],   1L3Y [ IMB ]   1L3Y [ RSDB ]
PDB	1YUK [ SRS ]    1YUK [ PdbSum ],   1YUK [ IMB ]   1YUK [ RSDB ]
PDB	2JF1 [ SRS ]    2JF1 [ PdbSum ],   2JF1 [ IMB ]   2JF1 [ RSDB ]
PDB	2P26 [ SRS ]    2P26 [ PdbSum ],   2P26 [ IMB ]   2P26 [ RSDB ]
PDB	2P28 [ SRS ]    2P28 [ PdbSum ],   2P28 [ IMB ]   2P28 [ RSDB ]
HPRD	02506
	Protein Interaction databases
DIP	P05107
IntAct	P05107
	Polymorphism : SNP, mutations, diseases
OMIM	116920;600065    [ map ]
GENECLINICS	116920;600065
SNP	ITGB2 [dbSNP-NCBI]
SNP	NM_000211 [SNP-NCI]
SNP	NM_001127491 [SNP-NCI]
SNP	ITGB2 [GeneSNPs - Utah]  ITGB2] [HGBASE - SRS]
HAPMAP	ITGB2 [HAPMAP]
COSMIC	ITGB2 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	ITGB2
	General knowledge
Family Browser	ITGB2 [UCSC Family Browser]
SOURCE	NM_000211
SOURCE	NM_001127491
SMD	Hs.375957
SAGE	Hs.375957
GO	receptor activity [Amigo]  receptor activity
GO	binding [Amigo]  binding
GO	protein binding [Amigo]  protein binding
GO	plasma membrane [Amigo]  plasma membrane
GO	apoptosis [Amigo]  apoptosis
GO	inflammatory response [Amigo]  inflammatory response
GO	cell adhesion [Amigo]  cell adhesion
GO	cell adhesion [Amigo]  cell adhesion
GO	leukocyte adhesion [Amigo]  leukocyte adhesion
GO	cell-matrix adhesion [Amigo]  cell-matrix adhesion
GO	integrin-mediated signaling pathway [Amigo]  integrin-mediated signaling pathway
GO	integrin-mediated signaling pathway [Amigo]  integrin-mediated signaling pathway
GO	cell-cell signaling [Amigo]  cell-cell signaling
GO	integrin complex [Amigo]  integrin complex
GO	integrin complex [Amigo]  integrin complex
GO	regulation of cell shape [Amigo]  regulation of cell shape
GO	membrane [Amigo]  membrane
GO	integral to membrane [Amigo]  integral to membrane
GO	protein kinase binding [Amigo]  protein kinase binding
GO	neutrophil chemotaxis [Amigo]  neutrophil chemotaxis
GO	regulation of peptidyl-tyrosine phosphorylation [Amigo]  regulation of peptidyl-tyrosine phosphorylation
KEGG	Cell adhesion molecules (CAMs)
KEGG	Natural killer cell mediated cytotoxicity
KEGG	Leukocyte transendothelial migration
KEGG	Regulation of actin cytoskeleton
PubGene	ITGB2
TreeFam	ITGB2
CTD	3689 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ITGB2 Related clones (RZPD - Berlin)
	PubMed
PubMed	197 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 14:47:07 2008