KDR (kinase insert domain receptor (a type III receptor tyrosine kinase))

Identity

Other names	CD309
	FLK1
	VEGFR
	VEGFR2
HGNC	KDR
Location	4q11-q12
Location_base_pair	Starts at 55639406 and ends at 55686519 bp from pter (hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	KDR   6307
Entrez_Gene	KDR  3791  kinase insert domain receptor (a type III receptor tyrosine kinase)
	Cards
GeneCards	KDR
Ensembl	KDR [Search_View]   ENSG00000128052 [Gene_View]
Genatlas	KDR
GeneLynx	KDR
eGenome	KDR
euGene	3791
	Genomic and cartography
GoldenPath	KDR  -     chr4:55639406-55686519 -  4q12   [Description]    (hg18-March_2006)
Ensembl	KDR - 4q12 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	KDR
	Gene and transcription
Genbank	AB209901 [ ENTREZ ]
Genbank	AF035121 [ ENTREZ ]
Genbank	AF063658 [ ENTREZ ]
Genbank	BC131822 [ ENTREZ ]
Genbank	BP280621 [ ENTREZ ]
RefSeq	NM_002253 [ SRS ]    NM_002253 [ ENTREZ ]
RefSeq	AC_000047 [ SRS ]    AC_000047 [ ENTREZ ]
RefSeq	AC_000136 [ SRS ]    AC_000136 [ ENTREZ ]
RefSeq	NC_000004 [ SRS ]    NC_000004 [ ENTREZ ]
RefSeq	NT_022853 [ SRS ]    NT_022853 [ ENTREZ ]
RefSeq	NW_001838913 [ SRS ]    NW_001838913 [ ENTREZ ]
RefSeq	NW_922162 [ SRS ]    NW_922162 [ ENTREZ ]
AceView	KDR AceView - NCBI
Unigene	Hs.479756 [ SRS ]    Hs.479756 [ NCBI ]     HS479756 [ spliceNest ]
Fast-db	4423 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P35968 [ SRS]    P35968 [ EXPASY ]     P35968 [ INTERPRO ]     P35968 [ UNIPROT ]
Prosite	PS50835 IG_LIKE [ SRS ]    PS50835 IG_LIKE [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00109 PROTEIN_KINASE_TYR [ SRS ]    PS00109 PROTEIN_KINASE_TYR [ Expasy ]
Prosite	PS00240 RECEPTOR_TYR_KIN_III [ SRS ]    PS00240 RECEPTOR_TYR_KIN_III [ Expasy ]
Interpro	IPR007110 Ig-like [ SRS ]    IPR007110 Ig-like [ EBI ]
Interpro	IPR013783 Ig-like_fold [ SRS ]    IPR013783 Ig-like_fold [ EBI ]
Interpro	IPR013098 Ig_I-set [ SRS ]    IPR013098 Ig_I-set [ EBI ]
Interpro	IPR003599 Ig_sub [ SRS ]    IPR003599 Ig_sub [ EBI ]
Interpro	IPR003598 Ig_sub2 [ SRS ]    IPR003598 Ig_sub2 [ EBI ]
Interpro	IPR013106 Ig_V-set [ SRS ]    IPR013106 Ig_V-set [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR001824 Recept_tyr_kinase-III_CS [ SRS ]    IPR001824 Recept_tyr_kinase-III_CS [ EBI ]
Interpro	IPR001245 Tyr_pkinase [ SRS ]    IPR001245 Tyr_pkinase [ EBI ]
Interpro	IPR008266 Tyr_pkinase_AS [ SRS ]    IPR008266 Tyr_pkinase_AS [ EBI ]
Interpro	IPR009136 VEGFR2 [ SRS ]    IPR009136 VEGFR2 [ EBI ]
Interpro	IPR009134 VEGFR_N [ SRS ]    IPR009134 VEGFR_N [ EBI ]
CluSTr	P35968
Pfam	PF07679 I-set [ SRS ]    PF07679 I-set [ Sanger ]    pfam07679 [ NCBI-CDD ]
Pfam	PF07714 Pkinase_Tyr [ SRS ]    PF07714 Pkinase_Tyr [ Sanger ]    pfam07714 [ NCBI-CDD ]
Pfam	PF07686 V-set [ SRS ]    PF07686 V-set [ Sanger ]    pfam07686 [ NCBI-CDD ]
Smart	SM00409 IG [EMBL]
Smart	SM00408 IGc2 [EMBL]
Smart	SM00219 TyrKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	P35968 VGFR2_HUMAN [ Domain structure ]   P35968 VGFR2_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P35968
PDB	1VR2 [ SRS ]    1VR2 [ PdbSum ],   1VR2 [ IMB ]   1VR2 [ RSDB ]
PDB	1Y6A [ SRS ]    1Y6A [ PdbSum ],   1Y6A [ IMB ]   1Y6A [ RSDB ]
PDB	1Y6B [ SRS ]    1Y6B [ PdbSum ],   1Y6B [ IMB ]   1Y6B [ RSDB ]
PDB	1YWN [ SRS ]    1YWN [ PdbSum ],   1YWN [ IMB ]   1YWN [ RSDB ]
PDB	2P2H [ SRS ]    2P2H [ PdbSum ],   2P2H [ IMB ]   2P2H [ RSDB ]
PDB	2P2I [ SRS ]    2P2I [ PdbSum ],   2P2I [ IMB ]   2P2I [ RSDB ]
HPRD	01867
	Protein Interaction databases
DIP	P35968
IntAct	P35968
	Polymorphism : SNP, mutations, diseases
OMIM	191306;602089    [ map ]
GENECLINICS	191306;602089
SNP	KDR [dbSNP-NCBI]
SNP	NM_002253 [SNP-NCI]
SNP	KDR [GeneSNPs - Utah]  KDR] [HGBASE - SRS]
HAPMAP	KDR [HAPMAP]
COSMIC	KDR [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	KDR
	General knowledge
Family Browser	KDR [UCSC Family Browser]
SOURCE	NM_002253
SMD	Hs.479756
SAGE	Hs.479756
Enzyme	2.7.10.1 [ Enzyme-Expasy ]   2.7.10.1 [ Enzyme-SRS ]   2.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   2.7.10.1 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	angiogenesis [Amigo]  angiogenesis
GO	receptor activity [Amigo]  receptor activity
GO	vascular endothelial growth factor receptor activity [Amigo]  vascular endothelial growth factor receptor activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	integral to plasma membrane [Amigo]  integral to plasma membrane
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	transmembrane receptor protein tyrosine kinase signaling pathway [Amigo]  transmembrane receptor protein tyrosine kinase signaling pathway
GO	multicellular organismal development [Amigo]  multicellular organismal development
GO	membrane [Amigo]  membrane
GO	transferase activity [Amigo]  transferase activity
GO	cell differentiation [Amigo]  cell differentiation
GO	interspecies interaction between organisms [Amigo]  interspecies interaction between organisms
BIOCARTA	Actions of Nitric Oxide in the Heart    [Genes]
BIOCARTA	VEGF, Hypoxia, and Angiogenesis    [Genes]
KEGG	Cytokine-cytokine receptor interaction
KEGG	VEGF signaling pathway
KEGG	Focal adhesion
PubGene	KDR
TreeFam	KDR
CTD	3791 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	KDR Related clones (RZPD - Berlin)
	PubMed
PubMed	214 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 13:18:46 2008