KRT8 (keratin 8)

2007-02-01  

Identity

HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
CARD2,CK-8,CK8,CYK8,K2C8,K8,KO
FUSION GENES

Other Information

Locus ID:

NCBI: 3856
MIM: 148060
HGNC: 6446
Ensembl: ENSG00000170421

Variants:

dbSNP: 3856
ClinVar: 3856
TCGA: ENSG00000170421
COSMIC: KRT8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170421ENST00000293308P05787
ENSG00000170421ENST00000546542F8VQY3
ENSG00000170421ENST00000546826F8VUG2
ENSG00000170421ENST00000546897P05787
ENSG00000170421ENST00000546900F8VP67
ENSG00000170421ENST00000547176H0YIB2
ENSG00000170421ENST00000548998F8W1U3
ENSG00000170421ENST00000552150P05787
ENSG00000170421ENST00000552551P05787
ENSG00000170421ENST00000619952A0A0U1RQU6

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
168187232006A disease- and phosphorylation-related nonmechanical function for keratin 8.70
192047262009Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.63
234499732013Keratin 8 and 18 loss in epithelial cancer cells increases collective cell migration and cisplatin sensitivity through claudin1 up-regulation.62
159728202005Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells.49
151944212004Keratin 8/18 breakdown and reorganization during apoptosis.45
117885832002Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation.42
172132002007Interleukin-6 induces keratin expression in intestinal epithelial cells: potential role of keratin-8 in interleukin-6-induced barrier function alterations.40
170347882006CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation.39
117813242002The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase.34
205380002010Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations.32

Citation

Dessen P

KRT8 (keratin 8)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45828/krt8