LAMC1 (laminin subunit gamma 1)

2003-06-01  

Identity

HGNC
LOCATION
1q25.3
LOCUSID
ALIAS
LAMB2
FUSION GENES

Other Information

Locus ID:

NCBI: 3915
MIM: 150290
HGNC: 6492
Ensembl: ENSG00000135862

Variants:

dbSNP: 3915
ClinVar: 3915
TCGA: ENSG00000135862
COSMIC: LAMC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135862ENST00000258341P11047
ENSG00000135862ENST00000484114R4GNC7

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Small cell lung cancerKEGGko05222
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
Prion diseasesKEGGko05020
Prion diseasesKEGGhsa05020
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Signal TransductionREACTOMER-HSA-162582
Extracellular matrix organizationREACTOMER-HSA-1474244
Laminin interactionsREACTOMER-HSA-3000157
Non-integrin membrane-ECM interactionsREACTOMER-HSA-3000171
ECM proteoglycansREACTOMER-HSA-3000178
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Signaling by METREACTOMER-HSA-6806834
MET promotes cell motilityREACTOMER-HSA-8875878
MET activates PTK2 signalingREACTOMER-HSA-8874081

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
232665562013Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.172
194168972009Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy.58
248200272014Tumor-suppressive microRNA-29s inhibit cancer cell migration and invasion via targeting LAMC1 in prostate cancer.45
280393272017A functional polymorphism located at transcription factor binding sites, rs6695837 near LAMC1 gene, confers risk of colorectal cancer in Chinese populations.38
127430342003Laminin-10 is crucial for hair morphogenesis.33
118912252002Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via phosphatidylinositol 3-kinase/Akt- and MEK1/ERK-dependent pathways.30
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
198345352009Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.27
159671152005Membrane type 1 matrix metalloprotease cleaves laminin-10 and promotes prostate cancer cell migration.26
170218622007Sequence variant in the laminin gamma1 (LAMC1) gene associated with familial pelvic organ prolapse.24

Citation

Dessen P

LAMC1 (laminin subunit gamma 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41118/lamc1