LATS1 (LATS, large tumor suppressor, homolog 1 (Drosophila))

Identity

Other names	WARTS
	wts
HGNC	LATS1
Location	6q25.1
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	LATS1   6514
Entrez_Gene	LATS1  9113  LATS, large tumor suppressor, homolog 1 (Drosophila)
	Cards
GeneCards	LATS1
Ensembl	LATS1 [Search_View]   ENSG00000131023 [Gene_View]
Genatlas	LATS1
GeneLynx	LATS1
eGenome	LATS1
euGene	9113
	Genomic and cartography
GoldenPath	LATS1  -  6q25.1   chr6:150023744-150081085 -  6q25.1   [Description]    (hg18-March_2006)
Ensembl	LATS1 - 6q25.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	LATS1
	Gene and transcription
Genbank	AF104413 [ ENTREZ ]
Genbank	AF164041 [ ENTREZ ]
Genbank	AK310422 [ ENTREZ ]
Genbank	BC002767 [ ENTREZ ]
Genbank	BC015665 [ ENTREZ ]
RefSeq	NM_004690 [ SRS ]    NM_004690 [ ENTREZ ]
RefSeq	AC_000049 [ SRS ]    AC_000049 [ ENTREZ ]
RefSeq	AC_000138 [ SRS ]    AC_000138 [ ENTREZ ]
RefSeq	NC_000006 [ SRS ]    NC_000006 [ ENTREZ ]
RefSeq	NT_025741 [ SRS ]    NT_025741 [ ENTREZ ]
RefSeq	NW_001838990 [ SRS ]    NW_001838990 [ ENTREZ ]
RefSeq	NW_923184 [ SRS ]    NW_923184 [ ENTREZ ]
AceView	LATS1 AceView - NCBI
Unigene	Hs.549084 [ SRS ]    Hs.549084 [ NCBI ]     HS549084 [ spliceNest ]
Fast-db	16777 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O95835 [ SRS]    O95835 [ EXPASY ]     O95835 [ INTERPRO ]     O95835 [ UNIPROT ]
Prosite	PS51285 AGC_KINASE_CTER [ SRS ]    PS51285 AGC_KINASE_CTER [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Prosite	PS50030 UBA [ SRS ]    PS50030 UBA [ Expasy ]
Interpro	IPR000961 Pkinase_C [ SRS ]    IPR000961 Pkinase_C [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR002290 Ser_thr_pkinase [ SRS ]    IPR002290 Ser_thr_pkinase [ EBI ]
Interpro	IPR000449 UBA/transl_elong_EF1B_N [ SRS ]    IPR000449 UBA/transl_elong_EF1B_N [ EBI ]
Interpro	IPR015940 UBA/transl_elong_EF1B_N_euk [ SRS ]    IPR015940 UBA/transl_elong_EF1B_N_euk [ EBI ]
CluSTr	O95835
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Pfam	PF00433 Pkinase_C [ SRS ]    PF00433 Pkinase_C [ Sanger ]    pfam00433 [ NCBI-CDD ]
Pfam	PF00627 UBA [ SRS ]    PF00627 UBA [ Sanger ]    pfam00627 [ NCBI-CDD ]
Smart	SM00133 S_TK_X [EMBL]
Smart	SM00220 S_TKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	O95835 LATS1_HUMAN [ Domain structure ]   O95835 LATS1_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	O95835
HPRD	09147
	Protein Interaction databases
DIP	O95835
IntAct	O95835
	Polymorphism : SNP, mutations, diseases
OMIM	603473    [ map ]
GENECLINICS	603473
SNP	LATS1 [dbSNP-NCBI]
SNP	NM_004690 [SNP-NCI]
SNP	LATS1 [GeneSNPs - Utah]  LATS1] [HGBASE - SRS]
HAPMAP	LATS1 [HAPMAP]
COSMIC	LATS1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	LATS1
	General knowledge
Family Browser	LATS1 [UCSC Family Browser]
SOURCE	NM_004690
SMD	Hs.549084
SAGE	Hs.549084
Enzyme	2.7.11.1 [ Enzyme-Expasy ]   2.7.11.1 [ Enzyme-SRS ]   2.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   2.7.11.1 [ WIT ]
GO	G2/M transition of mitotic cell cycle [Amigo]  G2/M transition of mitotic cell cycle
GO	nucleotide binding [Amigo]  nucleotide binding
GO	magnesium ion binding [Amigo]  magnesium ion binding
GO	sister chromatid segregation [Amigo]  sister chromatid segregation
GO	spindle pole [Amigo]  spindle pole
GO	protein serine/threonine kinase activity [Amigo]  protein serine/threonine kinase activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	centrosome [Amigo]  centrosome
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	mitosis [Amigo]  mitosis
GO	hormone-mediated signaling [Amigo]  hormone-mediated signaling
GO	transferase activity [Amigo]  transferase activity
GO	protein kinase binding [Amigo]  protein kinase binding
GO	regulation of actin filament polymerization [Amigo]  regulation of actin filament polymerization
GO	negative regulation of cyclin-dependent protein kinase activity [Amigo]  negative regulation of cyclin-dependent protein kinase activity
GO	cell division [Amigo]  cell division
PubGene	LATS1
TreeFam	LATS1
CTD	9113 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	LATS1 Related clones (RZPD - Berlin)
	PubMed
PubMed	21 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:17:49 2008