LIG1 (DNA ligase 1)

2003-11-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 3978
MIM: 126391
HGNC: 6598
Ensembl: ENSG00000105486

Variants:

dbSNP: 3978
ClinVar: 3978
TCGA: ENSG00000105486
COSMIC: LIG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105486ENST00000263274P18858
ENSG00000105486ENST00000427526P18858
ENSG00000105486ENST00000536218F5GZ28
ENSG00000105486ENST00000542460B4E135
ENSG00000105486ENST00000593425M0QY71
ENSG00000105486ENST00000594759M0R0Q7
ENSG00000105486ENST00000596549M0R1G7
ENSG00000105486ENST00000596672M0R254
ENSG00000105486ENST00000598938M0R1S4
ENSG00000105486ENST00000601091P18858
ENSG00000105486ENST00000613670P18858

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
DNA replicationKEGGko03030
Base excision repairKEGGko03410
Nucleotide excision repairKEGGko03420
Mismatch repairKEGGko03430
DNA replicationKEGGhsa03030
Base excision repairKEGGhsa03410
Nucleotide excision repairKEGGhsa03420
Mismatch repairKEGGhsa03430
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Early Phase of HIV Life CycleREACTOMER-HSA-162594
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
DNA strand elongationREACTOMER-HSA-69190
Lagging Strand SynthesisREACTOMER-HSA-69186
Processive synthesis on the lagging strandREACTOMER-HSA-69183
Chromosome MaintenanceREACTOMER-HSA-73886
Telomere MaintenanceREACTOMER-HSA-157579
Extension of TelomeresREACTOMER-HSA-180786
Telomere C-strand (Lagging Strand) SynthesisREACTOMER-HSA-174417
Processive synthesis on the C-strand of the telomereREACTOMER-HSA-174414
DNA ReplicationREACTOMER-HSA-69306
DNA RepairREACTOMER-HSA-73894
Base Excision RepairREACTOMER-HSA-73884
Resolution of Abasic Sites (AP sites)REACTOMER-HSA-73933
Resolution of AP sites via the multiple-nucleotide patch replacement pathwayREACTOMER-HSA-110373
POLB-Dependent Long Patch Base Excision RepairREACTOMER-HSA-110362
PCNA-Dependent Long Patch Base Excision RepairREACTOMER-HSA-5651801
Mismatch RepairREACTOMER-HSA-5358508
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)REACTOMER-HSA-5358565
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)REACTOMER-HSA-5358606
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
Gap-filling DNA repair synthesis and ligation in GG-NERREACTOMER-HSA-5696397
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
155651462004Human DNA ligase I completely encircles and partially unwinds nicked DNA.140
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
191163882009A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.63
184409842008Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks.56
191244992009Association and interactions between DNA repair gene polymorphisms and adult glioma.52
191244992009Association and interactions between DNA repair gene polymorphisms and adult glioma.52
201503662010DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma.46
172033052007Genetic variation in the base excision repair pathway and bladder cancer risk.43
158716982005The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery.37
171081462006DNA repair and cell cycle control genes and the risk of young-onset lung cancer.36

Citation

Dessen P

LIG1 (DNA ligase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41154/lig1