LIMK2 (LIM domain kinase 2)

2003-11-01  

Identity

HGNC
LOCATION
22q12.2
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 3985
MIM: 601988
HGNC: 6614
Ensembl: ENSG00000182541

Variants:

dbSNP: 3985
ClinVar: 3985
TCGA: ENSG00000182541
COSMIC: LIMK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182541ENST00000331728P53671
ENSG00000182541ENST00000331728A0A024R1H6
ENSG00000182541ENST00000333611P53671
ENSG00000182541ENST00000333611A0A024R1M2
ENSG00000182541ENST00000340552P53671
ENSG00000182541ENST00000406516B5MC51
ENSG00000182541ENST00000425203C9JK61

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Regulation of actin cytoskeletonKEGGko04810
Axon guidanceKEGGhsa04360
Regulation of actin cytoskeletonKEGGhsa04810
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ROCKsREACTOMER-HSA-5627117
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Sema4D in semaphorin signalingREACTOMER-HSA-400685
Sema4D induced cell migration and growth-cone collapseREACTOMER-HSA-416572
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
172942302007LIM kinases: function, regulation and association with human disease.102
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
156472842005LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-beta.58
280690002017Long non-coding RNA TUG1 is involved in cell growth and chemoresistance of small cell lung cancer by regulating LIMK2b via EZH2.58
258498652015Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking.53
259811712015Altered expression of CDC42 signaling pathway components in cortical layer 3 pyramidal cells in schizophrenia.37
200474702009LIMK1 and LIMK2 are important for metastatic behavior and tumor cell-induced angiogenesis of pancreatic cancer cells.32
210796532011p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival.30
224929862012LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy.26
271169352016LIMK Regulates Tumor-Cell Invasion and Matrix Degradation Through Tyrosine Phosphorylation of MT1-MMP.21

Citation

Dessen P

LIMK2 (LIM domain kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41160/limk2