MAP2K2 (mitogen-activated protein kinase kinase 2)

2003-11-01 Affiliation

Identity

HGNC

MAP2K2

LOCATION

19p13.3

LOCUSID

5605

ALIAS

CFC4,MAPKK2,MEK2,MKK2,PRKMK2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5605
MIM: 601263
HGNC: 6842
Ensembl: ENSG00000126934

Variants:

dbSNP: 5605
ClinVar: 5605
TCGA: ENSG00000126934
COSMIC: MAP2K2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000126934	ENST00000262948	P36507
ENSG00000126934	ENST00000394867	G5E9C7
ENSG00000126934	ENST00000599021	M0R1B6

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
ErbB signaling pathway	KEGG	ko04012
Autophagy - animal	KEGG	ko04140
mTOR signaling pathway	KEGG	ko04150
Apoptosis	KEGG	ko04210
VEGF signaling pathway	KEGG	ko04370
Gap junction	KEGG	ko04540
Toll-like receptor signaling pathway	KEGG	ko04620
Natural killer cell mediated cytotoxicity	KEGG	ko04650
T cell receptor signaling pathway	KEGG	ko04660
B cell receptor signaling pathway	KEGG	ko04662
Fc epsilon RI signaling pathway	KEGG	ko04664
Long-term potentiation	KEGG	ko04720
Long-term depression	KEGG	ko04730
Regulation of actin cytoskeleton	KEGG	ko04810
Insulin signaling pathway	KEGG	ko04910
GnRH signaling pathway	KEGG	ko04912
Melanogenesis	KEGG	ko04916
Renal cell carcinoma	KEGG	ko05211
Endometrial cancer	KEGG	ko05213
Glioma	KEGG	ko05214
Prostate cancer	KEGG	ko05215
Thyroid cancer	KEGG	ko05216
Melanoma	KEGG	ko05218
Bladder cancer	KEGG	ko05219
Chronic myeloid leukemia	KEGG	ko05220
Acute myeloid leukemia	KEGG	ko05221
Non-small cell lung cancer	KEGG	ko05223
MAPK signaling pathway	KEGG	hsa04010
ErbB signaling pathway	KEGG	hsa04012
Autophagy - animal	KEGG	hsa04140
mTOR signaling pathway	KEGG	hsa04150
Apoptosis	KEGG	hsa04210
VEGF signaling pathway	KEGG	hsa04370
Gap junction	KEGG	hsa04540
Toll-like receptor signaling pathway	KEGG	hsa04620
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
T cell receptor signaling pathway	KEGG	hsa04660
B cell receptor signaling pathway	KEGG	hsa04662
Fc epsilon RI signaling pathway	KEGG	hsa04664
Long-term potentiation	KEGG	hsa04720
Long-term depression	KEGG	hsa04730
Regulation of actin cytoskeleton	KEGG	hsa04810
Insulin signaling pathway	KEGG	hsa04910
GnRH signaling pathway	KEGG	hsa04912
Melanogenesis	KEGG	hsa04916
Pathways in cancer	KEGG	hsa05200
Renal cell carcinoma	KEGG	hsa05211
Endometrial cancer	KEGG	hsa05213
Glioma	KEGG	hsa05214
Prostate cancer	KEGG	hsa05215
Thyroid cancer	KEGG	hsa05216
Melanoma	KEGG	hsa05218
Bladder cancer	KEGG	hsa05219
Chronic myeloid leukemia	KEGG	hsa05220
Acute myeloid leukemia	KEGG	hsa05221
Non-small cell lung cancer	KEGG	hsa05223
Vascular smooth muscle contraction	KEGG	hsa04270
Vascular smooth muscle contraction	KEGG	ko04270
Neurotrophin signaling pathway	KEGG	ko04722
Prion diseases	KEGG	ko05020
Neurotrophin signaling pathway	KEGG	hsa04722
Prion diseases	KEGG	hsa05020
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Hepatitis B	KEGG	hsa05161
HIF-1 signaling pathway	KEGG	hsa04066
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Estrogen signaling pathway	KEGG	hsa04915
Estrogen signaling pathway	KEGG	ko04915
Prolactin signaling pathway	KEGG	hsa04917
Prolactin signaling pathway	KEGG	ko04917
MicroRNAs in cancer	KEGG	hsa05206
MicroRNAs in cancer	KEGG	ko05206
Ras signaling pathway	KEGG	hsa04014
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
FoxO signaling pathway	KEGG	hsa04068
Thyroid hormone signaling pathway	KEGG	hsa04919
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Signaling pathways regulating pluripotency of stem cells	KEGG	hsa04550
Signaling pathways regulating pluripotency of stem cells	KEGG	ko04550
Central carbon metabolism in cancer	KEGG	hsa05230
Choline metabolism in cancer	KEGG	hsa05231
Central carbon metabolism in cancer	KEGG	ko05230
Choline metabolism in cancer	KEGG	ko05231
MAPK (ERK1/2) signaling	KEGG	hsa_M00687
MAPK (ERK1/2) signaling	KEGG	M00687
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Infectious disease	REACTOME	R-HSA-5663205
Uptake and actions of bacterial toxins	REACTOME	R-HSA-5339562
Uptake and function of anthrax toxins	REACTOME	R-HSA-5210891
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
RAF activation	REACTOME	R-HSA-5673000
MAP2K and MAPK activation	REACTOME	R-HSA-5674135
Negative regulation of MAPK pathway	REACTOME	R-HSA-5675221
Negative feedback regulation of MAPK pathway	REACTOME	R-HSA-5674499
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
RAF-independent MAPK1/3 activation	REACTOME	R-HSA-112409
MAPK1 (ERK2) activation	REACTOME	R-HSA-112411
Signaling by GPCR	REACTOME	R-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
L1CAM interactions	REACTOME	R-HSA-373760
Signal transduction by L1	REACTOME	R-HSA-445144
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072
EGFR tyrosine kinase inhibitor resistance	KEGG	ko01521
Endocrine resistance	KEGG	ko01522
EGFR tyrosine kinase inhibitor resistance	KEGG	hsa01521
Endocrine resistance	KEGG	hsa01522
RET signaling	REACTOME	R-HSA-8853659
Breast cancer	KEGG	ko05224
Breast cancer	KEGG	hsa05224
Oncogenic MAPK signaling	REACTOME	R-HSA-6802957
Signaling by RAS mutants	REACTOME	R-HSA-6802949
Signaling by high-kinase activity BRAF mutants	REACTOME	R-HSA-6802948
Signaling by moderate kinase activity BRAF mutants	REACTOME	R-HSA-6802946
Paradoxical activation of RAF signaling by kinase inactive BRAF	REACTOME	R-HSA-6802955
Signaling by BRAF and RAF fusions	REACTOME	R-HSA-6802952
Apelin signaling pathway	KEGG	hsa04371

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA24928	ARAF	Gene	Pathway	associated
PA25408	BRAF	Gene	Pathway	associated	28362716
PA283	MAPK8	Gene	Pathway	associated	20124951
PA30616	MAPK1	Gene	Pathway	associated	20124951, 28362716
PA30617	MAPK10	Gene	Pathway	associated	20124951
PA30618	MAPK11	Gene	Pathway	associated	20124951
PA30619	MAPK12	Gene	Pathway	associated	20124951
PA30620	MAPK13	Gene	Pathway	associated	20124951
PA30621	MAPK14	Gene	Pathway	associated	20124951
PA30622	MAPK3	Gene	Pathway	associated	20124951, 28362716
PA30623	MAPK4	Gene	Pathway	associated	20124951
PA30624	MAPK6	Gene	Pathway	associated	20124951
PA30625	MAPK7	Gene	Pathway	associated	20124951
PA30630	MAPK9	Gene	Pathway	associated	20124951
PA34183	RAF1	Gene	Pathway	associated	20124951, 28362716

References

Pubmed ID	Year	Title	Citations
38259097	2024	Lung Fibroblasts Take up Breast Cancer Cell-derived Extracellular Vesicles Partially Through MEK2-dependent Macropinocytosis.	1
38259097	2024	Lung Fibroblasts Take up Breast Cancer Cell-derived Extracellular Vesicles Partially Through MEK2-dependent Macropinocytosis.	1
35075244	2022	YTHDF2 promotes multiple myeloma cell proliferation via STAT5A/MAP2K2/p-ERK axis.	20
35157553	2022	MAP2K2 Delays Recovery in Murine Models of Acute Lung Injury and Associates with Acute Respiratory Distress Syndrome Outcome.	1
35075244	2022	YTHDF2 promotes multiple myeloma cell proliferation via STAT5A/MAP2K2/p-ERK axis.	20
35157553	2022	MAP2K2 Delays Recovery in Murine Models of Acute Lung Injury and Associates with Acute Respiratory Distress Syndrome Outcome.	1
33226073	2021	O-GlcNAcylation of MEK2 promotes the proliferation and migration of breast cancer cells.	4
33839686	2021	MEK1/2 activity modulates TREM2 cell surface recruitment.	3
34026451	2021	Dual Inhibition of DKC1 and MEK1/2 Synergistically Restrains the Growth of Colorectal Cancer Cells.	24
34715128	2021	The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation.	14
35069558	2021	The Predictive Value of MAP2K1/2 Mutations on Efficiency of Immunotherapy in Melanoma.	7
33226073	2021	O-GlcNAcylation of MEK2 promotes the proliferation and migration of breast cancer cells.	4
33839686	2021	MEK1/2 activity modulates TREM2 cell surface recruitment.	3
34026451	2021	Dual Inhibition of DKC1 and MEK1/2 Synergistically Restrains the Growth of Colorectal Cancer Cells.	24
34715128	2021	The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation.	14

Citation

Dessen P

MAP2K2 (mitogen-activated protein kinase kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41271/map2k2

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