MAP3K3 (mitogen-activated protein kinase kinase kinase 3)

2003-11-01  

Identity

HGNC
MAP3K3
LOCATION
17q23.3
LOCUSID
4215
ALIAS
MAPKKK3,MEKK3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4215
MIM: 602539
HGNC: 6855
Ensembl: ENSG00000198909

Variants:

dbSNP: 4215
ClinVar: 4215
TCGA: ENSG00000198909
COSMIC: MAP3K3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198909ENST00000361357Q99759
ENSG00000198909ENST00000361733Q99759
ENSG00000198909ENST00000577395J3KRN4
ENSG00000198909ENST00000577597J3KTC4
ENSG00000198909ENST00000579585Q99759
ENSG00000198909ENST00000581732J3QS19
ENSG00000198909ENST00000584573J3QRB6
ENSG00000198909ENST00000585302J3QS54

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
GnRH signaling pathwayKEGGko04912
MAPK signaling pathwayKEGGhsa04010
GnRH signaling pathwayKEGGhsa04912
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
MAPK (JNK) signalingKEGGhsa_M00688
MAPK (p38) signalingKEGGhsa_M00689
MAPK (ERK5) signalingKEGGhsa_M00690
MAPK (JNK) signalingKEGGM00688
MAPK (p38) signalingKEGGM00689
MAPK (ERK5) signalingKEGGM00690
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-1 signalingREACTOMER-HSA-446652

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
270272842016Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.62
199038152010PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation.41
150015762004TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis.39
167379602006TLR8-mediated NF-kappaB and JNK activation are TAK1-independent and MEKK3-dependent.37
162607832005TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation.36
206157642010The epidermal growth factor receptor modulates DNA double-strand break repair by regulating non-homologous end-joining.35
221055802012Exogenous and autocrine growth factors stimulate human intervertebral disc cell proliferation via the ERK and Akt pathways.21
155726792004Restoration of NF-kappaB activation by tumor necrosis factor alpha receptor complex-targeted MEKK3 in receptor-interacting protein-deficient cells.18
164073012006Phosphorylation of serine 526 is required for MEKK3 activity, and association with 14-3-3 blocks dephosphorylation.18

Citation

Dessen P

MAP3K3 (mitogen-activated protein kinase kinase kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41280/map3k3