MAPK1 (mitogen-activated protein kinase 1)

Identity

Other names	ERK
	ERK2
	ERT1
	MAPK2
	P42MAPK
	PRKM1
	PRKM2
	p38
	p40
	p41
	p41mapk
HGNC	MAPK1
Location	22q11.2
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	MAPK1   6871
Entrez_Gene	MAPK1  5594  mitogen-activated protein kinase 1
	Cards
GeneCards	MAPK1
Ensembl	MAPK1 [Search_View]   ENSG00000100030 [Gene_View]
Genatlas	MAPK1
GeneLynx	MAPK1
eGenome	MAPK1
euGene	5594
	Genomic and cartography
GoldenPath	MAPK1  -  22q11.2   chr22:20443947-20551970 -  22q11.21   [Description]    (hg18-March_2006)
Ensembl	MAPK1 - 22q11.21 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	MAPK1
	Gene and transcription
Genbank	AI004470 [ ENTREZ ]
Genbank	AK055080 [ ENTREZ ]
Genbank	AK057143 [ ENTREZ ]
Genbank	AK090869 [ ENTREZ ]
Genbank	AK307615 [ ENTREZ ]
RefSeq	NM_002745 [ SRS ]    NM_002745 [ ENTREZ ]
RefSeq	NM_138957 [ SRS ]    NM_138957 [ ENTREZ ]
RefSeq	AC_000065 [ SRS ]    AC_000065 [ ENTREZ ]
RefSeq	AC_000154 [ SRS ]    AC_000154 [ ENTREZ ]
RefSeq	NC_000022 [ SRS ]    NC_000022 [ ENTREZ ]
RefSeq	NT_011520 [ SRS ]    NT_011520 [ ENTREZ ]
RefSeq	NW_001838745 [ SRS ]    NW_001838745 [ ENTREZ ]
RefSeq	NW_927628 [ SRS ]    NW_927628 [ ENTREZ ]
AceView	MAPK1 AceView - NCBI
Unigene	Hs.431850 [ SRS ]    Hs.431850 [ NCBI ]     HS431850 [ spliceNest ]
Fast-db	2154 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P28482 [ SRS]    P28482 [ EXPASY ]     P28482 [ INTERPRO ]     P28482 [ UNIPROT ]
Prosite	PS01351 MAPK [ SRS ]    PS01351 MAPK [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Interpro	IPR008349 Erk_1_2_MAPK [ SRS ]    IPR008349 Erk_1_2_MAPK [ EBI ]
Interpro	IPR003527 MAP_kin_CS [ SRS ]    IPR003527 MAP_kin_CS [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR002290 Ser_thr_pkinase [ SRS ]    IPR002290 Ser_thr_pkinase [ EBI ]
CluSTr	P28482
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Smart	SM00220 S_TKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	P28482 MK01_HUMAN [ Domain structure ]   P28482 MK01_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P28482
PDB	1PME [ SRS ]    1PME [ PdbSum ],   1PME [ IMB ]   1PME [ RSDB ]
PDB	1TVO [ SRS ]    1TVO [ PdbSum ],   1TVO [ IMB ]   1TVO [ RSDB ]
PDB	1WZY [ SRS ]    1WZY [ PdbSum ],   1WZY [ IMB ]   1WZY [ RSDB ]
PDB	2E14 [ SRS ]    2E14 [ PdbSum ],   2E14 [ IMB ]   2E14 [ RSDB ]
PDB	2OJG [ SRS ]    2OJG [ PdbSum ],   2OJG [ IMB ]   2OJG [ RSDB ]
PDB	2OJI [ SRS ]    2OJI [ PdbSum ],   2OJI [ IMB ]   2OJI [ RSDB ]
PDB	2OJJ [ SRS ]    2OJJ [ PdbSum ],   2OJJ [ IMB ]   2OJJ [ RSDB ]
HPRD	01496
	Protein Interaction databases
DIP	P28482
IntAct	P28482
	Polymorphism : SNP, mutations, diseases
OMIM	176948    [ map ]
GENECLINICS	176948
SNP	MAPK1 [dbSNP-NCBI]
SNP	NM_002745 [SNP-NCI]
SNP	NM_138957 [SNP-NCI]
SNP	MAPK1 [GeneSNPs - Utah]  MAPK1] [HGBASE - SRS]
HAPMAP	MAPK1 [HAPMAP]
COSMIC	MAPK1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	MAPK1
	General knowledge
Family Browser	MAPK1 [UCSC Family Browser]
SOURCE	NM_002745
SOURCE	NM_138957
SMD	Hs.431850
SAGE	Hs.431850
Enzyme	2.7.11.24 [ Enzyme-Expasy ]   2.7.11.24 [ Enzyme-SRS ]   2.7.11.24 [ IntEnz-EBI ]   2.7.11.24 [ BRENDA ]   2.7.11.24 [ KEGG ]   2.7.11.24 [ WIT ]
GO	MAPKKK cascade [Amigo]  MAPKKK cascade
GO	nucleotide binding [Amigo]  nucleotide binding
GO	phosphotyrosine binding [Amigo]  phosphotyrosine binding
GO	protein serine/threonine kinase activity [Amigo]  protein serine/threonine kinase activity
GO	protein serine/threonine kinase activity [Amigo]  protein serine/threonine kinase activity
GO	MAP kinase activity [Amigo]  MAP kinase activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	nucleus [Amigo]  nucleus
GO	nucleoplasm [Amigo]  nucleoplasm
GO	cytoplasm [Amigo]  cytoplasm
GO	cytosol [Amigo]  cytosol
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	induction of apoptosis [Amigo]  induction of apoptosis
GO	chemotaxis [Amigo]  chemotaxis
GO	response to DNA damage stimulus [Amigo]  response to DNA damage stimulus
GO	cell cycle [Amigo]  cell cycle
GO	Ras protein signal transduction [Amigo]  Ras protein signal transduction
GO	synaptic transmission [Amigo]  synaptic transmission
GO	organ morphogenesis [Amigo]  organ morphogenesis
GO	transferase activity [Amigo]  transferase activity
GO	cytosine metabolic process [Amigo]  cytosine metabolic process
GO	lipopolysaccharide-mediated signaling pathway [Amigo]  lipopolysaccharide-mediated signaling pathway
GO	response to lipopolysaccharide [Amigo]  response to lipopolysaccharide
GO	response to exogenous dsRNA [Amigo]  response to exogenous dsRNA
GO	interspecies interaction between organisms [Amigo]  interspecies interaction between organisms
GO	negative regulation of cell differentiation [Amigo]  negative regulation of cell differentiation
BIOCARTA	Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling    [Genes]
BIOCARTA	CCR3 signaling in Eosinophils    [Genes]
BIOCARTA	Influence of Ras and Rho proteins on G1 to S Transition    [Genes]
BIOCARTA	Agrin in Postsynaptic Differentiation    [Genes]
BIOCARTA	Oxidative Stress Induced Gene Expression Via Nrf2    [Genes]
BIOCARTA	Roles of ß-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling    [Genes]
BIOCARTA	Regulation of BAD phosphorylation    [Genes]
BIOCARTA	Role of ß-arrestins in the activation and targeting of MAP kinases    [Genes]
BIOCARTA	Bioactive Peptide Induced Signaling Pathway    [Genes]
BIOCARTA	Cadmium induces DNA synthesis and proliferation in macrophages    [Genes]
BIOCARTA	Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway    [Genes]
BIOCARTA	Ceramide Signaling Pathway    [Genes]
BIOCARTA	Transcription factor CREB and its extracellular signals    [Genes]
BIOCARTA	CXCR4 Signaling Pathway    [Genes]
BIOCARTA	Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia    [Genes]
BIOCARTA	Phospholipids as signalling intermediaries    [Genes]
BIOCARTA	Regulation of eIF4e and p70 S6 Kinase    [Genes]
BIOCARTA	Role of Erk5 in Neuronal Survival    [Genes]
BIOCARTA	Erk1/Erk2 Mapk Signaling pathway    [Genes]
BIOCARTA	fMLP induced chemokine gene expression in HMC-1 cells    [Genes]
BIOCARTA	Fc Epsilon Receptor I Signaling in Mast Cells    [Genes]
BIOCARTA	Human Cytomegalovirus and Map Kinase Pathways    [Genes]
BIOCARTA	Role of ERBB2 in Signal Transduction and Oncology    [Genes]
BIOCARTA	Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation    [Genes]
BIOCARTA	Integrin Signaling Pathway    [Genes]
BIOCARTA	Keratinocyte Differentiation    [Genes]
BIOCARTA	Role of MAL in Rho-Mediated Activation of SRF    [Genes]
BIOCARTA	MAPKinase Signaling Pathway    [Genes]
BIOCARTA	Signaling of Hepatocyte Growth Factor Receptor    [Genes]
BIOCARTA	NFAT and Hypertrophy of the heart (Transcription in the broken heart)    [Genes]
BIOCARTA	Pelp1 Modulation of Estrogen Receptor Activity    [Genes]
BIOCARTA	PTEN dependent cell cycle arrest and apoptosis    [Genes]
BIOCARTA	Links between Pyk2 and Map Kinases    [Genes]
BIOCARTA	Regulation of Splicing through Sam68    [Genes]
BIOCARTA	Aspirin Blocks Signaling Pathway Involved in Platelet Activation    [Genes]
BIOCARTA	Sprouty regulation of tyrosine kinase signals    [Genes]
BIOCARTA	Trefoil Factors Initiate Mucosal Healing    [Genes]
KEGG	MAPK signaling pathway
KEGG	mTOR signaling pathway
KEGG	Dorso-ventral axis formation
KEGG	TGF-beta signaling pathway
KEGG	Axon guidance
KEGG	VEGF signaling pathway
KEGG	Focal adhesion
KEGG	Adherens junction
KEGG	Gap junction
KEGG	Natural killer cell mediated cytotoxicity
KEGG	Fc epsilon RI signaling pathway
KEGG	Long-term potentiation
KEGG	Long-term depression
KEGG	Regulation of actin cytoskeleton
KEGG	Insulin signaling pathway
KEGG	GnRH signaling pathway
KEGG	Type II diabetes mellitus
KEGG	Colorectal cancer
PubGene	MAPK1
TreeFam	MAPK1
CTD	5594 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	MAPK1 Related clones (RZPD - Berlin)
	PubMed
PubMed	499 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:19:21 2008