MAPKAP1 (MAPK associated protein 1)

2007-12-01 Affiliation

Identity

HGNC

MAPKAP1

LOCATION

9q33.3

LOCUSID

79109

ALIAS

JC310,MIP1,SIN1,SIN1b,SIN1g

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 79109
MIM: 610558
HGNC: 18752
Ensembl: ENSG00000119487

Variants:

dbSNP: 79109
ClinVar: 79109
TCGA: ENSG00000119487
COSMIC: MAPKAP1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000119487	ENST00000265960	Q9BPZ7
ENSG00000119487	ENST00000350766	Q9BPZ7
ENSG00000119487	ENST00000350766	A0A024R863
ENSG00000119487	ENST00000373496	B1AMB2
ENSG00000119487	ENST00000373498	Q9BPZ7
ENSG00000119487	ENST00000373503	Q9BPZ7
ENSG00000119487	ENST00000373511	Q9BPZ7
ENSG00000119487	ENST00000394060	Q9BPZ7
ENSG00000119487	ENST00000394063	Q9BPZ7
ENSG00000119487	ENST00000420643	B1AMA5
ENSG00000119487	ENST00000427078	B1AMA6
ENSG00000119487	ENST00000433483	B1AMB1
ENSG00000119487	ENST00000444226	H0Y7F8
ENSG00000119487	ENST00000468896	H0Y866
ENSG00000119487	ENST00000497932	E9PGB8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
mTOR signaling pathway	KEGG	ko04150
mTOR signaling pathway	KEGG	hsa04150
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
PI3K/AKT Signaling in Cancer	REACTOME	R-HSA-2219528
Constitutive Signaling by AKT1 E17K in Cancer	REACTOME	R-HSA-5674400
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Costimulation by the CD28 family	REACTOME	R-HSA-388841
CD28 co-stimulation	REACTOME	R-HSA-389356
CD28 dependent PI3K/Akt signaling	REACTOME	R-HSA-389357
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
PIP3 activates AKT signaling	REACTOME	R-HSA-1257604
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME	R-HSA-2730905
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GAB1 signalosome	REACTOME	R-HSA-180292
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
PI3K/AKT activation	REACTOME	R-HSA-198203
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated vascular permeability	REACTOME	R-HSA-5218920
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
Regulation of TP53 Activity	REACTOME	R-HSA-5633007
Regulation of TP53 Expression and Degradation	REACTOME	R-HSA-6806003
Regulation of TP53 Degradation	REACTOME	R-HSA-6804757

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
16962653	2006	SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.	591
16919458	2006	mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.	268
17043309	2006	Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.	213
24161930	2013	Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.	98
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
26235620	2015	A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation.	75
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
28143890	2017	Localization of mTORC2 activity inside cells.	51
17303383	2007	Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling.	40
24395886	2014	Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells.	24

Citation

Dessen P

MAPKAP1 (MAPK associated protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49954/mapkap1