MCF2 (MCF.2 cell line derived transforming sequence)

2003-02-01  

Identity

HGNC
LOCATION
Xq27.1
LOCUSID
ALIAS
ARHGEF21,DBL
FUSION GENES

Other Information

Locus ID:

NCBI: 4168
MIM: 311030
HGNC: 6940
Ensembl: ENSG00000101977

Variants:

dbSNP: 4168
ClinVar: 4168
TCGA: ENSG00000101977
COSMIC: MCF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101977ENST00000338585P10911
ENSG00000101977ENST00000370573P10911
ENSG00000101977ENST00000370576P10911
ENSG00000101977ENST00000414978P10911
ENSG00000101977ENST00000437564H0Y662
ENSG00000101977ENST00000446225Q5JYJ5
ENSG00000101977ENST00000519895P10911
ENSG00000101977ENST00000520602A0A2U3TZL4
ENSG00000101977ENST00000536274P10911

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482

References

Pubmed IDYearTitleCitations
204797602011Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia.100
176066142007Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain.59
175380242007Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42.44
187284022008The suppressor of metastasis Nm23-H1 interacts with the Cdc42 Rho family member and the pleckstrin homology domain of oncoprotein Dbl-1 to suppress cell migration.15
229845902012Phosphoinositide 3-kinase C2β regulates RhoA and the actin cytoskeleton through an interaction with Dbl.6
217123852011The tumor suppressor hamartin enhances Dbl protein transforming activity through interaction with ezrin.4
124458222002Alternative splicing variants of the human DBL (MCF-2) proto-oncogene.3
136790592003Characterization of novel splicing variants of the mouse MCF-2 (DBL) proto-oncogene.3
314168442019Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma.3
193734752009Mutational analysis of proto-oncogene Dbl on Xq27 in testicular germ cell tumors reveals a rare SNP in a patient with bilateral undescended testis.2

Citation

Dessen P

MCF2 (MCF.2 cell line derived transforming sequence)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41315/mcf2