MCL1 (MCL1 apoptosis regulator, BCL2 family member)

2003-02-01  

Identity

HGNC
LOCATION
1q21.2
LOCUSID
ALIAS
BCL2L3,EAT,MCL1-ES,MCL1L,MCL1S,Mcl-1,TM,bcl2-L-3,mcl1/EAT
FUSION GENES

Other Information

Locus ID:

NCBI: 4170
MIM: 159552
HGNC: 6943
Ensembl: ENSG00000143384

Variants:

dbSNP: 4170
ClinVar: 4170
TCGA: ENSG00000143384
COSMIC: MCL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143384ENST00000307940Q07820
ENSG00000143384ENST00000369026Q07820
ENSG00000143384ENST00000620947A0A087WT64

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
Jak-STAT signaling pathwayKEGGko04630
ApoptosisKEGGhsa04210
Jak-STAT signaling pathwayKEGGhsa04630
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
159016722005Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.472
165431452006Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1.350
159899572005Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis.332
200236292010Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.275
213688332011SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.265
127838552003Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation.240
150771162004Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.232
173871462007Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization.180
201975522010Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1.154
205262822010Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest.143

Citation

Dessen P

MCL1 (MCL1 apoptosis regulator, BCL2 family member)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41317/mcl1