MLL4 (myeloid/lymphoid or mixed-lineage leukemia 4)

Identity

Other names	HRX2
	KIAA0304
	MLL2
	TRX2
	WBP7
HGNC	-
Location	19q13.1
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	-   -
Entrez_Gene	MLL4  9757  myeloid/lymphoid or mixed-lineage leukemia 4
	Cards
GeneCards	MLL4
Ensembl	MLL4 [Search_View]   ENSG00000105663 [Gene_View]
Genatlas	MLL4
GeneLynx	MLL4
eGenome	MLL4
euGene	9757
	Genomic and cartography
GoldenPath	MLL4  -  19q13.1   chr19:40900761-40921619 +  19q13.12   [Description]    (hg18-March_2006)
Ensembl	MLL4 - 19q13.12 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	MLL4
	Gene and transcription
Genbank	AB002302 [ ENTREZ ]
Genbank	AF104918 [ ENTREZ ]
Genbank	AF105279 [ ENTREZ ]
Genbank	AF105280 [ ENTREZ ]
Genbank	AF186605 [ ENTREZ ]
RefSeq	NM_014727 [ SRS ]    NM_014727 [ ENTREZ ]
RefSeq	AC_000062 [ SRS ]    AC_000062 [ ENTREZ ]
RefSeq	AC_000151 [ SRS ]    AC_000151 [ ENTREZ ]
RefSeq	NC_000019 [ SRS ]    NC_000019 [ ENTREZ ]
RefSeq	NT_011109 [ SRS ]    NT_011109 [ ENTREZ ]
RefSeq	NW_001838494 [ SRS ]    NW_001838494 [ ENTREZ ]
RefSeq	NW_927206 [ SRS ]    NW_927206 [ ENTREZ ]
AceView	MLL4 AceView - NCBI
Unigene	Hs.676457 [ SRS ]    Hs.676457 [ NCBI ]     HS676457 [ spliceNest ]
Fast-db	10947 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q9UMN6 [ SRS]    Q9UMN6 [ EXPASY ]     Q9UMN6 [ INTERPRO ]     Q9UMN6 [ UNIPROT ]
Prosite	PS50868 POST_SET [ SRS ]    PS50868 POST_SET [ Expasy ]
Prosite	PS50280 SET [ SRS ]    PS50280 SET [ Expasy ]
Prosite	PS51058 ZF_CXXC [ SRS ]    PS51058 ZF_CXXC [ Expasy ]
Prosite	PS01359 ZF_PHD_1 [ SRS ]    PS01359 ZF_PHD_1 [ Expasy ]
Prosite	PS50016 ZF_PHD_2 [ SRS ]    PS50016 ZF_PHD_2 [ Expasy ]
Interpro	IPR000637 AT_hook_DNA_bd [ SRS ]    IPR000637 AT_hook_DNA_bd [ EBI ]
Interpro	IPR003889 FYrich_C [ SRS ]    IPR003889 FYrich_C [ EBI ]
Interpro	IPR003888 FYrich_N [ SRS ]    IPR003888 FYrich_N [ EBI ]
Interpro	IPR016569 MeTrfase_trithorax [ SRS ]    IPR016569 MeTrfase_trithorax [ EBI ]
Interpro	IPR015722 MLL [ SRS ]    IPR015722 MLL [ EBI ]
Interpro	IPR003616 Post-SET_Zn_bd [ SRS ]    IPR003616 Post-SET_Zn_bd [ EBI ]
Interpro	IPR001214 SET [ SRS ]    IPR001214 SET [ EBI ]
Interpro	IPR002857 Znf_CXXC [ SRS ]    IPR002857 Znf_CXXC [ EBI ]
Interpro	IPR001965 Znf_PHD [ SRS ]    IPR001965 Znf_PHD [ EBI ]
Interpro	IPR013083 Znf_RING/FYVE/PHD [ SRS ]    IPR013083 Znf_RING/FYVE/PHD [ EBI ]
CluSTr	Q9UMN6
Pfam	PF02178 AT_hook [ SRS ]    PF02178 AT_hook [ Sanger ]    pfam02178 [ NCBI-CDD ]
Pfam	PF05965 FYRC [ SRS ]    PF05965 FYRC [ Sanger ]    pfam05965 [ NCBI-CDD ]
Pfam	PF05964 FYRN [ SRS ]    PF05964 FYRN [ Sanger ]    pfam05964 [ NCBI-CDD ]
Pfam	PF00628 PHD [ SRS ]    PF00628 PHD [ Sanger ]    pfam00628 [ NCBI-CDD ]
Pfam	PF00856 SET [ SRS ]    PF00856 SET [ Sanger ]    pfam00856 [ NCBI-CDD ]
Pfam	PF02008 zf-CXXC [ SRS ]    PF02008 zf-CXXC [ Sanger ]    pfam02008 [ NCBI-CDD ]
Smart	SM00384 AT_hook [EMBL]
Smart	SM00542 FYRC [EMBL]
Smart	SM00541 FYRN [EMBL]
Smart	SM00249 PHD [EMBL]
Smart	SM00508 PostSET [EMBL]
Smart	SM00317 SET [EMBL]
Blocks	Q9UMN6
HPRD	06017
	Protein Interaction databases
DIP	Q9UMN6
IntAct	Q9UMN6
	Polymorphism : SNP, mutations, diseases
OMIM	606834    [ map ]
GENECLINICS	606834
SNP	MLL4 [dbSNP-NCBI]
SNP	NM_014727 [SNP-NCI]
SNP	MLL4 [GeneSNPs - Utah]  MLL4] [HGBASE - SRS]
HAPMAP	MLL4 [HAPMAP]
HGMD	-
	General knowledge
Family Browser	MLL4 [UCSC Family Browser]
SOURCE	NM_014727
SMD	Hs.676457
SAGE	Hs.676457
Enzyme	2.1.1.43 [ Enzyme-Expasy ]   2.1.1.43 [ Enzyme-SRS ]   2.1.1.43 [ IntEnz-EBI ]   2.1.1.43 [ BRENDA ]   2.1.1.43 [ KEGG ]   2.1.1.43 [ WIT ]
GO	transcription factor activity [Amigo]  transcription factor activity
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	transcription [Amigo]  transcription
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	methyltransferase activity [Amigo]  methyltransferase activity
GO	zinc ion binding [Amigo]  zinc ion binding
GO	chromatin modification [Amigo]  chromatin modification
GO	transferase activity [Amigo]  transferase activity
GO	histone-lysine N-methyltransferase activity [Amigo]  histone-lysine N-methyltransferase activity
GO	metal ion binding [Amigo]  metal ion binding
GO	chromatin-mediated maintenance of transcription [Amigo]  chromatin-mediated maintenance of transcription
PubGene	MLL4
TreeFam	-
CTD	9757 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	- Related clones (RZPD - Berlin)
	PubMed
PubMed	11 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:20:27 2008