MMP14 (matrix metallopeptidase 14 (membrane-inserted))

Identity

Other names	MMP-X1
	MT1-MMP
	MTMMP1
HGNC	MMP14
Location	14q11-q12
Location_base_pair	Starts at 22375633 and ends at 22386643 bp from pter (hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	MMP14   7160
Entrez_Gene	MMP14  4323  matrix metallopeptidase 14 (membrane-inserted)
	Cards
GeneCards	MMP14
Ensembl	MMP14 [Search_View]   ENSG00000157227 [Gene_View]
Genatlas	MMP14
GeneLynx	MMP14
eGenome	MMP14
euGene	4323
	Genomic and cartography
GoldenPath	MMP14  -     chr14:22375633-22386643 +  14q11.2   [Description]    (hg18-March_2006)
Ensembl	MMP14 - 14q11.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	MMP14
	Gene and transcription
Genbank	AK291325 [ ENTREZ ]
Genbank	AK312657 [ ENTREZ ]
Genbank	BC039581 [ ENTREZ ]
Genbank	BC064803 [ ENTREZ ]
Genbank	D26512 [ ENTREZ ]
RefSeq	NM_004995 [ SRS ]    NM_004995 [ ENTREZ ]
RefSeq	AC_000057 [ SRS ]    AC_000057 [ ENTREZ ]
RefSeq	AC_000146 [ SRS ]    AC_000146 [ ENTREZ ]
RefSeq	NC_000014 [ SRS ]    NC_000014 [ ENTREZ ]
RefSeq	NT_026437 [ SRS ]    NT_026437 [ ENTREZ ]
RefSeq	NW_001838110 [ SRS ]    NW_001838110 [ ENTREZ ]
RefSeq	NW_925539 [ SRS ]    NW_925539 [ ENTREZ ]
AceView	MMP14 AceView - NCBI
Unigene	Hs.2399 [ SRS ]    Hs.2399 [ NCBI ]     HS2399 [ spliceNest ]
Fast-db	57 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P50281 [ SRS]    P50281 [ EXPASY ]     P50281 [ INTERPRO ]     P50281 [ UNIPROT ]
Prosite	PS00546 CYSTEINE_SWITCH [ SRS ]    PS00546 CYSTEINE_SWITCH [ Expasy ]
Prosite	PS00024 HEMOPEXIN [ SRS ]    PS00024 HEMOPEXIN [ Expasy ]
Prosite	PS00142 ZINC_PROTEASE [ SRS ]    PS00142 ZINC_PROTEASE [ Expasy ]
Interpro	IPR000585 Hemopexin [ SRS ]    IPR000585 Hemopexin [ EBI ]
Interpro	IPR001818 Pept_M10A_M12B [ SRS ]    IPR001818 Pept_M10A_M12B [ EBI ]
Interpro	IPR016293 Pept_M10A_matrix [ SRS ]    IPR016293 Pept_M10A_matrix [ EBI ]
Interpro	IPR006025 Pept_M_Zn_BS [ SRS ]    IPR006025 Pept_M_Zn_BS [ EBI ]
Interpro	IPR006026 Peptidase_M [ SRS ]    IPR006026 Peptidase_M [ EBI ]
Interpro	IPR002477 Peptidoglycan-bd-like [ SRS ]    IPR002477 Peptidoglycan-bd-like [ EBI ]
CluSTr	P50281
Pfam	PF00045 Hemopexin [ SRS ]    PF00045 Hemopexin [ Sanger ]    pfam00045 [ NCBI-CDD ]
Pfam	PF00413 Peptidase_M10 [ SRS ]    PF00413 Peptidase_M10 [ Sanger ]    pfam00413 [ NCBI-CDD ]
Pfam	PF01471 PG_binding_1 [ SRS ]    PF01471 PG_binding_1 [ Sanger ]    pfam01471 [ NCBI-CDD ]
Smart	SM00120 HX [EMBL]
Smart	SM00235 ZnMc [EMBL]
Blocks	P50281
PDB	1BQQ [ SRS ]    1BQQ [ PdbSum ],   1BQQ [ IMB ]   1BQQ [ RSDB ]
PDB	1BUV [ SRS ]    1BUV [ PdbSum ],   1BUV [ IMB ]   1BUV [ RSDB ]
HPRD	02856
	Protein Interaction databases
DIP	P50281
IntAct	P50281
	Polymorphism : SNP, mutations, diseases
OMIM	600754    [ map ]
GENECLINICS	600754
SNP	MMP14 [dbSNP-NCBI]
SNP	NM_004995 [SNP-NCI]
SNP	MMP14 [GeneSNPs - Utah]  MMP14] [HGBASE - SRS]
HAPMAP	MMP14 [HAPMAP]
COSMIC	MMP14 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	MMP14
	General knowledge
Family Browser	MMP14 [UCSC Family Browser]
SOURCE	NM_004995
SMD	Hs.2399
SAGE	Hs.2399
Enzyme	3.4.24.80 [ Enzyme-Expasy ]   3.4.24.80 [ Enzyme-SRS ]   3.4.24.80 [ IntEnz-EBI ]   3.4.24.80 [ BRENDA ]   3.4.24.80 [ KEGG ]   3.4.24.80 [ WIT ]
GO	ossification [Amigo]  ossification
GO	angiogenesis [Amigo]  angiogenesis
GO	ovarian follicle development [Amigo]  ovarian follicle development
GO	response to hypoxia [Amigo]  response to hypoxia
GO	endothelial cell proliferation [Amigo]  endothelial cell proliferation
GO	metalloendopeptidase activity [Amigo]  metalloendopeptidase activity
GO	calcium ion binding [Amigo]  calcium ion binding
GO	protein binding [Amigo]  protein binding
GO	proteinaceous extracellular matrix [Amigo]  proteinaceous extracellular matrix
GO	cytoplasm [Amigo]  cytoplasm
GO	integral to plasma membrane [Amigo]  integral to plasma membrane
GO	proteolysis [Amigo]  proteolysis
GO	response to oxidative stress [Amigo]  response to oxidative stress
GO	metabolic process [Amigo]  metabolic process
GO	zinc ion binding [Amigo]  zinc ion binding
GO	response to mechanical stimulus [Amigo]  response to mechanical stimulus
GO	response to hormone stimulus [Amigo]  response to hormone stimulus
GO	membrane [Amigo]  membrane
GO	cell migration [Amigo]  cell migration
GO	protease activator activity [Amigo]  protease activator activity
GO	lung development [Amigo]  lung development
GO	zymogen activation [Amigo]  zymogen activation
GO	melanosome [Amigo]  melanosome
GO	astrocyte cell migration [Amigo]  astrocyte cell migration
GO	response to estrogen stimulus [Amigo]  response to estrogen stimulus
GO	branching morphogenesis of a tube [Amigo]  branching morphogenesis of a tube
GO	tissue remodeling [Amigo]  tissue remodeling
GO	negative regulation of focal adhesion formation [Amigo]  negative regulation of focal adhesion formation
BIOCARTA	Inhibition of Matrix Metalloproteinases    [Genes]
KEGG	GnRH signaling pathway
PubGene	MMP14
TreeFam	MMP14
CTD	4323 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	MMP14 Related clones (RZPD - Berlin)
	PubMed
PubMed	159 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 11 13:21:53 2008