NAA10 (N-alpha-acetyltransferase 10, NatA catalytic subunit)

2010-02-01  

Identity

HGNC
LOCATION
Xq28
LOCUSID
ALIAS
ARD1,ARD1A,ARD1P,DXS707,MCOPS1,NATD,OGDNS,TE2,hARD1
FUSION GENES

Other Information

Locus ID:

NCBI: 8260
MIM: 300013
HGNC: 18704
Ensembl: ENSG00000102030

Variants:

dbSNP: 8260
ClinVar: 8260
TCGA: ENSG00000102030
COSMIC: NAA10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102030ENST00000370009P41227
ENSG00000102030ENST00000370011C9JN83
ENSG00000102030ENST00000370015F8W808
ENSG00000102030ENST00000393712A8MWP7
ENSG00000102030ENST00000432089C9JW55
ENSG00000102030ENST00000464845P41227

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124641822002Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation.183
217002662011Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency.99
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
154961422005Identification and characterization of the human ARD1-NATH protein acetyltransferase complex.66
154961422005Identification and characterization of the human ARD1-NATH protein acetyltransferase complex.66
154961422005Identification and characterization of the human ARD1-NATH protein acetyltransferase complex.66
213832062011Proteome-derived peptide libraries allow detailed analysis of the substrate specificities of N(alpha)-acetyltransferases and point to hNaa10p as the post-translational actin N(alpha)-acetyltransferase.56
165184072006Induction of apoptosis in human cells by RNAi-mediated knockdown of hARD1 and NATH, components of the protein N-alpha-acetyltransferase complex.43
201541452010The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation.43
162887482005Interaction between HIF-1 alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1 alpha.42

Citation

Dessen P

NAA10 (N-alpha-acetyltransferase 10, NatA catalytic subunit)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51322/naa10