NCOA2 (nuclear receptor coactivator 2)

Identity

Other names	GRIP1
	KAT13C
	MGC138808
	NCoA-2
	TIF2
HGNC	NCOA2
Location	8q13.3
Location_base_pair	Starts at 71186821 and ends at 71478574 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	NCOA2   7669
Entrez_Gene	NCOA2  10499  nuclear receptor coactivator 2
	Cards
GeneCards	NCOA2
Ensembl	NCOA2 [Search_View]   ENSG00000142453 [Gene_View]
Genatlas	NCOA2
GeneLynx	NCOA2
eGenome	NCOA2
euGene	10499
	Genomic and cartography
GoldenPath	NCOA2  -  8q13.3   chr8:71186821-71478574 -  8q13.3   [Description]    (hg18-March_2006)
Ensembl	NCOA2 - 8q13.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	NCOA2
	Gene and transcription
Genbank	AK308426 [ ENTREZ ]
Genbank	AW504723 [ ENTREZ ]
Genbank	BC092442 [ ENTREZ ]
Genbank	BC114383 [ ENTREZ ]
Genbank	CK141607 [ ENTREZ ]
RefSeq	NM_006540 [ SRS ]    NM_006540 [ ENTREZ ]
RefSeq	AC_000051 [ SRS ]    AC_000051 [ ENTREZ ]
RefSeq	AC_000140 [ SRS ]    AC_000140 [ ENTREZ ]
RefSeq	NC_000008 [ SRS ]    NC_000008 [ ENTREZ ]
RefSeq	NT_008183 [ SRS ]    NT_008183 [ ENTREZ ]
RefSeq	NW_001839132 [ SRS ]    NW_001839132 [ ENTREZ ]
RefSeq	NW_923929 [ SRS ]    NW_923929 [ ENTREZ ]
AceView	NCOA2 AceView - NCBI
Unigene	Hs.446678 [ SRS ]    Hs.446678 [ NCBI ]     HS446678 [ spliceNest ]
Fast-db	5964 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q14CD2 [ SRS]    Q14CD2 [ EXPASY ]     Q14CD2 [ INTERPRO ]     Q14CD2 [ UNIPROT ]
Prosite	PS00018 EF_HAND_1 [ SRS ]    PS00018 EF_HAND_1 [ Expasy ]
Prosite	PS50888 HLH [ SRS ]    PS50888 HLH [ Expasy ]
Prosite	PS50112 PAS [ SRS ]    PS50112 PAS [ Expasy ]
Interpro	IPR010011 DUF1518 [ SRS ]    IPR010011 DUF1518 [ EBI ]
Interpro	IPR002048 EF_hand_Ca_bd [ SRS ]    IPR002048 EF_hand_Ca_bd [ EBI ]
Interpro	IPR001092 HLH_basic [ SRS ]    IPR001092 HLH_basic [ EBI ]
Interpro	IPR014920 Nuc_rcpt_coact_Ncoa-typ [ SRS ]    IPR014920 Nuc_rcpt_coact_Ncoa-typ [ EBI ]
Interpro	IPR017426 Nuclear_rcpt_coactivator [ SRS ]    IPR017426 Nuclear_rcpt_coactivator [ EBI ]
Interpro	IPR001610 PAC [ SRS ]    IPR001610 PAC [ EBI ]
Interpro	IPR000014 PAS [ SRS ]    IPR000014 PAS [ EBI ]
Interpro	IPR013767 PAS_fold [ SRS ]    IPR013767 PAS_fold [ EBI ]
Interpro	IPR014935 SRC-1 [ SRS ]    IPR014935 SRC-1 [ EBI ]
CluSTr	Q14CD2
Pfam	PF07469 DUF1518 [ SRS ]    PF07469 DUF1518 [ Sanger ]    pfam07469 [ NCBI-CDD ]
Pfam	PF08815 Nuc_rec_co-act [ SRS ]    PF08815 Nuc_rec_co-act [ Sanger ]    pfam08815 [ NCBI-CDD ]
Pfam	PF00989 PAS [ SRS ]    PF00989 PAS [ Sanger ]    pfam00989 [ NCBI-CDD ]
Pfam	PF08832 SRC-1 [ SRS ]    PF08832 SRC-1 [ Sanger ]    pfam08832 [ NCBI-CDD ]
Smart	SM00353 HLH [EMBL]
Smart	SM00086 PAC [EMBL]
Smart	SM00091 PAS [EMBL]
Blocks	Q14CD2
HPRD	09066
	Protein Interaction databases
DIP	Q14CD2
IntAct	Q14CD2
	Polymorphism : SNP, mutations, diseases
OMIM	601993    [ map ]
GENECLINICS	601993
SNP	NCOA2 [dbSNP-NCBI]
SNP	NM_006540 [SNP-NCI]
SNP	NCOA2 [GeneSNPs - Utah]  NCOA2] [HGBASE - SRS]
HAPMAP	NCOA2 [HAPMAP]
COSMIC	NCOA2 [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	negative [Translocation breakpoints In Cancer]
HGMD	NCOA2
	General knowledge
Family Browser	NCOA2 [UCSC Family Browser]
SOURCE	NM_006540
SMD	Hs.446678
SAGE	Hs.446678
GO	negative regulation of transcription from RNA polymerase II promoter [Amigo]  negative regulation of transcription from RNA polymerase II promoter
GO	transcription coactivator activity [Amigo]  transcription coactivator activity
GO	signal transducer activity [Amigo]  signal transducer activity
GO	receptor binding [Amigo]  receptor binding
GO	nucleus [Amigo]  nucleus
GO	cytoplasm [Amigo]  cytoplasm
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	signal transduction [Amigo]  signal transduction
GO	transcription repressor activity [Amigo]  transcription repressor activity
GO	thyroid hormone receptor coactivator activity [Amigo]  thyroid hormone receptor coactivator activity
GO	steroid hormone receptor signaling pathway [Amigo]  steroid hormone receptor signaling pathway
GO	nuclear hormone receptor binding [Amigo]  nuclear hormone receptor binding
GO	positive regulation of transcription from RNA polymerase II promoter [Amigo]  positive regulation of transcription from RNA polymerase II promoter
BIOCARTA	Role of PPAR-gamma Coactivators in Obesity and Thermogenesis    [Genes]
BIOCARTA	Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells    [Genes]
BIOCARTA	Control of Gene Expression by Vitamin D Receptor    [Genes]
PubGene	NCOA2
TreeFam	NCOA2
CTD	10499 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	NCOA2 Related clones (RZPD - Berlin)
	PubMed
PubMed	76 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Tue Oct 14 20:44:16 2008