NEK2 (NIMA related kinase 2)

2006-10-01  

Identity

HGNC
LOCATION
1q32.3
LOCUSID
ALIAS
HsPK21,NEK2A,NLK1,PPP1R111,RP67
FUSION GENES

Other Information

Locus ID:

NCBI: 4751
MIM: 604043
HGNC: 7745
Ensembl: ENSG00000117650

Variants:

dbSNP: 4751
ClinVar: 4751
TCGA: ENSG00000117650
COSMIC: NEK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117650ENST00000366998P51955
ENSG00000117650ENST00000366999P51955
ENSG00000117650ENST00000540251F6U4U2

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
Regulation of mitotic cell cycleREACTOMER-HSA-453276
APC/C-mediated degradation of cell cycle proteinsREACTOMER-HSA-174143
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsREACTOMER-HSA-176814
APC/C:Cdc20 mediated degradation of mitotic proteinsREACTOMER-HSA-176409
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointREACTOMER-HSA-179419
APC-Cdc20 mediated degradation of Nek2AREACTOMER-HSA-179409
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
180868582008beta-Catenin is a Nek2 substrate involved in centrosome separation.93
128578712003Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles.90
210764102010Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction.78
154922582004The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer.68
160840112006Nek2 kinase in chromosome instability and cancer.58
262904192015Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle.52
171976992007Structure and regulation of the human Nek2 centrosomal kinase.46
190380012009Nek2 as a novel molecular target for the treatment of breast carcinoma.46
217231282011Plk1 controls the Nek2A-PP1γ antagonism in centrosome disjunction.45
149780402004NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling.43

Citation

Dessen P

NEK2 (NIMA related kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43372/nek2