NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha)

Identity

Other names	IKBA
	MAD-3
	NFKBI
HGNC	NFKBIA
Location	14q13
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	NFKBIA   7797
Entrez_Gene	NFKBIA  4792  nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
	Cards
GeneCards	NFKBIA
Ensembl	NFKBIA [Search_View]   ENSG00000100906 [Gene_View]
Genatlas	NFKBIA
GeneLynx	NFKBIA
eGenome	NFKBIA
euGene	4792
	Genomic and cartography
GoldenPath	NFKBIA  -  14q13   chr14:34940467-34943711 -  14q13.2   [Description]    (hg18-March_2006)
Ensembl	NFKBIA - 14q13.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	NFKBIA
	Gene and transcription
Genbank	AK311515 [ ENTREZ ]
Genbank	AK313421 [ ENTREZ ]
Genbank	AY033600 [ ENTREZ ]
Genbank	BC002601 [ ENTREZ ]
Genbank	BC004983 [ ENTREZ ]
RefSeq	NM_020529 [ SRS ]    NM_020529 [ ENTREZ ]
RefSeq	AC_000057 [ SRS ]    AC_000057 [ ENTREZ ]
RefSeq	AC_000146 [ SRS ]    AC_000146 [ ENTREZ ]
RefSeq	NC_000014 [ SRS ]    NC_000014 [ ENTREZ ]
RefSeq	NG_007571 [ SRS ]    NG_007571 [ ENTREZ ]
RefSeq	NT_026437 [ SRS ]    NT_026437 [ ENTREZ ]
RefSeq	NW_001838110 [ SRS ]    NW_001838110 [ ENTREZ ]
RefSeq	NW_925539 [ SRS ]    NW_925539 [ ENTREZ ]
AceView	NFKBIA AceView - NCBI
Unigene	Hs.81328 [ SRS ]    Hs.81328 [ NCBI ]     HS81328 [ spliceNest ]
Fast-db	150 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P25963 [ SRS]    P25963 [ EXPASY ]     P25963 [ INTERPRO ]     P25963 [ UNIPROT ]
Prosite	PS50297 ANK_REP_REGION [ SRS ]    PS50297 ANK_REP_REGION [ Expasy ]
Prosite	PS50088 ANK_REPEAT [ SRS ]    PS50088 ANK_REPEAT [ Expasy ]
Interpro	IPR002110 ANK [ SRS ]    IPR002110 ANK [ EBI ]
Interpro	IPR015681 NF_kB_inhbitor [ SRS ]    IPR015681 NF_kB_inhbitor [ EBI ]
CluSTr	P25963
Pfam	PF00023 Ank [ SRS ]    PF00023 Ank [ Sanger ]    pfam00023 [ NCBI-CDD ]
Smart	SM00248 ANK [EMBL]
Blocks	P25963
PDB	1IKN [ SRS ]    1IKN [ PdbSum ],   1IKN [ IMB ]   1IKN [ RSDB ]
PDB	1NFI [ SRS ]    1NFI [ PdbSum ],   1NFI [ IMB ]   1NFI [ RSDB ]
HPRD	01235
	Protein Interaction databases
DIP	P25963
IntAct	P25963
	Polymorphism : SNP, mutations, diseases
OMIM	164008;612132    [ map ]
GENECLINICS	164008;612132
SNP	NFKBIA [dbSNP-NCBI]
SNP	NM_020529 [SNP-NCI]
SNP	NFKBIA [GeneSNPs - Utah]  NFKBIA] [HGBASE - SRS]
HAPMAP	NFKBIA [HAPMAP]
COSMIC	NFKBIA [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	NFKBIA
	General knowledge
Family Browser	NFKBIA [UCSC Family Browser]
SOURCE	NM_020529
SMD	Hs.81328
SAGE	Hs.81328
GO	protein import into nucleus, translocation [Amigo]  protein import into nucleus, translocation
GO	nucleus [Amigo]  nucleus
GO	cytoplasm [Amigo]  cytoplasm
GO	cytosol [Amigo]  cytosol
GO	cytosol [Amigo]  cytosol
GO	apoptosis [Amigo]  apoptosis
GO	cytoplasmic sequestering of NF-kappaB [Amigo]  cytoplasmic sequestering of NF-kappaB
GO	nuclear localization sequence binding [Amigo]  nuclear localization sequence binding
GO	ubiquitin protein ligase binding [Amigo]  ubiquitin protein ligase binding
GO	lipopolysaccharide-mediated signaling pathway [Amigo]  lipopolysaccharide-mediated signaling pathway
GO	response to lipopolysaccharide [Amigo]  response to lipopolysaccharide
GO	regulation of cell proliferation [Amigo]  regulation of cell proliferation
GO	regulation of NF-kappaB import into nucleus [Amigo]  regulation of NF-kappaB import into nucleus
GO	identical protein binding [Amigo]  identical protein binding
GO	response to exogenous dsRNA [Amigo]  response to exogenous dsRNA
GO	negative regulation of DNA binding [Amigo]  negative regulation of DNA binding
GO	interspecies interaction between organisms [Amigo]  interspecies interaction between organisms
GO	negative regulation of myeloid cell differentiation [Amigo]  negative regulation of myeloid cell differentiation
GO	negative regulation of Notch signaling pathway [Amigo]  negative regulation of Notch signaling pathway
GO	NF-kappaB binding [Amigo]  NF-kappaB binding
BIOCARTA	The 4-1BB-dependent immune response    [Genes]
BIOCARTA	HIV-I Nef: negative effector of Fas and TNF    [Genes]
BIOCARTA	Acetylation and Deacetylation of RelA in The Nucleus    [Genes]
BIOCARTA	Influence of Ras and Rho proteins on G1 to S Transition    [Genes]
BIOCARTA	AKT Signaling Pathway    [Genes]
BIOCARTA	ATM Signaling Pathway    [Genes]
BIOCARTA	CD40L Signaling Pathway    [Genes]
BIOCARTA	Cadmium induces DNA synthesis and proliferation in macrophages    [Genes]
BIOCARTA	Induction of apoptosis through DR3 and DR4/5 Death Receptors    [Genes]
BIOCARTA	Erythropoietin mediated neuroprotection through NF-kB    [Genes]
BIOCARTA	fMLP induced chemokine gene expression in HMC-1 cells    [Genes]
BIOCARTA	Signal transduction through IL1R    [Genes]
BIOCARTA	Keratinocyte Differentiation    [Genes]
BIOCARTA	MAPKinase Signaling Pathway    [Genes]
BIOCARTA	NF-kB Signaling Pathway    [Genes]
BIOCARTA	NFkB activation by Nontypeable Hemophilus influenzae    [Genes]
BIOCARTA	Activation of PKC through G protein coupled receptor    [Genes]
BIOCARTA	Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)    [Genes]
BIOCARTA	Double Stranded RNA Induced Gene Expression    [Genes]
BIOCARTA	TNF/Stress Related Signaling    [Genes]
BIOCARTA	T Cell Receptor Signaling Pathway    [Genes]
BIOCARTA	Chaperones modulate interferon Signaling Pathway    [Genes]
BIOCARTA	TNFR2 Signaling Pathway    [Genes]
BIOCARTA	Toll-Like Receptor Pathway    [Genes]
BIOCARTA	Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells    [Genes]
KEGG	Apoptosis
KEGG	Toll-like receptor signaling pathway
KEGG	T cell receptor signaling pathway
KEGG	B cell receptor signaling pathway
KEGG	Adipocytokine signaling pathway
KEGG	Epithelial cell signaling in Helicobacter pylori infection
PubGene	NFKBIA
TreeFam	NFKBIA
CTD	4792 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	NFKBIA Related clones (RZPD - Berlin)
	PubMed
PubMed	186 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:22:02 2008