NLK (nemo like kinase)

2006-10-01  

Identity

HGNC
LOCATION
17q11.2
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 51701
MIM: 609476
HGNC: 29858
Ensembl: ENSG00000087095

Variants:

dbSNP: 51701
ClinVar: 51701
TCGA: ENSG00000087095
COSMIC: NLK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000087095ENST00000407008Q9UBE8
ENSG00000087095ENST00000407008A0A024QZ12
ENSG00000087095ENST00000496808H0YD75
ENSG00000087095ENST00000582037J3QSE9

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Wnt signaling pathwayKEGGko04310
Adherens junctionKEGGko04520
MAPK signaling pathwayKEGGhsa04010
Wnt signaling pathwayKEGGhsa04310
Adherens junctionKEGGhsa04520
FoxO signaling pathwayKEGGhsa04068
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124829672003The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling.174
125564972003Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling.83
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
201189212010Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex.43
149605822004Wnt activates the Tak1/Nemo-like kinase pathway.41
279799722017Phosphorylation by NLK inhibits YAP-14-3-3-interactions and induces its nuclear localization.35
157647092005STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation.31
234166992013miR-92b controls glioma proliferation and invasion through regulating Wnt/beta-catenin signaling via Nemo-like kinase.30
187656722008Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation.28
195140492009Nemo-like kinase induces apoptosis and inhibits androgen receptor signaling in prostate cancer cells.25

Citation

Dessen P

NLK (nemo like kinase)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43380/nlk