NOS2 (nitric oxide synthase 2)

2003-06-01  

Identity

HGNC
LOCATION
17q11.2
LOCUSID
ALIAS
HEP-NOS,INOS,NOS,NOS2A
FUSION GENES

Other Information

Locus ID:

NCBI: 4843
MIM: 163730
HGNC: 7873
Ensembl: ENSG00000007171

Variants:

dbSNP: 4843
ClinVar: 4843
TCGA: ENSG00000007171
COSMIC: NOS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000007171ENST00000313735P35228
ENSG00000007171ENST00000621962P35228
ENSG00000007171ENST00000646938A0A2R8YDS4

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
Arginine biosynthesisKEGGko00220
Arginine and proline metabolismKEGGko00330
Calcium signaling pathwayKEGGko04020
Small cell lung cancerKEGGko05222
Arginine biosynthesisKEGGhsa00220
Arginine and proline metabolismKEGGhsa00330
Calcium signaling pathwayKEGGhsa04020
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Metabolic pathwaysKEGGhsa01100
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
PertussisKEGGko05133
PertussisKEGGhsa05133
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
HIF-1 signaling pathwayKEGGhsa04066
ROS, RNS production in phagocytesREACTOMER-HSA-1222556
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Nitric oxide stimulates guanylate cyclaseREACTOMER-HSA-392154
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164925725Toxic liver diseaseDiseaseClinicalAnnotationassociatedPD22341855
PA445941TuberculosisDiseaseClinicalAnnotationassociatedPD22341855
PA449412doxorubicinChemicalPathwayassociated21048526
PA449957ibuprofenChemicalPathwayassociated25502615
PA450112isoniazidChemicalClinicalAnnotationassociatedPD22341855
PA451250rifampinChemicalClinicalAnnotationassociatedPD22341855

References

Pubmed IDYearTitleCitations
204388562010Regulation of the expression of inducible nitric oxide synthase.138
217297802011Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2.117
209531892010Genome-wide association analysis identifies three psoriasis susceptibility loci.106
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
263353992015The dual role of iNOS in cancer.92
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
209783572010Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients.85
163527372005A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis.78
177208132007NOS2 regulation of NF-kappaB by S-nitrosylation of p65.77
162604912005Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase.69

Citation

Dessen P

NOS2 (nitric oxide synthase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41553/nos2