NOTCH4 (notch receptor 4)

2003-02-01  

Identity

HGNC
LOCATION
6p21.32
LOCUSID
ALIAS
INT3
FUSION GENES

Other Information

Locus ID:

NCBI: 4855
MIM: 164951
HGNC: 7884
Ensembl: ENSG00000204301

Variants:

dbSNP: 4855
ClinVar: 4855
TCGA: ENSG00000204301
COSMIC: NOTCH4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204301ENST00000375023Q99466
ENSG00000204301ENST00000375023A0A1U9X983

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Dorso-ventral axis formationKEGGko04320
Notch signaling pathwayKEGGko04330
Notch signaling pathwayKEGGhsa04330
Dorso-ventral axis formationKEGGhsa04320
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Thyroid hormone signaling pathwayKEGGhsa04919
Notch signalingKEGGhsa_M00682
Notch signalingKEGGM00682
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Transcription and TranslationREACTOMER-HSA-1912408
Pre-NOTCH Processing in the Endoplasmic ReticulumREACTOMER-HSA-1912399
Pre-NOTCH Processing in GolgiREACTOMER-HSA-1912420
Signaling by NOTCH4REACTOMER-HSA-1980150
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Notch-HLH transcription pathwayREACTOMER-HSA-350054
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective LFNG causes SCDO3REACTOMER-HSA-5083630
Endocrine resistanceKEGGko01522
Endocrine resistanceKEGGhsa01522
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166120929severe cutaneous adverse reactionsDiseaseClinicalAnnotationassociatedPD29193002
PA448320allopurinolChemicalClinicalAnnotationassociatedPD29193002

References

Pubmed IDYearTitleCitations
185839792008Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.395
200681612010Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.203
185939232008Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches.131
208320562011Genome-wide association study of schizophrenia in a Japanese population.75
234442122013Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma.72
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51
263879462015Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.50
211596512010Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype.48
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
119099752002Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation.45

Citation

Dessen P

NOTCH4 (notch receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41558/notch4