NTRK1 (neurotrophic tyrosine kinase, receptor, type 1)

Identity

Other names	DKFZp781I14186
	MTC
	TRK
	TRK1
	TRKA
	p140-TrkA
HGNC	NTRK1
Location	1q21-q22
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

Breakpoints

External links

	Nomenclature
HGNC	NTRK1   8031
Entrez_Gene	NTRK1  4914  neurotrophic tyrosine kinase, receptor, type 1
	Cards
GeneCards	NTRK1
Ensembl	NTRK1 [Search_View]   ENSG00000198400 [Gene_View]
Genatlas	NTRK1
GeneLynx	NTRK1
eGenome	NTRK1
euGene	4914
	Genomic and cartography
GoldenPath	NTRK1  -     chr1:155052166-155118266 +  1q23.1   [Description]    (hg18-March_2006)
Ensembl	NTRK1 - 1q23.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	NTRK1
	Gene and transcription
Genbank	AK126428 [ ENTREZ ]
Genbank	AK290759 [ ENTREZ ]
Genbank	AK312704 [ ENTREZ ]
Genbank	BC062580 [ ENTREZ ]
Genbank	BM685020 [ ENTREZ ]
RefSeq	NM_001007792 [ SRS ]    NM_001007792 [ ENTREZ ]
RefSeq	NM_001012331 [ SRS ]    NM_001012331 [ ENTREZ ]
RefSeq	NM_002529 [ SRS ]    NM_002529 [ ENTREZ ]
RefSeq	AC_000044 [ SRS ]    AC_000044 [ ENTREZ ]
RefSeq	AC_000133 [ SRS ]    AC_000133 [ ENTREZ ]
RefSeq	NC_000001 [ SRS ]    NC_000001 [ ENTREZ ]
RefSeq	NG_007493 [ SRS ]    NG_007493 [ ENTREZ ]
RefSeq	NT_004487 [ SRS ]    NT_004487 [ ENTREZ ]
RefSeq	NW_001838531 [ SRS ]    NW_001838531 [ ENTREZ ]
RefSeq	NW_925683 [ SRS ]    NW_925683 [ ENTREZ ]
AceView	NTRK1 AceView - NCBI
Unigene	Hs.406293 [ SRS ]    Hs.406293 [ NCBI ]     HS406293 [ spliceNest ]
Fast-db	17417 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P04629 [ SRS]    P04629 [ EXPASY ]     P04629 [ INTERPRO ]     P04629 [ UNIPROT ]
Prosite	PS50835 IG_LIKE [ SRS ]    PS50835 IG_LIKE [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00109 PROTEIN_KINASE_TYR [ SRS ]    PS00109 PROTEIN_KINASE_TYR [ Expasy ]
Prosite	PS00239 RECEPTOR_TYR_KIN_II [ SRS ]    PS00239 RECEPTOR_TYR_KIN_II [ Expasy ]
Interpro	IPR007110 Ig-like [ SRS ]    IPR007110 Ig-like [ EBI ]
Interpro	IPR013783 Ig-like_fold [ SRS ]    IPR013783 Ig-like_fold [ EBI ]
Interpro	IPR003599 Ig_sub [ SRS ]    IPR003599 Ig_sub [ EBI ]
Interpro	IPR001611 LRR [ SRS ]    IPR001611 LRR [ EBI ]
Interpro	IPR000483 LRR_C [ SRS ]    IPR000483 LRR_C [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR002011 Recept_tyr_kinase-II_CS [ SRS ]    IPR002011 Recept_tyr_kinase-II_CS [ EBI ]
Interpro	IPR001245 Tyr_pkinase [ SRS ]    IPR001245 Tyr_pkinase [ EBI ]
Interpro	IPR008266 Tyr_pkinase_AS [ SRS ]    IPR008266 Tyr_pkinase_AS [ EBI ]
CluSTr	P04629
Pfam	PF00560 LRR_1 [ SRS ]    PF00560 LRR_1 [ Sanger ]    pfam00560 [ NCBI-CDD ]
Pfam	PF07714 Pkinase_Tyr [ SRS ]    PF07714 Pkinase_Tyr [ Sanger ]    pfam07714 [ NCBI-CDD ]
Smart	SM00409 IG [EMBL]
Smart	SM00082 LRRCT [EMBL]
Smart	SM00219 TyrKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	P04629 NTRK1_HUMAN [ Domain structure ]   P04629 NTRK1_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P04629
PDB	1HE7 [ SRS ]    1HE7 [ PdbSum ],   1HE7 [ IMB ]   1HE7 [ RSDB ]
PDB	1SHC [ SRS ]    1SHC [ PdbSum ],   1SHC [ IMB ]   1SHC [ RSDB ]
PDB	1WWA [ SRS ]    1WWA [ PdbSum ],   1WWA [ IMB ]   1WWA [ RSDB ]
PDB	1WWW [ SRS ]    1WWW [ PdbSum ],   1WWW [ IMB ]   1WWW [ RSDB ]
PDB	2IFG [ SRS ]    2IFG [ PdbSum ],   2IFG [ IMB ]   2IFG [ RSDB ]
HPRD	01869
	Protein Interaction databases
DIP	P04629
IntAct	P04629
	Polymorphism : SNP, mutations, diseases
OMIM	155240;191315;256800    [ map ]
GENECLINICS	155240;191315;256800
SNP	NTRK1 [dbSNP-NCBI]
SNP	NM_001007792 [SNP-NCI]
SNP	NM_001012331 [SNP-NCI]
SNP	NM_002529 [SNP-NCI]
SNP	NTRK1 [GeneSNPs - Utah]  NTRK1] [HGBASE - SRS]
HAPMAP	NTRK1 [HAPMAP]
COSMIC	NTRK1 [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	nucleotide [Translocation breakpoints In Cancer]
HGMD	NTRK1
	General knowledge
Family Browser	NTRK1 [UCSC Family Browser]
SOURCE	NM_001007792
SOURCE	NM_001012331
SOURCE	NM_002529
SMD	Hs.406293
SAGE	Hs.406293
Enzyme	2.7.10.1 [ Enzyme-Expasy ]   2.7.10.1 [ Enzyme-SRS ]   2.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   2.7.10.1 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	transmembrane receptor protein tyrosine kinase activity [Amigo]  transmembrane receptor protein tyrosine kinase activity
GO	transmembrane receptor protein tyrosine kinase activity [Amigo]  transmembrane receptor protein tyrosine kinase activity
GO	receptor activity [Amigo]  receptor activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	cellular_component [Amigo]  cellular_component
GO	endosome [Amigo]  endosome
GO	plasma membrane [Amigo]  plasma membrane
GO	plasma membrane [Amigo]  plasma membrane
GO	integral to plasma membrane [Amigo]  integral to plasma membrane
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	transmembrane receptor protein tyrosine kinase signaling pathway [Amigo]  transmembrane receptor protein tyrosine kinase signaling pathway
GO	transmembrane receptor protein tyrosine kinase signaling pathway [Amigo]  transmembrane receptor protein tyrosine kinase signaling pathway
GO	activation of adenylate cyclase activity [Amigo]  activation of adenylate cyclase activity
GO	Ras protein signal transduction [Amigo]  Ras protein signal transduction
GO	multicellular organismal development [Amigo]  multicellular organismal development
GO	nervous system development [Amigo]  nervous system development
GO	biological_process [Amigo]  biological_process
GO	integral to membrane [Amigo]  integral to membrane
GO	kinase activity [Amigo]  kinase activity
GO	transferase activity [Amigo]  transferase activity
GO	cell differentiation [Amigo]  cell differentiation
GO	neurotrophin binding [Amigo]  neurotrophin binding
BIOCARTA	Y branching of actin filaments    [Genes]
BIOCARTA	Role of Erk5 in Neuronal Survival    [Genes]
BIOCARTA	Trka Receptor Signaling Pathway    [Genes]
KEGG	MAPK signaling pathway
KEGG	Apoptosis
PubGene	NTRK1
TreeFam	NTRK1
CTD	4914 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	NTRK1 Related clones (RZPD - Berlin)
	PubMed
PubMed	137 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:22:52 2008