OS9 (OS9 endoplasmic reticulum lectin)

2003-02-01 Affiliation

Identity

HGNC

OS9

LOCATION

12q13.3

LOCUSID

10956

ALIAS

ERLEC2,OS-9

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10956
MIM: 609677
HGNC: 16994
Ensembl: ENSG00000135506

Variants:

dbSNP: 10956
ClinVar: 10956
TCGA: ENSG00000135506
COSMIC: OS9

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000135506	ENST00000257966	Q13438
ENSG00000135506	ENST00000315970	Q13438
ENSG00000135506	ENST00000389142	Q13438
ENSG00000135506	ENST00000389146	Q13438
ENSG00000135506	ENST00000413095	B4E321
ENSG00000135506	ENST00000435406	Q13438
ENSG00000135506	ENST00000439210	Q13438
ENSG00000135506	ENST00000547079	F8W1V2
ENSG00000135506	ENST00000550372	F8VZI7
ENSG00000135506	ENST00000550848	F8VWQ2
ENSG00000135506	ENST00000551035	Q13438
ENSG00000135506	ENST00000551285	F8VWQ2
ENSG00000135506	ENST00000552285	Q13438
ENSG00000135506	ENST00000552423	F8W0R2
ENSG00000135506	ENST00000552787	F8W1N0

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
HRD1/SEL1 ERAD complex	KEGG	hsa_M00403
HRD1/SEL1 ERAD complex	KEGG	M00403
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	REACTOME	R-HSA-532668
Calnexin/calreticulin cycle	REACTOME	R-HSA-901042
ER Quality Control Compartment (ERQC)	REACTOME	R-HSA-901032
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Hh mutants abrogate ligand secretion	REACTOME	R-HSA-5387390
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	REACTOME	R-HSA-5362768
Disorders of transmembrane transporters	REACTOME	R-HSA-5619115
ABC transporter disorders	REACTOME	R-HSA-5619084
Defective CFTR causes cystic fibrosis	REACTOME	R-HSA-5678895
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Hedgehog	REACTOME	R-HSA-5358351
Hedgehog ligand biogenesis	REACTOME	R-HSA-5358346
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
ABC-family proteins mediated transport	REACTOME	R-HSA-382556

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
18264092	2008	OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.	229
19346256	2009	Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans.	72
18417469	2008	A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal.	48
21172656	2010	Structural basis for oligosaccharide recognition of misfolded glycoproteins by OS-9 in ER-associated degradation.	40
23097496	2012	Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate.	39
25314054	2014	A novel long non-coding RNA ENST00000480739 suppresses tumour cell invasion by regulating OS-9 and HIF-1α in pancreatic ductal adenocarcinoma.	39
20549515	2010	Genome-wide searching of rare genetic variants in WTCCC data.	29
19084021	2009	Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteins.	23
19914915	2010	The sugar-binding ability of human OS-9 and its involvement in ER-associated degradation.	23
17932042	2007	OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum.	21

Citation

Dessen P

OS9 (OS9 endoplasmic reticulum lectin)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41614/os9