PDGFRA (platelet-derived growth factor receptor, alpha polypeptide)

Identity

Other names	CD140A
	MGC74795
	PDGFR2
	Rhe-PDGFRA
Hugo	PDGFRA
Location	4q11-q13
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

Breakpoints

External links

	Nomenclature
Hugo	PDGFRA
GDB	PDGFRA
Entrez_Gene	PDGFRA  5156  platelet-derived growth factor receptor, alpha polypeptide
	Cards
GeneCards	PDGFRA
Ensembl	PDGFRA [Search_View]   ENSG00000134853 [Gene_View]
Genatlas	PDGFRA
GeneLynx	PDGFRA
eGenome	PDGFRA
euGene	5156
	Genomic and cartography
GoldenPath	PDGFRA  -     chr4:54790204-54859168 +  4q12   [Description]    (hg18-March_2006)
Ensembl	PDGFRA - 4q12 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	PDGFRA
	Gene and transcription
Genbank	AA599881 [ ENTREZ ]
Genbank	AA625689 [ ENTREZ ]
Genbank	AV689272 [ ENTREZ ]
Genbank	BC015186 [ ENTREZ ]
Genbank	BC063414 [ ENTREZ ]
RefSeq	NM_006206 [ SRS ]    NM_006206 [ ENTREZ ]
RefSeq	AC_000047 [ SRS ]    AC_000047 [ ENTREZ ]
RefSeq	NC_000004 [ SRS ]    NC_000004 [ ENTREZ ]
RefSeq	NT_022853 [ SRS ]    NT_022853 [ ENTREZ ]
RefSeq	NW_922162 [ SRS ]    NW_922162 [ ENTREZ ]
AceView	PDGFRA AceView - NCBI
Unigene	Hs.74615 [ SRS ]    Hs.74615 [ NCBI ]     HS74615 [ spliceNest ]
Fast-db	4387 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P16234 [ SRS]    P16234 [ EXPASY ]     P16234 [ INTERPRO ]
Prosite	PS50835 IG_LIKE [ SRS ]    PS50835 IG_LIKE [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00109 PROTEIN_KINASE_TYR [ SRS ]    PS00109 PROTEIN_KINASE_TYR [ Expasy ]
Prosite	PS00240 RECEPTOR_TYR_KIN_III [ SRS ]    PS00240 RECEPTOR_TYR_KIN_III [ Expasy ]
Interpro	IPR013151 Ig [ SRS ]    IPR013151 Ig [ EBI ]
Interpro	IPR007110 Ig-like [ SRS ]    IPR007110 Ig-like [ EBI ]
Interpro	IPR013783 Ig-like_fold [ SRS ]    IPR013783 Ig-like_fold [ EBI ]
Interpro	IPR013098 Ig_I-set [ SRS ]    IPR013098 Ig_I-set [ EBI ]
Interpro	IPR003599 Ig_sub [ SRS ]    IPR003599 Ig_sub [ EBI ]
Interpro	IPR003598 Ig_sub2 [ SRS ]    IPR003598 Ig_sub2 [ EBI ]
Interpro	IPR015776 PDGFR_alpha [ SRS ]    IPR015776 PDGFR_alpha [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR001824 Recept_tyr_kinase-III_CS [ SRS ]    IPR001824 Recept_tyr_kinase-III_CS [ EBI ]
Interpro	IPR001245 Tyr_pkinase [ SRS ]    IPR001245 Tyr_pkinase [ EBI ]
Interpro	IPR008266 Tyr_pkinase_AS [ SRS ]    IPR008266 Tyr_pkinase_AS [ EBI ]
Interpro	IPR009134 VEGFR_N [ SRS ]    IPR009134 VEGFR_N [ EBI ]
CluSTr	P16234
Pfam	PF07679 I-set [ SRS ]    PF07679 I-set [ Sanger ]    pfam07679 [ NCBI-CDD ]
Pfam	PF00047 ig [ SRS ]    PF00047 ig [ Sanger ]    pfam00047 [ NCBI-CDD ]
Pfam	PF07714 Pkinase_Tyr [ SRS ]    PF07714 Pkinase_Tyr [ Sanger ]    pfam07714 [ NCBI-CDD ]
Smart	SM00409 IG [EMBL]
Smart	SM00408 IGc2 [EMBL]
Smart	SM00219 TyrKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	P16234 PGFRA_HUMAN [ Domain structure ]   P16234 PGFRA_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P16234
PDB	1GQ5 [ SRS ]    1GQ5 [ PdbSum ],   1GQ5 [ IMB ]   1GQ5 [ RSDB ]
HPRD	01429
	Protein Interaction databases
DIP	P16234
IntAct	P16234
	Polymorphism : SNP, mutations, diseases
OMIM	173490;606764;607685    [ map ]
GENECLINICS	173490;606764;607685
SNP	PDGFRA [dbSNP-NCBI]
SNP	NM_006206 [SNP-NCI]
SNP	PDGFRA [GeneSNPs - Utah]  PDGFRA] [HGBASE - SRS]
HAPMAP	PDGFRA [HAPMAP]
COSMIC	PDGFRA [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	nucleotide [Translocation breakpoints In Cancer]
HGMD	PDGFRA
	General knowledge
Family Browser	PDGFRA [UCSC Family Browser]
SOURCE	NM_006206
SMD	Hs.74615
SAGE	Hs.74615
Enzyme	2.7.10.1 [ Enzyme-SRS ]   2.7.10.1 [ Brenda-SRS ]   2.7.10.1 [ KEGG ]   2.7.10.1 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	receptor activity [Amigo]  receptor activity
GO	platelet-derived growth factor alpha-receptor activity [Amigo]  platelet-derived growth factor alpha-receptor activity
GO	vascular endothelial growth factor receptor activity [Amigo]  vascular endothelial growth factor receptor activity
GO	ATP binding [Amigo]  ATP binding
GO	integral to plasma membrane [Amigo]  integral to plasma membrane
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	cell surface receptor linked signal transduction [Amigo]  cell surface receptor linked signal transduction
GO	transmembrane receptor protein tyrosine kinase signaling pathway [Amigo]  transmembrane receptor protein tyrosine kinase signaling pathway
GO	cell proliferation [Amigo]  cell proliferation
GO	organ morphogenesis [Amigo]  organ morphogenesis
GO	membrane [Amigo]  membrane
GO	transferase activity [Amigo]  transferase activity
GO	extracellular matrix organization and biogenesis [Amigo]  extracellular matrix organization and biogenesis
GO	lung development [Amigo]  lung development
GO	male genitalia development [Amigo]  male genitalia development
GO	odontogenesis of dentine-containing teeth [Amigo]  odontogenesis of dentine-containing teeth
GO	platelet-derived growth factor binding [Amigo]  platelet-derived growth factor binding
BIOCARTA	CBL mediated ligand-induced downregulation of EGF receptors    [Genes]
BIOCARTA	Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration    [Genes]
BIOCARTA	Phospholipids as signalling intermediaries    [Genes]
BIOCARTA	Erk1/Erk2 Mapk Signaling pathway    [Genes]
BIOCARTA	PDGF Signaling Pathway    [Genes]
BIOCARTA	Rac 1 cell motility signaling pathway    [Genes]
KEGG	MAPK signaling pathway
KEGG	Calcium signaling pathway
KEGG	Cytokine-cytokine receptor interaction
KEGG	Focal adhesion
KEGG	Gap junction
KEGG	Regulation of actin cytoskeleton
KEGG	Colorectal cancer
PubGene	PDGFRA
TreeFam	PDGFRA
CTD	5156 [Comparative Genomics Database]
	Other databases
	Probes
Probe	PDGFRA Related clones (RZPD - Berlin)
	PubMed
PubMed	105 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu May 22 20:20:51 2008