PDPK1 (3-phosphoinositide dependent protein kinase-1)

Identity

Other names	MGC20087
	MGC35290
	PDK1
	PRO0461
HGNC	PDPK1
Location	16p13.3
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	PDPK1   8816
Entrez_Gene	PDPK1  5170  3-phosphoinositide dependent protein kinase-1
	Cards
GeneCards	PDPK1
Ensembl	PDPK1 [Search_View]   ENSG00000140992 [Gene_View]
Genatlas	PDPK1
GeneLynx	PDPK1
eGenome	PDPK1
euGene	5170
	Genomic and cartography
GoldenPath	PDPK1  -  16p13.3   chr16:2527971-2593190 +  16p13.3   [Description]    (hg18-March_2006)
Ensembl	PDPK1 - 16p13.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	PDPK1
	Gene and transcription
Genbank	AB209835 [ ENTREZ ]
Genbank	AF017995 [ ENTREZ ]
Genbank	AF111845 [ ENTREZ ]
Genbank	AK095507 [ ENTREZ ]
Genbank	AK131060 [ ENTREZ ]
RefSeq	NM_002613 [ SRS ]    NM_002613 [ ENTREZ ]
RefSeq	NM_031268 [ SRS ]    NM_031268 [ ENTREZ ]
RefSeq	AC_000059 [ SRS ]    AC_000059 [ ENTREZ ]
RefSeq	AC_000148 [ SRS ]    AC_000148 [ ENTREZ ]
RefSeq	NC_000016 [ SRS ]    NC_000016 [ ENTREZ ]
RefSeq	NT_037887 [ SRS ]    NT_037887 [ ENTREZ ]
RefSeq	NW_001838339 [ SRS ]    NW_001838339 [ ENTREZ ]
RefSeq	NW_926018 [ SRS ]    NW_926018 [ ENTREZ ]
AceView	PDPK1 AceView - NCBI
Unigene	Hs.459691 [ SRS ]    Hs.459691 [ NCBI ]     HS459691 [ spliceNest ]
Fast-db	2346 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O15530 [ SRS]    O15530 [ EXPASY ]     O15530 [ INTERPRO ]     O15530 [ UNIPROT ]
Prosite	PS50003 PH_DOMAIN [ SRS ]    PS50003 PH_DOMAIN [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Interpro	IPR001849 PH [ SRS ]    IPR001849 PH [ EBI ]
Interpro	IPR011993 PH_type [ SRS ]    IPR011993 PH_type [ EBI ]
Interpro	IPR015746 PK1_3-phosphoinositide [ SRS ]    IPR015746 PK1_3-phosphoinositide [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR002290 Ser_thr_pkinase [ SRS ]    IPR002290 Ser_thr_pkinase [ EBI ]
CluSTr	O15530
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Smart	SM00220 S_TKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	O15530 PDPK1_HUMAN [ Domain structure ]   O15530 PDPK1_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	O15530
PDB	1H1W [ SRS ]    1H1W [ PdbSum ],   1H1W [ IMB ]   1H1W [ RSDB ]
PDB	1OKY [ SRS ]    1OKY [ PdbSum ],   1OKY [ IMB ]   1OKY [ RSDB ]
PDB	1OKZ [ SRS ]    1OKZ [ PdbSum ],   1OKZ [ IMB ]   1OKZ [ RSDB ]
PDB	1UU3 [ SRS ]    1UU3 [ PdbSum ],   1UU3 [ IMB ]   1UU3 [ RSDB ]
PDB	1UU7 [ SRS ]    1UU7 [ PdbSum ],   1UU7 [ IMB ]   1UU7 [ RSDB ]
PDB	1UU8 [ SRS ]    1UU8 [ PdbSum ],   1UU8 [ IMB ]   1UU8 [ RSDB ]
PDB	1UU9 [ SRS ]    1UU9 [ PdbSum ],   1UU9 [ IMB ]   1UU9 [ RSDB ]
PDB	1UVR [ SRS ]    1UVR [ PdbSum ],   1UVR [ IMB ]   1UVR [ RSDB ]
PDB	1W1D [ SRS ]    1W1D [ PdbSum ],   1W1D [ IMB ]   1W1D [ RSDB ]
PDB	1W1G [ SRS ]    1W1G [ PdbSum ],   1W1G [ IMB ]   1W1G [ RSDB ]
PDB	1W1H [ SRS ]    1W1H [ PdbSum ],   1W1H [ IMB ]   1W1H [ RSDB ]
PDB	1Z5M [ SRS ]    1Z5M [ PdbSum ],   1Z5M [ IMB ]   1Z5M [ RSDB ]
PDB	2BIY [ SRS ]    2BIY [ PdbSum ],   2BIY [ IMB ]   2BIY [ RSDB ]
PDB	2PE0 [ SRS ]    2PE0 [ PdbSum ],   2PE0 [ IMB ]   2PE0 [ RSDB ]
PDB	2PE1 [ SRS ]    2PE1 [ PdbSum ],   2PE1 [ IMB ]   2PE1 [ RSDB ]
PDB	2PE2 [ SRS ]    2PE2 [ PdbSum ],   2PE2 [ IMB ]   2PE2 [ RSDB ]
PDB	2VKI [ SRS ]    2VKI [ PdbSum ],   2VKI [ IMB ]   2VKI [ RSDB ]
HPRD	05556
	Protein Interaction databases
DIP	O15530
IntAct	O15530
	Polymorphism : SNP, mutations, diseases
OMIM	605213    [ map ]
GENECLINICS	605213
SNP	PDPK1 [dbSNP-NCBI]
SNP	NM_002613 [SNP-NCI]
SNP	NM_031268 [SNP-NCI]
SNP	PDPK1 [GeneSNPs - Utah]  PDPK1] [HGBASE - SRS]
HAPMAP	PDPK1 [HAPMAP]
COSMIC	PDPK1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	PDPK1
	General knowledge
Family Browser	PDPK1 [UCSC Family Browser]
SOURCE	NM_002613
SOURCE	NM_031268
SMD	Hs.459691
SAGE	Hs.459691
GO	nucleotide binding [Amigo]  nucleotide binding
GO	cysteine-type endopeptidase activity [Amigo]  cysteine-type endopeptidase activity
GO	protein kinase activity [Amigo]  protein kinase activity
GO	protein serine/threonine kinase activity [Amigo]  protein serine/threonine kinase activity
GO	3-phosphoinositide-dependent protein kinase activity [Amigo]  3-phosphoinositide-dependent protein kinase activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	cytoplasm [Amigo]  cytoplasm
GO	cytosol [Amigo]  cytosol
GO	plasma membrane [Amigo]  plasma membrane
GO	plasma membrane [Amigo]  plasma membrane
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	proteolysis [Amigo]  proteolysis
GO	intracellular signaling cascade [Amigo]  intracellular signaling cascade
GO	insulin receptor signaling pathway [Amigo]  insulin receptor signaling pathway
GO	transferase activity [Amigo]  transferase activity
GO	actin cytoskeleton organization and biogenesis [Amigo]  actin cytoskeleton organization and biogenesis
KEGG	PPAR signaling pathway
KEGG	mTOR signaling pathway
KEGG	Focal adhesion
KEGG	Insulin signaling pathway
PubGene	PDPK1
TreeFam	PDPK1
CTD	5170 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	PDPK1 Related clones (RZPD - Berlin)
	PubMed
PubMed	97 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:24:14 2008