PGD (phosphogluconate dehydrogenase)

2012-10-01  

Identity

HGNC
PGD
LOCATION
1p36.22
LOCUSID
5226
ALIAS
6PGD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5226
MIM: 172200
HGNC: 8891
Ensembl: ENSG00000142657

Variants:

dbSNP: 5226
ClinVar: 5226
TCGA: ENSG00000142657
COSMIC: PGD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142657ENST00000270776P52209
ENSG00000142657ENST00000460189K7EPF6
ENSG00000142657ENST00000465632K7EMN2
ENSG00000142657ENST00000477958K7EJT3
ENSG00000142657ENST00000483936K7ELN9
ENSG00000142657ENST00000491493K7EM49

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pentose phosphate pathwayKEGGko00030
Glutathione metabolismKEGGko00480
Pentose phosphate pathwayKEGGhsa00030
Glutathione metabolismKEGGhsa00480
Metabolic pathwaysKEGGhsa01100
Pentose phosphate pathway (Pentose phosphate cycle)KEGGhsa_M00004
Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5PKEGGhsa_M00006
Pentose phosphate pathway (Pentose phosphate cycle)KEGGM00004
Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5PKEGGM00006
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Pentose phosphate pathway (hexose monophosphate shunt)REACTOMER-HSA-71336

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
206760962010Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers.115
206751012010MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders.105
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
2647931820156-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.56
250428032014Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.29
226771722012Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence.22
223604202012Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.18
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
2397348420136-Phosphogluconate dehydrogenase regulates tumor cell migration in vitro by regulating receptor tyrosine kinase c-Met.9
295349642018Inhibiting 6-phosphogluconate dehydrogenase reverses doxorubicin resistance in anaplastic thyroid cancer via inhibiting NADPH-dependent metabolic reprogramming.7

Citation

Dessen P

PGD (phosphogluconate dehydrogenase)

Atlas Genet Cytogenet Oncol Haematol. 2012-10-01

Online version: http://atlasgeneticsoncology.org/gene/52911/pgd